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|Title||Efficacy of two cannabis-based medicinal extracts for relief of central neuropathic pain from brachial plexus avulsion: results of a randomised controlled trial|
|Author(s)||Berman J, Lee J, Cooper M, Cannon A, Sach J, McKerral S, Taggart M, Symonds C, Fishel K, Birch R|
|Journal, Volume, Issue||Anaesthesia, 2003;58:938|
|Major outcome(s)||Significant pain relief and improvement of sleep|
Avulsion of nerve rootlets from the spinal cord following traction injuries to the brachial plexus frequently produces a highly characteristic pain syndrome. Constant spontaneous crushing and burning pain is felt in the distal part of the anaesthetic limb, frequently accompanied by shooting pain. It is not uncommon for the pain to persist for many years. The consistency of description between subjects coupled with the anatomical precision of the diagnosis provides a remarkable human model of central neuropathic pain. Opioids, anticonvulsants and tricyclic antidepressants are all used in the empirical management of this condition. They are partially effective at best and there is only anecdotal evidence to support their use. Many of our patients have given us spontaneous reports of the efficacy of 'street' cannabis. This has led us to test two cannabis-based whole plant medicinal extracts administered via oromucosal spray to patients with this condition.
Table 1 shows a summary of the results at week two of each of the study periods.
Baseline Placebo THC* THC:CBD*
|Dose(s)||2,5 mg THC per spray, average 9.2 sprays with THC|
|Participants||48 with neuropathic pain from brachial plexus avulsion|
|Type of publication||Medical journal;Meeting abstract|
|Address of author(s)||Department of Pain Management, Royal National Orthopaedic Hospital, Stanmore, Middlesex, UK; GW Pharmaceuticals, Porton Down Science Park, Salisbury, Wilts, UK|