Clinical Studies and Case Reports

On this site you will find clinical studies with cannabis or single cannabinoids in different diseases and case reports on the use of cannabis by patients.
You may search for diseases (indications), authors, medication, study design (controlled study, open trial, case report etc.) and other criteria.

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TitleThe effect of cannabis on urge incontinence in patients with multiple sclerosis: a multicentre, randomised placebo-controlled trial (CAMS-LUTS).
Author(s)Freeman RM, Adekanmi O, Waterfield MR, Waterfield AE, Wright D, Zajicek J.
Journal, Volume, IssueInt Urogynecol J Pelvic Floor Dysfunct. 2006 Mar 22; [Epub ahead of print]
Major outcome(s)Cannabis and dronabinol caused a significant reduction in incontinence
IndicationMultiple sclerosisAbstract

Objective: To test whether cannabinoids reduce urge incontinence episodes without affecting voiding in patients with multiple sclerosis. This was part of the multicentre trial of the Cannabinoids in Multiple Sclerosis (CAMS) study. Subjects and methods: The CAMS study randomised 630 patients to receive oral administration of cannabis extract, Delta(9)-tetrahydrocannabinol (THC) or matched placebo. For this substudy subjects completed incontinence diaries. Results: All three groups showed a significant reduction, p<0.01, in adjusted episode rate (i.e. correcting for baseline imbalance) from baseline to the end of treatment: cannabis extract, 38%; THC, 33%; and placebo, 18%. Both active treatments showed significant effects over placebo (cannabis extract, p=0.005; THC, p=0.039). Conclusion: The findings are suggestive of a clinical effect of cannabis on incontinence episodes in patients with MS. This is in contrast to the negative finding of the CAMS study, where no difference was seen in the primary outcome of spasticity.

Dose(s)max. 10-25 mg daily
Duration (days)105
Participants630 MS patients
DesignControlled study
Type of publicationMedical journal
Address of author(s)Urogynaecology Unit, Derriford Hospital, Plymouth, Devon, UK,
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