Clinical Studies and Case Reports

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TitlePalmitoylethanolamide in the Treatment of Chronic Pain Caused by Different Etiopathogenesis.
Author(s)Gatti A, Lazzari M, Gianfelice V, Di Paolo A, Sabato E, Sabato AF.
Journal, Volume, IssuePain Med. 2012 Jul 30. doi: 10.1111/j.1526-4637.2012.01432.x. [Epub ahead of print]
Major outcome(s)Significant pain relief with palmitoylethanolamide (PEA)
MedicationOther cannabinoids

Objective.  To assess the efficacy and safety of palmitoylethanolamide (PEA), an
endogenous fatty acid amide belonging to the N-acylethanolamines family, in
reducing pain severity in patients with pain associated to different pathological
conditions. Methods.  This was an observational study conducted on 610 patients
who were unable to effectively control chronic pain with standard therapies. PEA
(600 mg) was administered twice daily for 3 weeks followed by single daily dosing
for 4 weeks, in addition to standard analgesic therapies or as single therapy.
The primary outcome measure was the mean score pain severity evaluated by the
numeric rating scale. Safety was also evaluated. Results.  PEA treatment
significantly decreased the mean score pain intensity evaluated in all patients
who completed the study. The PEA effect was independent of the pain associated
pathological condition. PEA-induced decrease of pain intensity was present also
in patients without concomitant analgesic therapy. Importantly, PEA showed no
adverse effects. Conclusions.  In this study, PEA was effective and safe in the
management of chronic pain in different pathological conditions.

Duration (days)49
Participants610 patients with chronic pain
DesignOpen study
Type of publicationMedical journal
Address of author(s)Department of Emergency and Admission, Critical Care Medicine, Pain Medicine and Anaesthetic Science. Foundation PTV Polyclinic Tor Vergata. University of Rome "Tor Vergata," Rome, Italy.
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