Clinical Studies and Case Reports

On this site you will find clinical studies with cannabis or single cannabinoids in different diseases and case reports on the use of cannabis by patients.
You may search for diseases (indications), authors, medication, study design (controlled study, open trial, case report etc.) and other criteria.

[Back to Overview]  [IACM Homepage]

TitleLoss of exercise- and stress-induced increases in circulating 2-arachidonoylglycerol concentrations in adults with chronic PTSD.
Author(s)Crombie KM, Leitzelar BN, Brellenthin AG, Hillard CJ, Koltyn KF.
Journal, Volume, IssueBiol Psychol. ;145:1-7. [Epub ahead of print]
Major outcome(s)The endocannabinoid system shows a reduced activity in patients with post-traumatic stress disorder
IndicationPosttraumatic stress disorderAbstract
MedicationOther cannabinoids

The endocannabinoid (eCB) system is a modulatory system that is both altered by stress and mediates the effects of acute stress, including contributing to restoration of homeostasis. Earlier studies suggest that circulating eCBs are dysregulated in adults with post-traumatic stress disorder (PTSD); however, it is not known whether circulating eCBs remain responsive to stress. The purpose of this study was to examine eCB and psychological responses to physical (exercise) and psychosocial (Trier Social Stress Test) stressors, using a randomized, counterbalanced procedure in adults with PTSD and healthy controls (N&#8201;=&#8201;20, mean age&#8201;=&#8201;24, SD&#8201;=&#8201;7 yrs). Results from mixed-design, repeated measures ANOVAs revealed significant increases (p&#8201;<&#8201; .05) in N-arachidonoylethanolamine (AEA) and oleoylethanolamide (OEA) following exercise and psychosocial stress in both groups. However, only the control group exhibited a significant increase (p&#8201;<&#8201;.05) in 2-arachidonoylglycerol (2-AG) following exercise and psychosocial stress exposure. These data extend our current understanding of circulating eCB responsiveness in PTSD, and provide preliminary evidence to suggest that the eCB system is hypoactive in PTSD following exposure to physical and psychosocial stressors.

Duration (days)
DesignControlled study
Type of publicationMedical journal
Address of author(s)
Full text

[Back to Overview]  [IACM Homepage]