Clinical Studies and Case Reports

On this site you will find clinical studies with cannabis or single cannabinoids in different diseases and case reports on the use of cannabis by patients.
You may search for diseases (indications), authors, medication, study design (controlled study, open trial, case report etc.) and other criteria.

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Title Preliminary, open-label, pilot study of add-on oral Δ9-tetrahydrocannabinol in chronic post-traumatic stress disorder.
Author(s)Roitman P, Mechoulam R, Cooper-Kazaz R, Shalev A.
Journal, Volume, IssueClin Drug Investig 2014;34(8):587-91.
Major outcome(s)THC caused significant improvements in post-traumatic stress disorder (PTSD).
IndicationPosttraumatic stress disorderAbstract

BACKGROUND AND OBJECTIVES: Many patients with post-traumatic stress disorder (PTSD) achieve but partial remission with current treatments. Patients with unremitted PTSD show high rates of substance abuse. Marijuana is often used as compassion add-on therapy for treatment-resistant PTSD. This open-label study evaluates the tolerance and safety of orally absorbable Δ(9)-tetrahydrocannabinol (THC) for chronic PTSD. METHODS: Ten outpatients with chronic PTSD, on stable medication, received 5 mg of Δ(9)-THC twice a day as add-on treatment. RESULTS: There were mild adverse effects in three patients, none of which led to treatment discontinuation. The intervention caused a statistically significant improvement in global symptom severity, sleep quality, frequency of nightmares, and PTSD hyperarousal symptoms. CONCLUSIONS: Orally absorbable Δ(9)-THC was safe and well tolerated by patients with chronic PTSD.

Duration (days)
Participants10 patients with posttraumatic stress disorder
DesignOpen study
Type of publicationMedical journal
Address of author(s)Department of Psychiatry, Hadassah Hebrew University Medical Center, Jerusalem, Israel,

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