Clinical Studies and Case Reports

On this site you will find clinical studies with cannabis or single cannabinoids in different diseases and case reports on the use of cannabis by patients.
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TitleSerum Endocannabinoid and Mood Changes after Exercise in Major Depressive Disorder.
Author(s)Meyer JD, Crombie KM, Cook DB, Hillard CJ, Koltyn KF.
Journal, Volume, IssueMed Sci Sports Exerc. [Epub ahead of print]
Major outcome(s)Endocannabinoids contribute to the mood improving effects of exercise in patients with major depression

The endocannabinoid (eCB) system is implicated in the pathophysiology of depression and is responsive to acute exercise in healthy adults.

We aimed to describe acute changes in serum eCBs across a prescribed moderate (MOD) and a self-selected/preferred (PREF) intensity exercise session in women with major depressive disorder (MDD) and determine relationships between changes in eCBs and mood states.

Women with MDD (n=17) exercised in separate sessions for 20 min on a cycle ergometer at both MOD or PREF in a within-subjects design. Blood was drawn before and within 10 min after exercise. Serum concentrations of eCBs (anandamide [AEA]; 2-arachidonoylglycerol [2-AG]) and related lipids (palmitoylethanolamine [PEA]; oleoylethanolamine [OEA]; 2-oleoylglycerol [2-OG]) were quantified using stable isotope-dilution, liquid chromatography/mass spectrometry/mass spectrometry. The profile of mood states and state-trait anxiety inventory (state only) were completed prior to, 10 min and 30 min post-exercise.

Significant elevations in AEA (p=0.013) and OEA (p=0.024) occurred for MOD (moderate effect sizes: Cohen's d=0.58 and 0.41, respectively). Significant (p<0.05) moderate negative associations existed between changes in AEA and mood states for MOD at 10 min (depression, confusion, fatigue, total mood disturbance [TMD] & state anxiety) and 30 min post-exercise (confusion, TMD & state anxiety). Significant (p<0.05) moderate negative associations existed between 2-AG and mood states at 10 min (depression & confusion) and 30 min post-exercise (confusion & TMD). Changes in eCBs or related lipids or eCB-mood relationships were not found for PREF.

Given the broad, moderate-strength relationships between improvements in mood states and eCB increases following MOD, it is plausible that the eCB system contributes to the mood-enhancing effects of prescribed acute exercise in MDD. Alternative mechanisms are likely involved in the positive mood state effects of preferred exercise.

Duration (days)
DesignControlled study
Type of publicationMedical journal
Address of author(s)
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