Clinical Studies and Case Reports

On this site you will find clinical studies with cannabis or single cannabinoids in different diseases and case reports on the use of cannabis by patients.
You may search for diseases (indications), authors, medication, study design (controlled study, open trial, case report etc.) and other criteria.

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TitleHerbal cannabis use in patients labeled as fibromyalgia is associated with negative psychosocial parameters.
Author(s)Ste-Marie PA, Fitzcharles MA, Gamsa A, Ware MA, Shir Y.
Journal, Volume, IssueArthritis Care Res (Hoboken). 2012 Jun 21. doi: 10.1002/acr.21732. [Epub ahead of print]
Major outcome(s)Many patients with fibromyalgia use cannabis products.

OBJECTIVES: Patients with chronic pain, including fibromyalgia (FM), may seek
treatments outside mainstream medicine. Medicinal cannabinoids are popularly
advocated for pain relief but with limited evidence for efficacy in FM. The
extent of use of cannabinoids in FM is unknown. METHODS: We have documented the
self-reported prevalence of cannabinoid use in 457 patients carrying the
diagnosis of FM and referred to a tertiary care pain centre. We validated the
diagnosis of FM and examined the associations of cannabinoid use in these
patients. RESULTS: Cannabinoids were being used by 13% of all patients, 80% of
whom used herbal cannabis (marijuana), 24% used prescription cannabinoids and 3%
used both herbal cannabis and prescription cannabinoids. One third of all males
used cannabinoids. Current unstable mental illness (36% vs. 23%; p=0.002), opioid
drug-seeking behaviour (17% vs. 4%; p=0.001), and male gender (26% vs. 7%;
p=0.0002) were all associated with herbal cannabis use. There was a trend for
cannabinoid users to be unemployed and receiving disability payments. The
diagnosis of FM was validated in 302 patients, with 155 assigned another primary
diagnosis. When the FM group was analyzed separately, significant associations
were lost, but trends remained. CONCLUSION: Cannabinoids were used by 13% of
patients referred with a diagnosis of FM. The association of herbal cannabis use
with negative psychosocial parameters raises questions regarding the motive for
this self-medication practice. Although cannabinoids may offer some therapeutic
effect, caution regarding any recommendation should be exercised pending
clarification of general health and psychosocial problems, especially for those

Duration (days)
Participants457 patients suffering from fibromyalgia
Type of publication
Address of author(s)Alan Edwards Pain Management Unit, McGill University Health Center, Montreal, Quebec, Canada; Faculty of Law, Université de Montréal, Montreal, Quebec, Canada.
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