Clinical Studies and Case Reports

On this site you will find clinical studies with cannabis or single cannabinoids in different diseases and case reports on the use of cannabis by patients.
You may search for diseases (indications), authors, medication, study design (controlled study, open trial, case report etc.) and other criteria.

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TitleRandomized controlled trial of cannabis-based medicine in spasticity caused by multiple sclerosis
Author(s)Collin C, Davies P, Mutiboko IK, Ratcliffe S, for the Sativex Spasticity in MS Study Group
Journal, Volume, IssueEur J Neurology 2007;14(3):290296.
Major outcome(s)Significantly reduction in spasticity
IndicationSpasticity;Multiple sclerosisAbstract

Symptoms relating to spasticity are common in multiple sclerosis (MS) and can be difficult to treat. We have investigated the efficacy, safety and tolerability of a standardized oromucosal whole plant cannabis-based medicine (CBM) containing Ä-9 tetrahydrocannabinol (THC) and cannabidiol (CBD), upon spasticity in MS. A total of 189 subjects with definite MS and spasticity were randomized to receive daily doses of active preparation (n = 124) or placebo (n = 65) in a double blind study over 6 weeks. The primary endpoint was the change in a daily subject-recorded Numerical Rating Scale of spasticity. Secondary endpoints included a measure of spasticity (Ashworth Score) and a subjective measure of spasm. The primary efficacy analysis on the intention to treat (ITT) population (n = 184) showed the active preparation to be significantly superior (P = 0.048). Secondary efficacy measures were all in favour of active preparation but did not achieve statistical significance. The responder analysis favoured active preparation, 40% of subjects achieved >30% benefit (P = 0.014). Eight withdrawals were attributed to adverse events (AEs); six were on active preparation and two on placebo. We conclude that this CBM may represent a useful new agent for treatment of the symptomatic relief of spasticity in MS.

Dose(s)25 mg (mean)
Duration (days)42
Participants189 subjects with MS and spasticity
DesignControlled study
Type of publicationMedical journal
Address of author(s)Christine Collin, Department of Neurorehabilitation, Royal Berkshire and Battle NHS Trust, London Road Reading, Berkshire RG1 5AN, UK (tel.: 0118 322 5367; fax: 0118 322 6751; e-mail:
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