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|Title||Treatment of Tourette's syndrome with delta-9-tetrahydrocannabinol.|
|Author(s)||Muller-Vahl KR, Schneider U, Kolbe H, Emrich HM.|
|Journal, Volume, Issue||Am J Psychiatry. 1999 Mar;156(3):495.|
|Major outcome(s)||Improvement of tics and obsessive-compulsive behavior|
To the Editor: Tourette's syndrome is a complex neuropsychiatric disorder of unknown etiology. Earlier reports suggested beneficial effects in Tourette's syndrome when smoking marijuana (Cannabis sativa) (1, 2, 3). We report a successful treatment of Tourette's syndrome with delta-9-tetrahydrocannabinol (9-THC), the major psychoactive ingredient of marijuana.
Mr. A was treated once with 10 mg of 9-THC. (He was unmedicated and had stopped smoking marijuana 3 days before.) Using the section on tic symptoms of the Tourette's Syndrome Global Scale, we found that Mr. A's total tic severity score was 41 before treatment and was reduced to 7 just 2 hours after treatment. Both motor and vocal tics improved and coprolalia disappeared. The improvement began 30 minutes after treatment and lasted for about 7 hours; no adverse effects occurred. To measure cognitive functions, we performed neuropsychological tests, which showed improved signal detection and sustained attention and reaction time after treatment. Mr. A himself noted an improvement of motor and vocal tics of about 70%. Furthermore, he felt an amelioration in attention, impulse control, obsessive-compulsive behavior, and premonitory feeling.
|Participants||A man with Tourette's syndrome|
|Design||Uncontrolled case report|
|Type of publication||Medical journal|
|Address of author(s)||Abteilung für Klinische Psychiatrie und Psychotherapie, Medizinische Hochschule Hannover, Germany.|