Clinical Studies and Case Reports

On this site you will find clinical studies with cannabis or single cannabinoids in different diseases and case reports on the use of cannabis by patients.
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TitleAdjuvant topical therapy with a cannabinoid receptor agonist in facial postherpetic neuralgia.
Author(s)Phan NQ, Siepmann D, Gralow I, Ständer S.
Journal, Volume, IssueJ Dtsch Dermatol Ges. 2010 Feb;8(2):88-91.
Major outcome(s)Five of eight patients experienced a good pain relief
MedicationOther cannabinoids

Background: Postherpetic neuralgia is a frequent adverse event in herpes zoster patients and difficult to treat. Conventional analgetic therapy often fails to reduce the burning pain transmitted by unmyelinated nerve fibers. These nerves express cannabinoid receptors which exert a role in modulation of nociceptive symptoms. Therefore, topical therapy with cannabinoid receptor agonist seems likely to suppress local burning pain. Patients and methods: In an open-labeled trial, 8 patients with facial postherpetic neuralgia received a cream containing the cannabinoid receptor agonist N-palmitoylethanolamine. The course of symptoms was scored with the visual analog scale. Results: 5 of 8 patients (62.5 %) experienced a mean pain reduction of 87.8 %. Therapy was tolerated by all patients. No unpleasant sensations or adverse events occurred. Conclusions: Topical cannabinoid receptor agonists are an effective and well-tolerated adjuvant therapy option in postherpetic neuralgia.

Duration (days)
Participants8 patients with post-herpetic neuralgia
DesignOpen study
Type of publicationMedical journal
Address of author(s)Competence Center for the Diagnosis and Treatment of Pruritus, Clinic and Polyclinic for Skin Diseases, University Hospital of Münster, Germany.
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