Clinical Studies and Case Reports

On this site you will find clinical studies with cannabis or single cannabinoids in different diseases and case reports on the use of cannabis by patients.
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TitleCannabinoids: possible role in patho-physiology and therapy of Gilles de la Tourette syndrome.
Author(s)Muller-Vahl KR, Kolbe H, Schneider U, Emrich HM.
Journal, Volume, IssueActa Psychiatr Scand. 1998 Dec;98(6):502-6.
Major outcome(s)Evidence that marijuana improves tics and behavioural disorders in TS.
IndicationTourette's syndromeAbstract

High densities of cannabinoid receptors were found in the basal ganglia and hippocampus, indicating a putative functional role of cannabinoids in movement and behaviour. Anecdotal reports suggested beneficial effects of marijuana in Tourette's syndrome (TS). We therefore interviewed 64 TS patients with regard to use of marijuana and its influence on TS symptomatology. Of 17 patients (27%) who reported prior use of marijuana, 14 subjects (82%) experienced a reduction or complete remission of motor and vocal tics and an amelioration of premonitory urges and obsessive-compulsive symptoms. Our results provide more evidence that marijuana improves tics and behavioural disorders in TS. It can be speculated that cannabinoids might act through specific receptors, and that the cannabinoid system might play a major role in TS pathology.

Duration (days)
Participants64 TS patients
Type of publicationMedical journal
Address of author(s)Department of Clinical Psychiatry and Psychotherapy, Medical School Hannover, Germany.
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