Clinical Studies and Case Reports

On this site you will find clinical studies with cannabis or single cannabinoids in different diseases and case reports on the use of cannabis by patients.
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TitleMüller-Vahl KR, Schneider U, Emrich HM.
Author(s)Combined treatment of Tourette syndrome with delta-9-THC and dopamine receptor agonists.
Journal, Volume, IssueJ Cannabis Ther 2002;2(3-4):145-54.
Major outcome(s)THC may be combined with neuroleptics
IndicationTourette's syndromeAbstract

Animal studies suggest that cannabinoid receptor agonists might enhance the effect of dopamine receptor antagonists (neuroleptics, NL) in hyperkinetic movement disorders. In Tourette syndrome, NL are the most effective drugs for the treatment of tics. Recent clinical trials demonstrated that delta-9-tetrahydrocannabinol (delta-9-THC) also produces a tic-suppressing effect. In this single case study in a 24 years old female suffering from TS with extreme tics, it is suggested for the first time that delta-9-THC may be useful in augmenting the pharmacological response to atypical NL such as amisulpride and risperidone in TS patients. No serious adverse reactions occurred. Controlled studies are necessary to confirm this initial report.

Duration (days)
Participants1 patient with Tourette's syndrome
DesignUncontrolled case report
Type of publicationMedical journal
Address of author(s)Department of Clinical Psychiatry and Psychotherapy, Medical School Hannover, Germany.
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