On this site you will find clinical studies with cannabis or single
cannabinoids in different diseases and case reports on the use of cannabis by
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|Title||Brief Report: Cannabidiol-Rich Cannabis in Children with AUTISM Spectrum Disorder and Severe Behavioral Problems-A Retrospective Feasibility Study.|
|Author(s)||Aran A, Cassuto H, Lubotzky A, Wattad N, Hazan E.|
|Journal, Volume, Issue||J Autism Dev Disord. [Epub ahead of print]|
|Major outcome(s)||Cannabis may be helpful in the treatment of children with AUTISM in an open study|
Anecdotal evidence of successful cannabis treatment in AUTISM spectrum disorder (ASD) are accumulating but clinical studies are lacking. This retrospective study assessed tolerability and efficacy of cannabidiol-rich cannabis, in 60 children with ASD and severe behavioral problems (age = 11.8 ± 3.5, range 5.0-17.5; 77% low functioning; 83% boys). Efficacy was assessed using the Caregiver Global Impression of Change scale. Adverse events included sleep disturbances (14%) irritability (9%) and loss of appetite (9%). One girl who used higher tetrahydrocannabinol had a transient serious psychotic event which required treatment with an antipsychotic. Following the cannabis treatment, behavioral outbreaks were much improved or very much improved in 61% of patients. This preliminary study supports feasibility of CBD-based cannabis trials in children with ASD.
|Type of publication||Medical journal|
|Address of author(s)|