Clinical Studies and Case Reports

On this site you will find clinical studies with cannabis or single cannabinoids in different diseases and case reports on the use of cannabis by patients.
You may search for diseases (indications), authors, medication, study design (controlled study, open trial, case report etc.) and other criteria.

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TitleImpact of Cannabis Use during Stabilization on Methadone Maintenance Treatment.
Author(s)Scavone JL, Sterling RC, Weinstein SP, Van Bockstaele EJ.
Journal, Volume, IssueAm J Addict 2013;22(4):344-51.
Major outcome(s)Objective ratings of opiate withdrawal decreased in patients using cannabis during stabilization

BACKGROUND AND OBJECTIVES: Illicit drug use, particularly of cannabis, is common
among opiate-dependent individuals and has the potential to impact treatment in a
negative manner.
METHODS: To examine this, patterns of cannabis use prior to and during methadone
maintenance treatment (MMT) were examined to assess possible cannabis-related
effects on MMT, particularly during methadone stabilization. Retrospective chart
analysis was used to examine outpatient records of patients undergoing MMT (n =
91), focusing specifically on past and present cannabis use and its association
with opiate abstinence, methadone dose stabilization, and treatment compliance.
RESULTS: Objective rates of cannabis use were high during methadone induction,
dropping significantly following dose stabilization. History of cannabis use
correlated with cannabis use during MMT but did not negatively impact the
methadone induction process. Pilot data also suggested that objective ratings of
opiate withdrawal decrease in MMT patients using cannabis during stabilization.
CONCLUSIONS AND SCIENTIFIC SIGNIFICANCE: The present findings may point to novel
interventions to be employed during treatment for opiate dependence that
specifically target cannabinoid-opioid system interactions.

Duration (days)
Participants91 patients during methadone maintenance treatment
DesignOpen study
Type of publicationMedical journal
Address of author(s)Department of Neuroscience, Farber Institute for Neurosciences, Thomas Jefferson University, Philadelphia, PA, USA.
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