Clinical Studies and Case Reports

On this site you will find clinical studies with cannabis or single cannabinoids in different diseases and case reports on the use of cannabis by patients.
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TitleUse of cannabis among 139 cluster headache sufferers.
Author(s)Leroux E, Taifas I, Valade D, Donnet A, Chagnon M, Ducros A.
Journal, Volume, IssueCephalalgia 2013;33(3):208-13.
Major outcome(s)Less than one third of self-reported users mention a relief of their attacks following inhalation.

AIMS: A case report suggested the efficacy of cannabis to treat cluster headache (CH) attacks. Our aims were to study the frequency of cannabis use in CH patients, and the reported effects on attacks.
METHODS: A total of 139 patients with CH attending two French headache centers filled out questionnaires.
RESULTS: Sixty-three of the 139 patients (45.3%) had a history of cannabis use. As compared to nonusers, cannabis users were more likely to be younger (p < 0.001), male (p = 0.002) and tobacco smokers (p < 0.001). Among the 27 patients (19.4% of the total cohort) who had tried cannabis to treat CH attacks, 25.9% reported some efficacy, 51.8% variable or uncertain effects, and 22.3% negative effects.
CONCLUSIONS: Cannabis use is very frequent in CH patients, but its efficacy for the treatment of the attacks is limited. Less than one third of self-reported users mention a relief of their attacks following inhalation. Cannabis should not be recommended for CH unless controlled trials with synthetic selective cannabinoids show a more convincing therapeutic benefit.

Duration (days)
Participants27 patients suffering from cluster headache
Type of publicationMedical journal
Address of author(s)Emergency Headache Center, Head and Neck Clinic, Hôpital Lariboisière, Assistance Publique des Hôpitaux de Paris, France.

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