On this site you will find clinical studies with cannabis or single
cannabinoids in different diseases and case reports on the use of cannabis by
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|Title||Cannabinoids reduce levodopa-induced dyskinesia in Parkinson's disease: a pilot study.|
|Author(s)||Sieradzan KA, Fox SH, Hill M, Dick JP, Crossman AR, Brotchie JM|
|Journal, Volume, Issue||Neurology 2001;57(11):2108-2111|
|Major outcome(s)||significant reduction of levodopa-induced dyskinesia|
The lateral segment of the globus pallidus (GPl) is thought to be overactive in levodopa-induced dyskinesia in PD. Stimulation of cannabinoid receptors in the GPl reduces gamma-aminobutyric acid (GABA) reuptake and enhances GABA transmission and may thus alleviate dyskinesia. In a randomized, double-blind, placebo-controlled, crossover trial (n = 7), the authors demonstrate that the cannabinoid receptor agonist nabilone significantly reduces levodopa-induced dyskinesia in PD.
|Participants||7 patients Parkinson's disease|
|Type of publication|
|Address of author(s)||Department of Neurology, Manchester Royal Infirmary, UK|