Clinical Studies and Case Reports

On this site you will find clinical studies with cannabis or single cannabinoids in different diseases and case reports on the use of cannabis by patients.
You may search for diseases (indications), authors, medication, study design (controlled study, open trial, case report etc.) and other criteria.

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TitleTHC improves appetite and reverses weight loss in AIDS patients
Author(s)Dejesus E, Rodwick BM, Bowers D, Cohen CJ, Pearce D
Journal, Volume, IssueJ Int Assoc Physicians AIDS Care 2007;6(2):95-100.
Major outcome(s)THC improved appetite and weight and reduced nausea
IndicationNausea/vomiting;Appetite loss/weight loss;HIV/AIDSAbstract

Objective: To determine whether dronabinol affects appetite and weight status in patients living with HIV/AIDS. METHODS: A retrospective chart review was conducted to analyze weight and appetite changes and nausea status in patients with HIV/AIDS who received dronabinol for 3 to 12 months from January 11, 1993, to March 17, 2003. RESULTS: Of the 117 patients who lost weight before baseline, 63% maintained or gained weight. In patients receiving dronabinol for 1 year, the mean weight gain (+/- SD) was 3.7 +/- 10.6 lb. The percentage of patients experiencing loss of appetite decreased significantly from 71% at baseline to 26% at 1 month (P < .001) and continued to decline throughout the trial. The percentage of patients experiencing nausea at baseline (38%) decreased consistently from week 2 on; this change from baseline was significant at month 6 (P = .031). CONCLUSION: When taken for 3 months to 1 year, dronabinol significantly improves appetite and reverses weight loss in patients living with HIV/AIDS.

Duration (days)90-365
Participants117 patients with HIV/AIDS
DesignOpen study
Type of publicationMedical journal
Address of author(s)Orlando Immunology Center, Orlando, Florida,
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