Clinical Studies and Case Reports

On this site you will find clinical studies with cannabis or single cannabinoids in different diseases and case reports on the use of cannabis by patients.
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Author(s)Medina SH, Nadarajah V, Jauregui JJ, Smuda MP, Foster M, Meredith SJ, Packer JD, Henn RF 3rd.
Journal, Volume, IssueSend to Int Orthop. [Epub ahead of print]
Major outcome(s)Cannabis use was associated with less pain after orthopaedic surgery

To determine the baseline clinical characteristics of recreational marijuana users undergoing outpatient orthopaedic surgery. We hypothesized that patients who report marijuana use would have worse pain, function, and general health status.

Nine-hundred and thirty-seven patients undergoing outpatient orthopaedic surgery were asked to fill out patient-reported outcome (PRO) tools. These PROs included the Patient-Reported Outcomes Measurement Information Systems (PROMIS) computer adaptive tests and legacy PROs unique to each patients' surgical site.

Forty patients (4.2%) reported marijuana use. Marijuana use was associated with younger age (33 vs. 43 years, p&#8201;<&#8201;0.001), having a history of fewer operations (1.8 vs. 3.2, p&#8201;<&#8201;0.05), single marital status (68 vs. 38%, p&#8201;<&#8201;0.01), and having a history of smoking cigarettes (63 vs. 31%, p&#8201;<&#8201;0.0001). Marijuana use was found to be significantly associated with greater Marx lower extremity activity rating scale scores (8.5 points vs. 6.1 points, p&#8201;<&#8201;0.05) and decreased pain intensity in the operative site (3.7 points vs. 5.0 points, p&#8201;<&#8201;0.05). Multivariable analysis found that marijuana use was an independent factor associated with less pain intensity in the operative site (p&#8201;<&#8201;0.05).

Our studies support other national studies that report increased marijuana use among younger patients and those who smoke cigarettes. The results do not support our hypothesis, as marijuana use was associated with less pain and better lower extremity activity rating scale scores when compared to non-users. Further research is warranted to analyze the effects of marijuana use on orthopaedic surgery patients.

Duration (days)
DesignOpen study
Type of publicationMedical journal
Address of author(s)
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