On this site you will find clinical studies with cannabis or single
cannabinoids in different diseases and case reports on the use of cannabis by
patients.
You may search for diseases (indications), authors, medication,
study design (controlled study, open trial, case report etc.) and other criteria.
| Diagnosis | Title | Author(s) | Year | Medication(s) | Design | Major outcome(s) | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Show | Cancer; Appetite loss/weight loss; Depression | Regelson W, Butler JR, Schulz J, Kirk T, Peek L, Green ML, Zalis MO | 1976 | Delta-9-THC | Controlled study | weight gain with THC; weight los with placebo | |||||||
| Show | Dependency/withdrawal | Hill KP et al. | 2017 | Nabilone | Open study | Nabilone reduced cannabis use in cannabis-dependent persons | |||||||
| Show | Pain | Medina SH, Nadarajah V, Jauregui JJ, Smuda MP, Foster M, Meredith SJ, Packer JD, Henn RF 3rd. | 2018 | Cannabis | Open study | Cannabis use was associated with less pain after orthopaedic surgery | |||||||
| Show | Alcohol and Cannabis Use Alter Pulmonary Innate Immunity. | 2018 | Cannabis | Open study | Smoking of cannabis may promote airway inflammation | ||||||||
| Show | Anxiety;Posttraumatic stress disorder | Cannabinoid facilitation of fear extinction memory recall in humans. | Rabinak CA, Angstadt M, Sripada CS, Abelson JL, Liberzon I, Milad MR, Phan KL. | 2012 | Delta-9-THC | Controlled study | THC prevented the recovery of fear in this experiment of extinction learning. | ||||||
| Show | Multiple sclerosis;Spasticity | Endocannabinoid system modulator use in everyday clinical practice in the UK and Spain. | García-Merino A. | 2013 | Cannabis | Open study | Sativex appears to be a well-tolerated and useful add-on therapy in patients with spasticity due to multiple sclerosis. | ||||||
| Show | Bipolar disorders | Joint Effects: A Pilot Investigation of the Impact of Bipolar Disorder and Marijuana Use on Cognitive Function and Mood. | Sagar KA, Dahlgren MK, Racine MT, Dreman MW, Olson DP, Gruber SA. | 2016 | Cannabis | Controlled study | Cannabis showed beneficial effects in bipolar disorder | ||||||
| Show | Posttraumatic stress disorder | Preliminary, open-label, pilot study of add-on oral Δ9-tetrahydrocannabinol in chronic post-traumatic stress disorder. | Roitman P, Mechoulam R, Cooper-Kazaz R, Shalev A. | 2014 | Delta-9-THC | Open study | THC caused significant improvements in post-traumatic stress disorder (PTSD). | ||||||
| Show | Pain | A case of cannabinoid rotation in a young woman with chronic cystitis | Krenn H Daha LK Oczenski W Fitzgerald R D | 2003 | Delta-9-THC;Nabilone | Uncontrolled case report | THC reduced pain with low side effects; nabilone caused strong psychic side effects | ||||||
| Show | Spasticity | A casuistic rationale for the treatment of spastic and myocloni in a childhood neurodegenerative disease: neuronal ceroid lipofuscinosis of the type Jansky-Bielschowsky. | Lorenz R. | 2002 | Delta-9-THC | Uncontrolled case report | Improvement of spasticity | ||||||
| Show | Psychosis/schizophrenia | A controlled family study of cannabis users with and without psychosis. | Proal AC, Fleming J, Galvez-Buccollini JA, Delisi LE. | 2013 | Cannabis | Controlled study | Cannabis does not cause psychosis by itself | ||||||
| Show | Nausea/vomiting;Cancer;Cancer chemotherapy | A cross-over comparison of nabilone and prochlorperazine for emesis induced by cancer chemotherapy. | Niiranen A, Mattson K. | 1985 | Nabilone | Controlled study | Nabilone is a moderately effective anti-emetic drug | ||||||
| Show | Anxiety;Depression;Pain;Sleep disorder | A Cross-Sectional Study of Cannabidiol Users. | Corroon J, Phillips JA. | 2018 | Cannabidiol | Survey | CBD is mostly used against pain, sleep disorders, anxiety and depression | ||||||
| Show | Nausea/vomiting | A double-blind randomised cross-over comparison of nabilone and metoclopramide in the control of radiation-induced nausea. | Priestman SG, Priestman TJ, Canney PA. | 1987 | Nabilone | Controlled study | Nabilone similar effective as metoclopramide | ||||||
| Show | Appetite loss/weight loss | A double-blind trial of delta 9-tetrahydrocannabinol in primary anorexia nervosa. | Gross H, Ebert MH, Faden VB, Goldberg SC, Kaye WH, Caine ED, Hawks R, Zinberg N | 1983 | Delta-9-THC | Controlled study | no significant difference between THC and diazepam | ||||||
| Show | Cancer;Cancer chemotherapy | A double-blind, controlled trial of nabilone vs. prochlorperazine for refractory emesis induced by cancer chemotherapy. | Johansson R, Kilkku P, Groenroos M. | 1982 | Nabilone | Controlled study | Severity of nausea and number of vomiting ejections and dry retching episodes were significantly less under nabilone. | ||||||
| Show | Pain | A double-blind, placebo-controlled, crossover pilot trial with extension using an oral mucosal cannabinoid extract for treatment of chemotherapy-induced neuropathic pain. | Lynch ME, Cesar-Rittenberg P, Hohmann AG. | 2014 | Cannabis | Controlled study | Reduction in pain intensity | ||||||
| Show | Cancer chemotherapy;Pain | A Double-Blind, Placebo-Controlled, Crossover Pilot Trial With Extension Using an Oral Mucosal Cannabinoid Extract for Treatment of Chemotherapy-Induced Neuropathic Pain. | Lynch ME, Cesar-Rittenberg P, Hohmann AG. | 2013 | Cannabis | Controlled study | Five patients tended to respond to a treatment with cannabis | ||||||
| Show | Pain | A double-blind, randomized, placebo-controlled, parallel group study of THC/CBD spray in peripheral neuropathic pain treatment | Serpell M, Ratcliffe S, Hovorka J, Schofield M, Taylor L, Lauder H, Ehler E | 2014 | Cannabis | Controlled study | Significant improvements in pain, sleep quality and subjective evaluations of patients. | ||||||
| Show | Multiple sclerosis;Spasticity | A double-blind, randomized, placebo-controlled, parallel-group study of Sativex, in subjects with symptoms of spasticity due to multiple sclerosis | Collin C, Ehler E, Waberzinek G, Alsindi Z, Davies P, Powell K, Notcutt W, O'Leary C, Ratcliffe S, Nováková I, Zapletalova O, Piková J, Ambler Z | 2010 | Cannabis | Controlled study | Significant reduction in treatment-resistant spasticity. | ||||||
| Show | Multiple sclerosis;Pain | A double-blind, randomized, placebo-controlled, parallel-group study of THC/CBD oromucosal spray in combination with the existing treatment regimen, in the relief of central neuropathic pain in patients with multiple sclerosis. | Langford RM, Mares J, Novotna A, Vachova M, Novakova I, Notcutt W, Ratcliffe S | 2013 | Cannabis | Controlled study | No significant difference between placebo and Sativex in Phase A; Phase B demonstrated an analgesic effect. | ||||||
| Show | Asthma | A longitudinal study of cannabis use increasing the use of asthma medication in young Norwegian adults. | Bramness JG, von Soest T. | 2019 | Cannabis | Survey | Smoking of cannabis may be a risk factor for asthma | ||||||
| Show | A meta-analysis of the crash risk of cannabis-positive drivers in culpability studies-Avoiding interpretational bias. | Rogeberg O. | 2018 | Cannabis | The risk for traffic accidents caused by cannabis is low | ||||||||
| Show | Nausea/vomiting;Cancer;Cancer chemotherapy | A multi-institutional Phase III study of nabilone vs. placebo in chemotherapy-induced nausea and vomiting. | Jones SE, Durant JR, Greco FA, Robertone A. | 1982 | Nabilone | Controlled study | Nabilone is an effective antiemetic agent for chemotherapy-induced nausea and vomiting. | ||||||
| Show | Pain | A multicenter dose-escalation study of the analgesic and adverse effects of an oral cannabis extract (Cannador) for postoperative pain management. | Holdcroft A, Maze M, Dore C, Tebbs S, Thompson S. | 2006 | Cannabis | Controlled study | The optimal dose was 10 mg Cannador, effectively reducing postoperative pain without serious side effects. | ||||||
| Show | Anxiety;Depression | A naturalistic examination of the perceived effects of cannabis on negative affect | Cuttler C, Spradlin A, McLaughlin RJ | 2018 | Cannabis | Open study | Acute use of cannabis may reduce anxiety and depression | ||||||
| Show | Multiple sclerosis;Spasticity | A new multiple sclerosis spasticity treatment option: effect in everyday clinical practice and cost-effectiveness in Germany. | Flachenecker P. | 2013 | Cannabis | Open study | The cannabis extract sativex is effective in a large number of patients and well-tolerated in the long-term. | ||||||
| Show | Appetite loss/weight loss;Cancer | A phase II study of delta-9-tetrahydrocannabinol for appetite stimulation in cancer-associated anorexia. | Nelson K, Walsh D, Deeter P, Sheehan F | 1994 | Delta-9-THC | Open study | increase of appetite in 13 patients | ||||||
| Show | Cancer | A pilot clinical study of Delta(9)-tetrahydrocannabinol in patients with recurrent glioblastoma multiforme. | Guzman M, Duarte MJ, Blazquez C, Ravina J, Rosa MC, Galve-Roperh I, Sanchez C, Velasco G, Gonzalez-Feria L. | 2006 | Delta-9-THC | Open study | THC was well tolerated in this pilot study of intrakranial cannabinoid administration | ||||||
| Show | Appetite loss/weight loss;HIV/AIDS | A pilot study of the effects of cannabis on appetite hormones in HIV-infected adult men | Riggs PK, Vaida F, Rossi SS, Sorkin LS, Gouaux B, Grant I, Ellis RJ | 2012 | Cannabis | Controlled study | Cannabis administration was associated with significant increases in plasma levels of ghrelin and leptin, and decreases in PYY, but did not significantly influence insulin levels | ||||||
| Show | HIV/AIDS | A pilot study of the effects of cannabis on appetite hormones in HIV-infected adult men. | Riggs PK, Vaida F, Rossi SS, Sorkin LS, Gouaux B, Grant I, Ellis RJ. | 2011 | Cannabis | Controlled study | Cannabis modulates the concentration of appetite hormones | ||||||
| Show | Cancer | A population-based case-control study of marijuana use and head and neck squamous cell carcinoma. | Liang C, McClean MD, Marsit C, Christensen B, Peters E, Nelson HH, Kelsey KT. | 2009 | Cannabis | Survey | Subjects who used cannabis had a reduced cancer risk. | ||||||
| Show | Spasticity;Spinal cord injury;Multiple sclerosis;Pain | A preliminary controlled study to determine whether whole-plant cannabis extracts can improve intractable neurogenic symptoms. | Wade DT, Robson P, House H, Makela P, Aram J. | 2003 | Cannabis;Delta-9-THC;Cannabidiol | Controlled study | Pain relief associated with both THC and CBD was significantly superior to placebo. Impaired bladder control, muscle spasms and spasticity were improved by cannabis in some patients | ||||||
| Show | Pain | A preliminary evaluation of the relationship of cannabinoid blood concentrations with the analgesic response to vaporized cannabis. | Wilsey BL, Deutsch R, Samara E, Marcotte TD, Barnes AJ, Huestis MA, Le D. | 2016 | Delta-9-THC | Controlled study | Moderate relationship between THC concentrations and reduction of pain | ||||||
| Show | Nausea/vomiting;Cancer;Cancer chemotherapy | A prospective evaluation of delta-9-tetrahydrocannabinol as an antiemetic in patients receiving adriamycin and cytoxan chemotherapy. | Chang AE, Shiling DJ, Stillman RC, Goldberg NH, Seipp CA, Barofsky I, Rosenberg | 1981 | Delta-9-THC | Controlled study | no significant reduction of the number of vomiting, volume of emesis, degree of nausea, or duration of nausea | ||||||
| Show | Pain | A prospective identification of neuropathic pain in specific chronic polyneuropathy syndromes and response to pharmacological therapy. | Toth C, Au S. | 2008 | Cannabis;Nabilone | Open study | Similar treatment effects and side effects of cannabinoids compared to other medications | ||||||
| Show | Epilepsy | A prospective open-label trial of a CBD/THC cannabis oil in dravet syndrome | McCoy B. et al. | 2018 | Delta-9-THC;Cannabidiol | Open study | Cannabis extract with high CBD and low THC content effective in childhood epilepsy | ||||||
| Show | A Prospective Study of Humoral and Cellular Immune Responses to Hepatitis B Vaccination in Habitual Marijuana Smokers | Kiertscher SM, Gangalum PR, Ibrahim G, Tashkin DP, Roth MD | 2018 | Cannabis | Open study | ||||||||
| Show | A quasi-experimental evaluation of marijuana policies and youth marijuana use | Coley RL. et al. | 2019 | Cannabis | Open study | Young people may use less cannabis in the US states with medical cannabis laws | |||||||
| Show | Multiple sclerosis;Pain;Spasticity | A questionnaire survey of patients and carers of patients prescribed Sativex as an unlicensed medicine. | Notcutt WG. | 2012 | Cannabis | Survey | Most respondents experienced improvements across a range of symptoms. | ||||||
| Show | Spasticity;Multiple sclerosis | A randomised controlled study of Sativex® in patients with symptoms of spasticity due to multiple sclerosis | Collin C, Ambler Z, Kent R, McCalla R. | 2006 | Cannabis | Controlled study | Spasticity of patients who received cannabis and complied with the study protocol was significantly reduced compared to placebo. | ||||||
| Show | A randomised controlled trial of vaporised Δ9-tetrahydrocannabinol and cannabidiol alone and in combination in frequent and infrequent cannabis users: acute intoxication effects. | Solowij N, et al. | 2019 | Controlled study | Low doses of CBD increased psychedelic effects of THC and high CBD doses reduced these effects | ||||||||
| Show | Nausea/vomiting;Cancer;Cancer chemotherapy | A randomised multicentre single blind comparison of a cannabinoid anti-emetic (levonantradol) with chlorpromazine in patients receiving their first cytotoxic chemotherapy. | Hutcheon AW, Palmer JB, Soukop M, Cunningham D, McArdle C, Welsh J, Stuart F, Sangster G, Kaye S, Charlton D, et al. | 1983 | Other cannabinoids | Controlled study | 0.5 mg levonantradol was a more effective antiemtic than 25 mg chlorpromazine | ||||||
| Show | Nausea/vomiting;Cancer;Cancer chemotherapy | A randomized trial of oral nabilone and prochlorperazine compared to intravenous metoclopramide and dexamethasone in the treatment of nausea and vomiting induced by chemotherapy regimens containing cisplatin or cisplatin analogues. | Cunningham D, Bradley CJ, Forrest GJ, Hutcheon AW, Adams L, Sneddon M, Harding M, Kerr DJ, Soukop M, Kaye SB. | 1988 | Nabilone | Open study | Metoclopramide/dexamethasone superior to nabilone/prochlorperazine | ||||||
| Show | Pain | A Randomized, Controlled Study to Investigate the Analgesic Efficacy of Single Doses of the Cannabinoid Receptor-2 Agonist GW842166, Ibuprofen or Placebo in Patients With Acute Pain Following Third Molar Tooth Extraction. | Ostenfeld T, Price J, Albanese M, Bullman J, Guillard F, Meyer I, Leeson R, Costantin C, Ziviani L, Nocini PF, Milleri S. | 2011 | Other cannabinoids | Controlled study | No superior analgetic effect of the synthetic cannabinoid GW842166 over placebo. | ||||||
| Show | Multiple sclerosis;Spasticity | A randomized, double-blind, placebo-controlled, parallel-group, enriched-design study of nabiximols* (Sativex(®) ), as add-on therapy, in subjects with refractory spasticity caused by multiple sclerosis. | Novotna A, Mares J, Ratcliffe S, Novakova I, Vachova M, Zapletalova O, Gasperini C, Pozzilli C, Cefaro L, Comi G, Rossi P, Ambler Z, Stelmasiak Z, Erdmann A, Montalban X, Klimek A, Davies P; the Sativex Spasticity Study Group. | 2011 | Cannabis | Controlled study | The cannabis extract significantly reduced spasticity. | ||||||
| Show | A Randomized, Double-blind, Placebo-controlled, Parallel-group, Pilot Study of Cannabidiol-rich Botanical Extract in the Symptomatic Treatment of Ulcerative Colitis | Irving PM et al. | 2018 | Cannabidiol | Controlled study | A CBD-rich cannabis extract improved symptoms of ulcerative colitis in a controlled clinical study | |||||||
| Show | A Randomized, Double-blind, Placebo-controlled, Parallel-group, Pilot Study of Cannabidiol-rich Botanical Extract in the Symptomatic Treatment of Ulcerative Colitis | Irving PM et al. | 2018 | Cannabidiol | Controlled study | A CBD-rich cannabis extract improved symptoms of ulcerative colitis in a controlled clinical study | |||||||
| Show | Spasticity;Spinal cord injury | A randomized, double-blinded, crossover pilot study assessing the effect of nabilone on spasticity in persons with spinal cord injury. | Pooyania S, Ethans K, Szturm T, Casey A, Perry D. | 2010 | Nabilone | Controlled study | There was a significant decrease in spasticity by nabilone. | ||||||
| Show | Pain | A Randomized, Placebo-Controlled, Crossover Trial of Cannabis Cigarettes in Neuropathic Pain. | Wilsey B, Marcotte T, Tsodikov A, Millman J, Bentley H, Gouaux B, Fishman S. | 2008 | Cannabis | Controlled study | Significant improvement of pain | ||||||
| Show | Nausea/vomiting | A randomized-controlled trial of nabilone for the prevention of acute postoperative nausea and vomiting in elective surgery | Levin DN, Dulberg Z, Chan AW, Hare GM, Mazer CD, Hong A | 2017 | Nabilone | Controlled study | Nabilone was not effective in reducing postoperative nausea and vomiting | ||||||
| Show | A single dose of cannabidiol reduces blood pressure in healthy volunteers in a randomized crossover study | Jadoon KA, Tan GD, O'Sullivan SE | 2017 | Cannabidiol | Controlled study | CBD reduces blood pressure in healthy people | |||||||
| Show | Pain | A study of levonantradol, a cannabinol derivative, for analgesia in post operative pain. | Kantor TG, Hopper M. | 1981 | Other cannabinoids | Controlled study | Levonantradol has analgetic activity but may have central nervous system adverse effects in humans. | ||||||
| Show | Dependency/withdrawal | A Survey of Cannabis Acute Effects and Withdrawal Symptoms: Differential Responses Across User Types and Age. | Sexton M, Cuttler C, Mischley LK. | 2018 | Cannabis | Survey | Differences between medical and recreational cannabis users with regard to withdrawal | ||||||
| Show | Multiple sclerosis | Acute and chronic effects of cannabis based medicinal extract on refractory lower urinary tract dysfunction in patients with advanced multiple sclerosis – early results | Brady CM, DasGupta R, Wiseman OJ, Berkley KJ, Fowler CJ | 2001 | Cannabis | Open study | Mean maximum cystometric capacity increased | ||||||
| Show | Asthma | Acute and subacute bronchial effects of oral cannabinoids. | Gong H Jr, Tashkin DP, Simmons MS, Calvarese B, Shapiro BJ | 1984 | Delta-9-THC | Open study | acute bronchodilator activity of delta 9-THC; no effect of cannabidiol; daily use of delta 9-THC not associated with tolerance | ||||||
| Show | Acute effects of a single, oral dose of d9-tetrahydrocannabinol (THC) and cannabidiol (CBD) administration in healthy volunteers. | Martín-Santos R, Crippa JA, Batalla A, Bhattacharyya S, Atakan Z, Borgwardt S, Allen P, Seal M, Langohr K, Farré M, Zuardi AW, McGuire P. | 2012 | Delta-9-THC;Cannabidiol | Controlled study | CBD does not cause significant side effects | |||||||
| Show | Acute effects of delta-9-tetrahydrocannabinol, cannabidiol and their combination on facial emotion recognition: a randomised, double-blind, placebo-controlled study in cannabis users. | Hindocha C, Freeman TP, Schafer G, Gardener C, Das RK, Morgan CJ, Curran HV. | 2015 | Cannabis;Delta-9-THC;Cannabidiol | Controlled study | Improvement of recognition of emotional facial affect by CBD and attenuation of the impairment induced by THC | |||||||
| Show | Asthma | Acute effects of smoked marijuana and oral delta9-tetrahydrocannabinol on specific airway conductance in asthmatic subjects. | Tashkin DP, Shapiro BJ, Frank IM. | 1974 | Cannabis;Delta-9-THC;Cannabidiol | Controlled study | Smoked marijuana and oral THC caused significant bronchodilation of at least 2 hours duration. | ||||||
| Show | Acute Pharmacokinetic Profile of Smoked and Vaporized Cannabis in Human Blood and Oral Fluid. | Spindle TR. et al. | 2019 | Cannabis | Controlled study | Vaporisation may be more effective than smoking cannabis | |||||||
| Show | Attention-deficit/hyperactivity disorder | ADHD, depression, and substance abuse risk among beginning college students. | Mochrie KD, Whited MH, Cellucci T, Freeman T, Corson AT. | 2018 | Cannabis | Survey | Students with ADHD are more likely to use cannabis | ||||||
| Show | Appetite loss/weight loss;Cancer;Pain | Adjunctive nabilone in cancer pain and symptom management: a prospective observational study using propensity scoring. | Maida V, Ennis M, Irani S, Corbo M, Dolzhykov M. | 2008 | Nabilone | Open study | Significant improvement of pain | ||||||
| Show | Pain | Adjuvant topical therapy with a cannabinoid receptor agonist in facial postherpetic neuralgia. | Phan NQ, Siepmann D, Gralow I, Ständer S. | 2010 | Other cannabinoids | Open study | Five of eight patients experienced a good pain relief | ||||||
| Show | Aerobic Fitness Level Moderates the Association Between Cannabis Use and Executive Functioning and Psychomotor Speed Following Abstinence in Adolescents and Young Adults. | Wade NE, Wallace AL, Swartz AM, Lisdahl KM. | 2018 | Cannabis | Open study | Negative effects of cannabis use on cognition in young people is lower in those with good physical fitness | |||||||
| Show | Nausea/vomiting | Amelioration of cancer chemotherapy-induced nausea and vomiting by delta-9-tetrahydrocannabinol. | Ekert H, Waters KD, Jurk IH, Mobilia J, Loughnan P | 1979 | Delta-9-THC | Controlled study | THC was effective in reducing nausea and vomiting but not in all patients | ||||||
| Show | Cancer chemotherapy; Nausea/vomiting | An efficient new cannabinoid antiemetic in pediatric oncology. | Abrahamov A, Abrahamov A, Mechoulam R | 1995 | Delta-9-THC | Open study | complete prevention of emesis | ||||||
| Show | Pain | An efficient randomised, placebo-controlled clinical trial with the irreversible fatty acid amide hydrolase-1 inhibitor PF-04457845, which modulates endocannabinoids but fails to induce effective analgesia in patients with pain due to osteoarthritis of the knee. | Huggins JP, Smart TS, Langman S, Taylor L, Young T. | 2012 | Other cannabinoids | Controlled study | A FAAH inhibitor was not more effective than a placebo. | ||||||
| Show | Pain | An experimental randomized study on the analgesic effects of pharmaceutical-grade cannabis in chronic pain patients with fibromyalgia. | van de Donk T, Niesters M, Kowal MA, Olofsen E, Dahan A, van Velzen M. | 2018 | Cannabis | Controlled study | Cannabis rich in THC may be useful in the treatment of fibromyalgia | ||||||
| Show | Pain;Spinal cord injury | An Exploratory Human Laboratory Experiment Evaluating Vaporized Cannabis in the Treatment of Neuropathic Pain From Spinal Cord Injury and Disease. | Wilsey B, Marcotte TD, Deutsch R, Zhao H, Prasad H, Phan A. | 2016 | Cannabis | Controlled study | Inhaled cannabis reduces neuropathic pain in patients with spinal cord injury | ||||||
| Show | Nausea/vomiting;Cancer | An initial evaluation of Nabilone in the control of radiotherapy-induced nausea and vomiting. | Priestman TJ, Priestman SG. | 1984 | Nabilone | Open study | Patients who did not respond to metaclopramide responded to nabilone. | ||||||
| Show | Pain | An Open-Label Comparison of Nabilone and Gabapentin as Adjuvant Therapy or Monotherapy in the Management of Neuropathic Pain in Patients with Peripheral Neuropathy. | Bestard JA, Toth CC. | 2010 | Nabilone | Open study | The benefits of nabilone are similar as gabapentin | ||||||
| Show | Cancer;Pain | An open-label extension study to investigate the long-term safety and tolerability of THC/CBD oromucosal spray and oromucosal THC spray in patients with terminal cancer-related pain refractory to strong opioid analgesics | Johnson JR, Lossignol D, Burnell-Nugent M, Fallon MT | 2013 | Cannabis | Open study | The cannabis extract Sativex was generally well tolerated, with no evidence of a loss of effect for pain relief. | ||||||
| Show | Multiple sclerosis | An open-label pilot study of cannabis-based extracts for bladder dysfunction in advanced multiple sclerosis. | Brady CM, DasGupta R, Dalton C, Wiseman OJ, Berkley KJ, Fowler CJ. | 2004 | Cannabis | Open study | Urinary urgency, the number and volume of incontinence episodes, frequency and nocturia all decreased. | ||||||
| Show | Pain | Analgesic and antihyperalgesic effects of nabilone on experimental heat pain. | Redmond WJ, Goffaux P, Potvin S, Marchand S. | 2008 | Nabilone | Controlled study | Nabilone did not reduce experimental heat pain | ||||||
| Show | Cancer; Pain | Analgesic effect of delta-9-tetrahydrocannabinol. | Noyes R Jr, Brunk SF, Baram DA, Canter A | 1975 | Delta-9-THC | Controlled study | pain relief with 15-20 mg THC | ||||||
| Show | Multiple sclerosis;Pain | Analgesic effect of the cannabinoid analogue nabilone is not mediated by opioid receptors. | Hamann W, di Vadi PP. | 1999 | Nabilone | Open study | Relieve of pain | ||||||
| Show | Pain | Analgesic effect of the synthetic cannabinoid CT-3 on chronic neuropathic pain: a randomized controlled trial. | Karst M, Salim K, Burstein S, Conrad I, Hoy L, Schneider U. | 2003 | Other cannabinoids | Controlled study | Significant reduction of pain | ||||||
| Show | Appetite loss/weight loss | Anorexia of aging in long term care: is dronabinol an effective appetite stimulant? - a pilot study. | Wilson MM, Philpot C, Morley JE | 2007 | Delta-9-THC | Open study | A trend towards weight gain | ||||||
| Show | Nausea/vomiting;Cancer;Cancer chemotherapy | Anti-emetic efficacy and toxicity of nabilone, a synthetic cannabinoid, in lung cancer chemotherapy. | Ahmedzai S, Carlyle DL, Calder IT, Moran F. | 1983 | Nabilone | Controlled study | Symptom scores were significantly better for patients on nabilone for nausea, retching and vomiting. | ||||||
| Show | Epilepsy | Anticonvulsant effect of cannabidiol. | Ames FR, Cridland S | 1986 | Cannabidiol | Controlled study | no significant effect in addition to standard medication | ||||||
| Show | Epilepsy | Anticonvulsant nature of marihuana smoking. | Consroe PF, Wood GC, Buchsbaum H | 1975 | Cannabis | Uncontrolled case report | Cannabis was able to control seizures in conjunction with phenobarbital and diphenylhydantoin. | ||||||
| Show | Cancer chemotherapy; Nausea/vomiting | Antiemetic effect of delta-9-tetrahydrocannabinol in patients receiving cancer chemotherapy. | Sallan SE, Zinberg NE, Frei E 3d | 1975 | Delta-9-THC | Controlled study | for patients completing the study there were 5 complete responses (no vomiting) and 7 partial responses (50% decrease of vomiting) of overall 15 courses | ||||||
| Show | Cancer chemotherapy; Nausea/vomiting | Antiemetic effect of tetrahydrocannabinol. Compared with placebo and prochlorperazine in chemotherapy-associated nausea and emesis. | Orr LE, McKernan JF, Bloome B | 1980 | Delta-9-THC | Controlled study | no nausea and no vomiting (complete response) in 73% (40/55 courses) in THC group | ||||||
| Show | Cancer;Cancer chemotherapy | Antiemetic efficacy of levonantradol compared to delta-9-tetrahydrocannabinol for chemotherapy-induced nausea and vomiting. | Citron ML, Herman TS, Vreeland F, Krasnow SH, Fossieck BE Jr, Harwood S, Franklin R, Cohen MH. | 1985 | Delta-9-THC;Other cannabinoids | Controlled study | Levonantradol appears to be at least as effective an antiemetic as THC ; well-tolerated side-effects. | ||||||
| Show | Nausea/vomiting | Antiemetic efficacy of smoked marijuana: subjective and behavioral effects on nausea induced by syrup of ipecac. | Soderpalm AH, Schuster A, de Wit H | 2001 | Cannabis | Controlled study | Ondansetron superior to cannabis in reducing nausea and vomiting | ||||||
| Show | Nausea/vomiting;Cancer;Cancer chemotherapy | Antiemetic therapy: a review of recent studies and a report of a random assignment trial comparing metoclopramide with delta-9-tetrahydrocannabinol. | Gralla RJ, Tyson LB, Bordin LA, Clark RA, Kelsen DP, Kris MG, Kalman LB, Groshen S | 1984 | Delta-9-THC | Controlled study | Poorer antiemetic control and more side effects with dronabinol than with the metoclopramide, both better than placebo | ||||||
| Show | Cancer chemotherapy; Nausea/vomiting | Antiemetics in patients receiving chemotherapy for cancer: a randomized comparison of delta-9-tetrahydrocannabinol and prochlorperazine. | Sallan SE, Cronin C, Zelen M, Zinberg NE | 1980 | Delta-9-THC | Controlled study | no nausea and vomiting in 36 of 79 courses of chemotherapy with THC compared to 16 of 78 courses in patients who received prochlorperazine; improved appetite with THC | ||||||
| Show | Pain | Antinociceptive, subjective and behavioral effects of smoked marijuana in humans. | Greenwald MK, Stitzer ML. | 2000 | Cannabis | Controlled study | Cannabis produced dose-dependent antinociception | ||||||
| Show | Pain | Are oral cannabinoids safe and effective in refractory neuropathic pain? | Attal N, Brasseur L, Guirimand D, Clermond-Gnamien S, Atlami S, Bouhassira D | 2004 | Delta-9-THC | Open study | No significant decraese of pain in 7 patients, more than 60% decrease in one patient | ||||||
| Show | Sleep disorder | Around-the-clock oral THC effects on sleep in male chronic daily cannabis smokers. | Gorelick DA, Goodwin RS, Schwilke E, Schroeder JR, Schwope DM, Kelly DL, Ortemann-Renon C, Bonnet D, Huestis MA. | 2013 | Delta-9-THC | Open study | Higher THC concentrations were significantly associated with less difficulty falling asleep and more daytime sleep the following day. | ||||||
| Show | Association and Clinical Outcomes of Marijuana in Patients with Intracerebral Hemorrhage. | Malhotra K, Rumalla K, Mittal MK. | 2018 | Cannabis | Open study | Cannabis use does not increase the risk of stroke due to bleeding in the brain | |||||||
| Show | Psychosis/schizophrenia | Association between alcohol, cannabis, and other illicit substance abuse and risk of developing schizophrenia: a nationwide population based register study | Nielsen SM, Toftdahl NG, Nordentoft M, Hjorthøj C | 2017 | Cannabis | Open study | Cannabis and alcohol use were associated with increased risk of schizophrenia | ||||||
| Show | Gastrointestinal disorder | Association Between Cannabis Use and Complications Related to Crohn's Disease: A Retrospective Cohort Study. | Mbachi C, et al. | 2019 | Cannabis | Open study | Cannabis may reduce complications of Crohn’s disease | ||||||
| Show | Association between the detection of alcohol, illicit drugs and/or psychotropic medications/opioids in patients admitted due to trauma and trauma recidivism: A cohort study. | Cordovilla-Guardia S, et al. | 2018 | Cannabis | Open study | Alcohol and cannabis use was associated with an increased risk of re-injury | |||||||
| Show | Pain | Association Between US State Medical Cannabis Laws and Opioid Prescribing in the Medicare Part D Population | Bradford AC, Bradford WD, Abraham A, Bagwell Adams G | 2018 | Cannabis | Open study | Legalization of cannabis for medical use is associated with reduced prescriptions of opioids | ||||||
| Show | Appetite loss/weight loss | Association Between Use of Cannabis in Adolescence and Weight Change into Midlife | Jin LZ, Rangan A, Mehlsen J, Andersen LB, Larsen SC4, Heitmann BL | 2017 | Cannabis | Open study | Cannabis use during adolescence not associated with weight in midlife | ||||||
| Show | Anxiety | Association of cannabis use with the development of elevated anxiety symptoms in the general population: a meta-analysis | Twomey CD. | 2017 | Cannabis | No relevant association between cannabis use and anxiety in the general population | |||||||
| Show | Association of Cannabis With Cognitive Functioning in Adolescents and Young Adults: A Systematic Review and Meta-analysis | Scott JC et al. | 2018 | Cannabis | Effects of cannabis on cognitive performance in adolescents are small | ||||||||
| Show | HIV/AIDS | Association of Cannabis, Stimulant, and Alcohol use with Mortality Prognosis Among HIV-Infected Men | Adams, Joëlla W. et al. | 2018 | Cannabis | Survey | Cannabis use has no effect on the mortality of HIV-infected men | ||||||
| Show | Pain | Association of Medical and Adult-Use Marijuana Laws With Opioid Prescribing for Medicaid Enrollees | Wen H, Hockenberry JM | 2018 | Cannabis | Open study | Legalization of cannabis for medical use is associated with reduced prescriptions of opioids | ||||||
| Show | Association of State Recreational Marijuana Laws With Adolescent Marijuana Use | Cerdá M, Wall M, Feng T, Keyes KM, Sarvet A, Schulenberg J, O'Malley PM, Pacula RL, Galea S, Hasin DS | 2017 | Cannabis | Survey | Mixed consequences of cannabis legalization on cannabis use by adolescents | |||||||
| Show | Associations between cannabis use and cardiometabolic risk factors: A longitudinal study of men. | Meier MH, Pardini D, Beardslee J, Matthews KA. | 2018 | Cannabis | Open study | Cannabis use is associated with lower risk for factors associated with diseases of heart and blood vessels | |||||||
| Show | Appetite loss/weight loss | Behavioral analysis of marijuana effects on food intake in humans. | Foltin RW, Fishman MW, Brady JV. | 1986 | Cannabis | Controlled study | The administration of two or three active marijuana cigarettes during the social access period increased average daily caloric intake. | ||||||
| Show | Parkinson's disease | Beneficial and adverse effects of cannabidiol in a Parkinson patient with sinemet-induced dystonic dyskinesia. | Snider SR, Consroe P. | 1985 | Cannabidiol | Uncontrolled case report | Improvement of dyskinesia | ||||||
| Show | Beneficial Effect of Medical Cannabis in the Treatment of a Pharmacoresistant Nausea Associated with a Somatoform Disorder in a Patient with Post-Polio Syndrome | Bleckwenn M, Weckbecker K, Voss S | 2018 | Cannabis | Uncontrolled case report | Cannabis improved nausea in a patient with post-polio syndrome | |||||||
| Show | Brief Report: Cannabidiol-Rich Cannabis in Children with Autism Spectrum Disorder and Severe Behavioral Problems-A Retrospective Feasibility Study. | Aran A, Cassuto H, Lubotzky A, Wattad N, Hazan E. | 2018 | Cannabidiol | Open study | Cannabis may be helpful in the treatment of children with autism in an open study | |||||||
| Show | Asthma | Bronchial effects of aerosolized delta 9-tetrahydrocannabinol in healthy and asthmatic subjects. | Tashkin DP, Reiss S, Shapiro BJ, Calvarese B, Olsen JL, Lodge JW. | 1977 | Delta-9-THC | Controlled study | THC effective in healthy subjects and 3 asthmatic subjects; aerosol caused bronchoconstriction in 2 asthmatic subjects | ||||||
| Show | Asthma | Bronchodilator effect of delta1-tetrahydrocannabinol administered by aerosol of asthmatic patients. | Williams SJ, Hartley JP, Graham JD | 1976 | Delta-9-THC | Controlled study | significant broncholdilation with THC; faster action of salbutamol but both drugs equivalent at 1 hour | ||||||
| Show | Caloric restriction lowers endocannabinoid tonus and improves cardiac function in type 2 diabetes | van Eyk HJ et al. | 2018 | Open study | Caloric restriction in patients with type 2 diabetes reduces endocannabinoid levels | ||||||||
| Show | Psychosis/schizophrenia | Cannabidiol (CBD) as an Adjunctive Therapy in Schizophrenia: A Multicenter Randomized Controlled Trial | McGuire P et al. | 2018 | Cannabidiol | Controlled study | Cannabidiol may be helpful in schizophrenia according to clinical study | ||||||
| Show | Epilepsy | Cannabidiol as a new treatment for drug-resistant epilepsy in tuberous sclerosis complex. | Hess EJ, Moody KA, Geffrey AL, Pollack SF, Skirvin LA, Bruno PL, Paolini JL, Thiele EA. | 2016 | Cannabidiol | Open study | cannabidiol (CBD) was shown to be effective in the treatment of epilepsy due to Tuberous sclerosis complex | ||||||
| Show | Epilepsy | Cannabidiol as a Potential Treatment for Febrile Infection-Related Epilepsy Syndrome (FIRES) in the Acute and Chronic Phases. | Gofshteyn JS, Wilfong A, Devinsky O, Bluvstein J, Charuta J, Ciliberto MA, Laux L, Marsh ED. | 2016 | Cannabidiol | Uncontrolled case report | Cannabidiol is effective in febrile infection-related epilepsy syndrome in a case series | ||||||
| Show | Appetite loss/weight loss | Cannabidiol attenuates the appetitive effects of Delta 9-tetrahydrocannabinol in humans smoking their chosen cannabis. | Morgan CJ, Freeman TP, Schafer GL, Curran HV. | 2010 | Cannabis | Open study | Effects depended on the ratio of CBD and THC with high CBD reducing appetite enhancing effects of THC. | ||||||
| Show | Cannabidiol Based Medical Cannabis in Children with Autism- a Retrospective Feasibility Study | Aran A., Cassuto H., Lubotzky A. | 2018 | Cannabis;Cannabidiol | Open study | A CBD-rich cannabis extract may be effective in children with autism | |||||||
| Show | Psychosis/schizophrenia | Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia | Leweke FM, Piomelli D, Pahlisch F, Muhl D, Gerth CW, Hoyer C, Klosterkötter J, Hellmich M, Koethe D. | 2012 | Cannabidiol | Controlled study | CBD was as effective as amisulpride, a standard antipsychotic | ||||||
| Show | Anxiety;Posttraumatic stress disorder | Cannabidiol enhances consolidation of explicit fear extinction in humans. | Das RK, Kamboj SK, Ramadas M, Yogan K, Gupta V, Redman E, Curran HV, Morgan CJ | 2013 | Cannabidiol | Controlled study | Cannabidiol enhances consolidation of fear extinction in humans. | ||||||
| Show | Dependency/withdrawal | Cannabidiol for the Reduction of Cue-Induced Craving and Anxiety in Drug-Abstinent Individuals With Heroin Use Disorder: A Double-Blind Randomized Placebo-Controlled Trial. | Hurd YL, Spriggs S, Alishayev J, Winkel G, Gurgov K, Kudrich C, Oprescu AM, Salsitz E. | 2019 | Cannabidiol | Controlled study | CBD reduces craving in drug-abstinence individuals with heroin dependency according to clinical study | ||||||
| Show | Dependency/withdrawal | Cannabidiol for the treatment of cannabis withdrawal syndrome: a case report. | Crippa JA, Hallak JE, Machado-de-Sousa JP, Queiroz RH, Bergamaschi M, Chagas MH, Zuardi AW. | 2013 | Cannabidiol | Uncontrolled case report | They were no major withdrawal symptoms. | ||||||
| Show | Epilepsy | Cannabidiol for treating drug-resistant epilepsy in children: the New South Wales experience. | Chen KA, Farrar M, Cardamone M, Gill D, Smith R, Cowell CT, Truong L, Lawson JA. | 2018 | Cannabidiol | Open study | CBD effective in children with epilepsy | ||||||
| Show | Epilepsy | Cannabidiol for treatment of refractory childhood epilepsies: Experience from a single tertiary epilepsy center in Slovenia | 2018 | Cannabidiol | Open study | About half of children with epilepsy had a significant improvement following CBD treatment | |||||||
| Show | Epilepsy | Cannabidiol improves frequency and severity of seizures and reduces adverse events in an open-label add-on prospective study. | Szaflarski JP, Bebin EM, Cutter G, DeWolfe J, Dure LS, Gaston TE, Kankirawatana P, Liu Y, Singh R, Standaert DG, Thomas AE, Ver Hoef LW; UAB CBD Program. | 2018 | Cannabidiol | Open study | Large study with CBD in patients with epilepsy demonstrates good long-term safety of the medication | ||||||
| Show | Anxiety | Cannabidiol in Anxiety and Sleep: A Large Case Series. | Shannon S, Lewis N, Lee H, Hughes S. | 2019 | Cannabidiol | Open study | CBD may be helpful in anxiety disorders according to a case series | ||||||
| Show | Dystonia | Cannabidiol in dystonic movement disorders. | Sandyk R, Snider SR, Consroe P, Elias SM. | 1986 | Cannabidiol | Uncontrolled case report | Cannabidiol (CBD) reduced dystonic movements | ||||||
| Show | Epilepsy | Cannabidiol in patients with Lennox-Gastaut syndrome: Interim analysis of an open-label extension study. | Thiele E, et al. | 2019 | Cannabidiol | CBD showed long-term efficacy in the treatment of epilepsy due to Lenox-Gastaut syndrome | |||||||
| Show | Rare diseases | Cannabidiol in patients with seizures associated with Lennox-Gastaut syndrome (GWPCARE4): a randomised, double-blind, placebo-controlled phase 3 trial | Thiele EA. et al. | 2018 | Cannabidiol | Controlled study | CBD is effective against seizures in Lennox-Gastaut syndrome | ||||||
| Show | Epilepsy | Cannabidiol in patients with treatment-resistant epilepsy: an open-label interventional trial. | Devinsky O, Marsh E, Friedman D, Thiele E, Laux L, Sullivan J, Miller I, Flamini R, Wilfong A, Filloux F, Wong M, Tilton N, Bruno P, Bluvstein J, Hedlund J, Kamens R, Maclean J, Nangia S, Singhal NS, Wilson CA, Patel A, Cilio MR. | 2015 | Cannabidiol | Open study | Cannabidiol reduces seizure frequency in epilepsy of children and young adults | ||||||
| Show | Posttraumatic stress disorder | Cannabidiol in the Treatment of Post-Traumatic Stress Disorder: A Case Series. | Elms L, Shannon S, Hughes S, Lewis N. | 2018 | Cannabidiol | Uncontrolled case report | CBD may be beneficial in the post-traumatic stress disorder according to case series | ||||||
| Show | Cannabidiol monotherapy for treatment-resistant schizophrenia | Zuardi AW, Hallak JE, Dursun SM, Morais SL, Faria Sanches R, Musty RE, Crippa JA. | 2006 | Cannabidiol | Open study | CBD monotherapy was not effective in treatment-resistant schizophrenia | |||||||
| Show | Anxiety | Cannabidiol Reduces the Anxiety Induced by Simulated Public Speaking in Treatment-Naïve Social Phobia Patients. | Bergamaschi MM, Queiroz RH, Chagas MH, de Oliveira DC, De Martinis BS, Kapczinski F, Quevedo J, Roesler R, Schröder N, Nardi AE, Martín-Santos R, Hallak JE, Zuardi AW, Crippa JA. | 2011 | Cannabidiol | Controlled study | Cannabidiol significamtly reduced anxiety. | ||||||
| Show | Dependency/withdrawal | Cannabidiol reverses attentional bias to cigarette cues in a human experimental model of tobacco withdrawal | Hindocha C. et al. | 2018 | Cannabidiol | Controlled study | CBD may be helpful in tobacco dependency | ||||||
| Show | Pain | Cannabinoid agonists attenuate capsaicin-induced responses in human skin. | Rukwied R, Watkinson A, McGlone F, Dvorak M. | 2003 | Other cannabinoids | Controlled study | A topically applied cannabinoid receptor agonist (HU210) reduced pain caused by capsaicin | ||||||
| Show | Cannabinoid concentrations in blood and urine after smoking cannabidiol joints. | Meier U, Dussy F, Scheurer E, Mercer-Chalmers-Bender K, Hangartner S. | 2018 | Cannabidiol | Uncontrolled case report | CBD blood concentrations after smoking CBD cigarettes | |||||||
| Show | Cannabinoid concentrations in confiscated cannabis samples and in whole blood and urine after smoking CBD-rich cannabis as a "tobacco substitute". | Hädener M, Gelmi TJ, Martin-Fabritius M, Weinmann W, Pfäffli M. | 2019 | Cannabidiol | Controlled study | CBD-rich cannabis legally available in Switzerland may cause positive THC tests on blood and urine | |||||||
| Show | Cannabinoid effects on ventilation and breathlessness: A pilot study of efficacy and safety. | Pickering EE, Semple SJ, Nazir MS, Murphy K, Snow TM, Cummin AR, Moosavi S, Guz A, Holdcroft A. | 2011 | Cannabis | Controlled study | With cannabis participants felt less breathless | |||||||
| Show | Multiple sclerosis | Cannabinoid influence on cytokine profile in multiple sclerosis. | Katona S, Kaminski E, Sanders H, Zajicek J. | 2005 | Cannabis;Delta-9-THC | Controlled study | There were no significant effects of cannabinoids on the cytokine profiles examined. | ||||||
| Show | Cancer | Cannabinoid receptor expression in estrogen-dependent and estrogen-independent endometrial cancer. | Ayakannu T, Taylor AH, Konje JC. | 2018 | Other cannabinoids | Open study | Cannabinoid receptors may be therapeutic targets in the treatment or prevention of endometrial cancer | ||||||
| Show | Gastrointestinal disorder | Cannabinoid Use in Patients With Gastroparesis and Related Disorders: Prevalence and Benefit. | Jehangir A, Parkman HP. | 2019 | Cannabis | Survey | Cannabis may be an effective treatment of delayed gastric emptying according to a survey | ||||||
| Show | Multiple sclerosis;Pain | Cannabinoid-induced effects on the nociceptive system: a neurophysiological study in patients with secondary progressive multiple sclerosis. | Conte A, Bettolo CM, Onesti E, Frasca V, Iacovelli E, Gilio F, Giacomelli E, Gabriele M, Aragona M, Tomassini V, Pantano P, Pozzilli C, Inghilleri M. | 2009 | Cannabis | Controlled study | The study provides objective neurophysiological evidence that cannabinoids modulate the nociceptive system. | ||||||
| Show | Pain | Cannabinoid-opioid interaction in chronic pain | Abrams DI, Couey P, Shade SB, Kelly ME, Benowitz NL | 2011 | Cannabis | Open study | Pain was significantly decreased | ||||||
| Show | Pain | Cannabinoids and spinal cord stimulation for the treatment of failed back surgery syndrome refractory pain. | Mondello E, Quattrone D, Cardia L, Bova G, Mallamace R, Barbagallo AA, Mondello C, Mannucci C, Di Pietro M, Arcoraci V, Calapai G. | 2018 | Delta-9-THC;Cannabidiol | Open study | Cannabis improves pain in patients with failed back surgery syndrome | ||||||
| Show | Pain | Cannabinoids as effective as pharmaceutical treatments for migraine attacks | Gary Scattergood | 2017 | Other cannabinoids | Open study | Cannabis effective in migraine and cluster headache in a clinical study | ||||||
| Show | Huntington's disease | Cannabinoids for Treatment of Dystonia in Huntington's Disease | Saft C, von Hein SM, Lücke T, Thiels C, Peball M, Djamshidian A, Heim B3, Seppi K | 2018 | Other cannabinoids | Open study | Cannabinoids may be helpful in the treatment of Huntington's disease | ||||||
| Show | Spasticity;Multiple sclerosis;Pain | Cannabinoids for treatment of spasticity and other symptoms related to multiple sclerosis (CAMS study): multicentre randomised placebo-controlled trial. | Zajicek J, Fox P, Sanders H, Wright D, Vickery J, Nunn A, Thompson A, on behalf of the UK | 2003 | Cannabis;Delta-9-THC | Controlled study | No effect of cannabinoids on spasticity as measured by the Ashworth scale, while patient-reported spasticity and pain decreased. | ||||||
| Show | Tourette's syndrome | Cannabinoids improve driving ability in a Tourette's patient. | Brunnauer A, Segmiller FM, Volkamer T, Laux G, Müller N, Dehning S | 2011 | Delta-9-THC | Uncontrolled case report | THC improved driving ability | ||||||
| Show | Attention-deficit/hyperactivity disorder | Cannabinoids in attention-deficit/hyperactivity disorder: a randomised-controlled trial | Cooper RE, Williams E, Seegobin S, Tye C, Kuntsi J, Asherson P | 2017 | Other cannabinoids | Controlled study | Cannabis reduced symptoms of ADHD in a small clinical study | ||||||
| Show | Attention-deficit/hyperactivity disorder | Cannabinoids in attention-deficit/hyperactivity disorder: a randomised-controlled trial | R.E. Cooper, E. Williams, S. Seegobin, C. Tye, J. Kuntsi, P. Asherson | 2016 | Delta-9-THC;Cannabidiol | Controlled study | Cannabis may be helpful in the treatment of ADHD | ||||||
| Show | Spasticity;Multiple sclerosis | Cannabinoids in multiple sclerosis (CAMS) study: safety and efficacy data for 12 months follow up. | Zajicek JP, Sanders HP, Wright DE, Vickery PJ, Ingram WM, Reilly SM, Nunn AJ, Teare LJ, Fox PJ, Thompson AJ. | 2005 | Cannabis;Delta-9-THC | Controlled study | Spasticity in the Ashworth scale was significantly reduced by an average of 1.82 in the THC group; no significant reduction in the cannabis group | ||||||
| Show | Nausea/vomiting;Cancer chemotherapy;Pain | Cannabinoids in the management of intractable chemotherapy-induced nausea and vomiting and cancer-related pain. | Sutton IR, Daeninck P. | 2006 | Nabilone | Survey;Uncontrolled case report | Significant improvement in one case of intractable neuropathic pain and one case of refractory cinv | ||||||
| Show | Parkinson's disease | Cannabinoids reduce levodopa-induced dyskinesia in Parkinson's disease: a pilot study. | Sieradzan KA, Fox SH, Hill M, Dick JP, Crossman AR, Brotchie JM | 2001 | Nabilone | Controlled study | significant reduction of levodopa-induced dyskinesia | ||||||
| Show | Tourette's syndrome | Cannabinoids: possible role in patho-physiology and therapy of Gilles de la Tourette syndrome. | Muller-Vahl KR, Kolbe H, Schneider U, Emrich HM. | 1998 | Cannabis | Survey | Evidence that marijuana improves tics and behavioural disorders in TS. | ||||||
| Show | Parkinson's disease | Cannabis (medical marijuana) treatment for motor and non-motor symptoms of Parkinson disease: an open-label observational study. | Lotan I, Treves TA, Roditi Y, Djaldetti R. | 2014 | Cannabis | Open study | Analysis of specific motor symptoms revealed significant, also sleep and pain improvement after treatment with cannabis. | ||||||
| Show | Pain | Cannabis analgesia in chronic neuropathic pain is associated with altered brain connectivity. | Weizman L, Dayan L, Brill S, Nahman-Averbuch H, Hendler T, Jacob G, Sharon H. | 2018 | Delta-9-THC | Controlled study | THC reduces neuropathic pain and this is associated with altered connections between two brain regions | ||||||
| Show | Nausea/vomiting;Cancer chemotherapy | Cannabis and cancer chemotherapy: a comparison of oral delta-9-THC and prochlorperazine. | Ungerleider JT, Andrysiak T, Fairbanks L, Goodnight J, Sarna G, Jamison K. | 1982 | Delta-9-THC | Controlled study | No significant differences between THC and prochlorperazine | ||||||
| Show | Multiple sclerosis | Cannabis and cognitive functioning in multiple sclerosis: The role of gender | Patel VP, Feinstein A | 2017 | Cannabis | Open study | Cannabis use may have a negative effect on cognition in male patients with multiple sclerosis | ||||||
| Show | Pain | Cannabis and intractable chronic pain: an explorative retrospective analysis of Italian cohort of 614 patients | Fanelli G et al. | 2017 | Cannabis;Other cannabinoids | Open study | Cannabis may be effective in the treatment of chronic pain according to a large case series from Italy | ||||||
| Show | Epilepsy | Cannabis and other illicit drug use in epilepsy patients. | Hamerle M, Ghaeni L, Kowski A, Weissinger F, Holtkamp M. | 2014 | Cannabis | Survey | The use of cannabis did not affect disease severity in epilepsy. | ||||||
| Show | Dependency/withdrawal | Cannabis as a substitute for alcohol and other drugs | Reiman A. | 2009 | Cannabis | Survey | 40 % use cannabis to substitute for alcohol, 26 % to substitute for illegal drugs | ||||||
| Show | Dependency/withdrawal | Cannabis as a substitute for alcohol and other drugs: A dispensary-based survey of substitution effect in Canadian medical cannabis patients. | Lucas P, Reiman A, Earleywine M, McGowan S, Oleson M, Coward M, Thomas B. | 2013 | Cannabis | Survey | Many patients substitute cannabis for alcohol, illegal and medicinal drugs | ||||||
| Show | Dependency/withdrawal | Cannabis as a Substitute for Alcohol: A Harm-Reduction Approach | Mikuriya TH | 2004 | Cannabis;Nabilone | Uncontrolled case report | Cannabis is a successful substituent of alcohol | ||||||
| Show | Cannabis as a substitute for prescription drugs - a cross-sectional study | Corroon JM Jr, Mischley LK, Sexton M | 2017 | Cannabis | Survey | Cannabis is used as a substitute for prescription drugs according to a large survey | |||||||
| Show | Pain;Spasticity | Cannabis derivatives therapy for a seronegative stiff-person syndrome: a case report. | Vicente-Valor MI, Garcia-Llopis P, Mejia Andujar L, Antonino de la Camara G, García Del Busto N, Lopez Tinoco M, Quintana Vergara B, Peiro Vilaplana C, Dominguez Moran JA, Sánchez Alcaraz A. | 2012 | Cannabis | Uncontrolled case report | The cannabis extract was effective in a patient with stiff person syndrome. | ||||||
| Show | Spasticity;Spinal cord injury | Cannabis effect on spasticity in spinal cord injury. | Malec J, Harvey RF, Cayner JJ. | 1982 | Cannabis | Survey | Decreased spasticity with marijuana use | ||||||
| Show | Parkinson's disease | Cannabis for dyskinesia in Parkinson disease: a randomized double-blind crossover study. | Carroll CB, Bain PG, Teare L, Liu X, Joint C, Wroath C, Parkin SG, Fox P, Wright D, Hobart J, Zajicek JP. | 2004 | Cannabis | Controlled study | Cannabis had no treatment effect on levodopa-induced dyskinesia. | ||||||
| Show | Nausea/vomiting | Cannabis for intractable nausea after bilateral cerebellar stroke. | Adhiyaman V, Arshad S. | 2014 | Cannabis | Uncontrolled case report | A woman with intractable nausea after cerebellar stroke responded well to a treatment with THC. | ||||||
| Show | Cannabis for restless legs syndrome: a report of six patients | Megelin T., Ghorayeb I. | 2017 | Cannabis | Uncontrolled case report | Cannabis may be helpful in restless legs syndrome according to case reports | |||||||
| Show | Cancer | Cannabis Impacts Tumor Response Rate to Nivolumab in Patients with Advanced Malignancies. | Taha T, Meiri D, Talhamy S, Wollner M, Peer A, Bar-Sela G. | 2019 | Cannabis | Open study | Cannabis may have negative effects on cancer therapy if given together with immunotherapy | ||||||
| Show | Cannabis improves night vision: A pilot study of dark adaptometry and scotopic sensitivity in kif smokers of the Rif Mountains of Northern Morocco. | Russo EB, Merzouki A, Molero Mesa J, Frey KA, Bach PJ. | 2004 | Cannabis;Delta-9-THC | Controlled study | Oral THC and smoking of cannabis improved night vision | |||||||
| Show | HIV/AIDS;Pain | Cannabis in painful HIV-associated sensory neuropathy: A randomized placebo-controlled trial. | Abrams DI, Jay CA, Shade SB, Vizoso H, Reda H, Press S, Kelly ME, Rowbotham MC, Petersen KL. | 2007 | Cannabis | Controlled study | Smoked cannabis was well tolerated and effectively relieved chronic neuropathic pain from HIV-associated sensory neuropathy. | ||||||
| Show | Gastrointestinal disorder | Cannabis Oil Use by Adolescents and Young Adults With Inflammatory Bowel Disease. | Hoffenberg EJ, McWilliams S, Mikulich-Gilbertson S, Murphy B, Hoffenberg A, Hopfer CJ. | 2019 | Cannabis | Open study | Many young patients with irritable bowel syndrome use cannabis to treat symptoms | ||||||
| Show | Pain | Cannabis reduces opioid dose in the treatment of chronic non-cancer pain. | Lynch ME, Clark AJ. | 2003 | Cannabis | Uncontrolled case report | Improvement in pain, spasticity, bladder spasm, and sleep. | ||||||
| Show | Dependency/withdrawal | Cannabis substitution. An adjunctive therapeutic tool in the treatment of alcoholism. | Mikuriya TH | 1970 | Cannabis | Uncontrolled case report | Marijuana consumption may help to decrease alcolholic intake. | ||||||
| Show | Cannabis treatments in obstetrics and gynecology: A historical review. | Russo E. | 2002 | Cannabis | Uncontrolled case report | Cannabis was effective in a wide range of gynecological conditions | |||||||
| Show | Gastrointestinal disorder;Inflammation | Cannabis use amongst patients with inflammatory bowel disease. | Lal S, Prasad N, Ryan M, Tangri S, Silverberg MS, Gordon A, Steinhart H. | 2011 | Cannabis | Survey | Cannabis use is frequent in patients with chronic intestinal inflammation | ||||||
| Show | Psychosis/schizophrenia | Cannabis use and psychotic-like experiences trajectories during early adolescence: the coevolution and potential mediators | Bourque J, Afzali MH, O'Leary-Barrett M, Conrod P | 2017 | Cannabis | Open study | Cannabis use in adolescents was associated with psychotic-like experiences | ||||||
| Show | Depression | Cannabis use and the course and outcome of major depressive disorder: A population based longitudinal study. | Feingold D, Rehm J, Lev-Ran S | 2017 | Cannabis | Open study | No association between cannabis use and depression | ||||||
| Show | Cannabis use as a risk factor for causing motor vehicle crashes: a prospective study. | Brubacher JR. et al. | 2019 | Cannabis | Open study | Non-significant increase of crash risk in drivers under the influence of cannabis | |||||||
| Show | Spasticity;Multiple sclerosis;Pain;Depression | Cannabis use as described by people with multiple sclerosis. | Page SA, Verhoef MJ, Stebbins RA, Metz LM, Levy JC. | 2003 | Cannabis | Survey | Improvement of pain, spasticity and anxiety/depression | ||||||
| Show | Anxiety | Cannabis use behaviors and prevalence of anxiety and depressive symptoms in a cohort of Canadian medicinal cannabis users. | Turna J, Simpson W, Patterson B, Lucas P, Van Ameringen M. | 2019 | Cannabis | Survey | Cannabis may be helpful in anxiety disorders according to large survey | ||||||
| Show | Epilepsy | Cannabis Use Disorder and Epilepsy: A Cross-National Analysis of 657 072 Hospitalized Patients | Patel RS, Mekala HM, Tankersley WE. | 2019 | Cannabis | Open study | The use of cannabis, tobacco and alcohol is associated with higher prevalence of epilepsy | ||||||
| Show | Posttraumatic stress disorder | Cannabis Use Disorder and Post-Deployment Suicide Attempts in Iraq/Afghanistan-Era Veterans | Adkisson K, Cunningham KC, Dedert EA, Dennis MF, Calhoun PS, Elbogen EB, Beckham JC, Kimbrel NA. | 2018 | Cannabis | Survey | Cannabis dependence was associated with an increased risk of suicide in war veterans | ||||||
| Show | Gastrointestinal disorder;Psychosis/schizophrenia | Cannabis use disorders may protect against certain disorders of the digestive organs in people with schizophrenia but not in healthy controls. | Olesen JA, Posselt CM, Poulsen CH, Nordentoft M, Hjorthøj C. | 2019 | Cannabis | Survey | Cannabis use in patients with schizophrenia is associated with a reduced risk for inflammatory bowel disease | ||||||
| Show | Pain | Cannabis use for chronic non-cancer pain: results of a prospective survey. | Ware MA, Doyle CR, Woods R, Lynch ME, Clark AJ | 2003 | Cannabis | Survey | Cannabis use is prevalent among the chronic non-cancer pain population | ||||||
| Show | Nausea/vomiting | Cannabis use improves retention and virological outcomes in patients treated for hepatitis C. | Sylvestre DL, Clements BJ, Malibu Y. | 2006 | Cannabis | Open study | Participants who used cannabis maintained adherence to treatment more offen | ||||||
| Show | Nausea/vomiting;Appetite loss/weight loss;HIV/AIDS;Pain;Anxiety | Cannabis use in HIV for pain and other medical symptoms. | Woolridge E, Barton S, Samuel J, Osorio J, Dougherty A, Holdcroft A. | 2005 | Cannabis | Survey | 27% used cannabis for the treatment of various symptoms | ||||||
| Show | Spinal cord injury | Cannabis Use in Individuals With Spinal Cord Injury or Moderate to Severe Traumatic Brain Injury in Colorado | Hawley LA, Ketchum JM, Morey C, Collins K, Charlifue S | 2018 | Cannabis | Survey | A high number of patients with spinal cord injury and traumatic brain injury use cannabis | ||||||
| Show | Pain | Cannabis use in patients with fibromyalgia: effect on symptoms relief and health-related quality of life. | Fiz J, Durán M, Capellà D, Carbonell J, Farré M. | 2011 | Cannabis | Open study | The use of cannabis was associated with reduction of some fibromyalgia symptoms. | ||||||
| Show | Spasticity;Multiple sclerosis;Pain | Cannabis use in patients with multiple sclerosis. | Chong MS, Wolff K, Wise K, Tanton C, Winstock A, Silber E. | 2006 | Cannabis | Survey | A subgroup of patients with severe disabilitiy appears to derive some benefit | ||||||
| Show | Parkinson's disease | Cannabis use in people with Parkinson's disease and Multiple Sclerosis: A web-based investigation | Kindred JH, Li K, Ketelhut NB, Proessl F, Fling BW, Honce JM, Shaffer WR, Rudroff T | 2017 | Cannabis | Survey | Cannabis may be helpful in Parkinson’s disease according to a survey | ||||||
| Show | Spinal cord injury | Cannabis use in persons with traumatic spinal cord injury in Denmark | Andresen SR, Biering-Sørensen F, Hagen EM, Nielsen JF, Bach FW, Finnerup NB | 2017 | Cannabis | Survey | Cannabis use is more frequent among people with spinal cord injury than among the general population | ||||||
| Show | Pain;Depression;Anxiety | Cannabis use in sickle cell disease: a questionnaire study. | Howard J, Anie KA, Holdcroft A, Korn S, Davies SC. | 2005 | Cannabis | Survey | 36% had used cannabis to treat symptoms | ||||||
| Show | HIV/AIDS;Pain | Cannabis Use is Associated with Lower Odds of Prescription Opioid Analgesic Use Among HIV-Infected Individuals with Chronic Pain | Sohler NL, Starrels JL, Khalid L, Bachhuber MA, Arnsten JH, Nahvi S, Jost J, Cunningham CO | 2018 | Cannabis | Open study | Medical cannabis legislation might reduce the need for opioid analgesics for pain management | ||||||
| Show | Cannabis use is associated with reduced prevalence of non-alcoholic fatty liver disease: A cross-sectional study. | Adejumo AC et al. | 2017 | Cannabis | Survey | Cannabis use is associated with a lower prevalence of non-alcoholic fatty liver disease according to a large study | |||||||
| Show | Cannabis use is associated with reduced prevalence of progressive stages of alcoholic liver disease. | Adejumo AC, Ajayi TO, Adegbala OM, Adejumo KL, Alliu S, Akinjero AM, Onyeakusi NE, Ojelabi O, Bukong TN | 2018 | Cannabis | Open study | Cannabis use may be associated with a reduced incidence of liver disease in alcoholics | |||||||
| Show | Cannabis use patterns and motives: A comparison of younger, middle-aged, and older medical cannabis dispensary patients. | Haug NA, Padula CB, Sottile JE, Vandrey R, Heinz AJ, Bonn-Miller MO | 2017 | Cannabis | Survey | : Low age associated with higher problematic cannabis use among medical cannabis users | |||||||
| Show | Cannabis, Tobacco, Alcohol Use, and the Risk of Early Stroke: A Population-Based Cohort Study of 45 000 Swedish Men | Falkstedt D, Wolff V, Allebeck P, Hemmingsson T, Danielsson AK | 2017 | Cannabis | Open study | Cannabis use does not increase the risk of stroke in young people, while tobacco does | |||||||
| Show | Spasticity;Multiple sclerosis | Cannabis-based medicinal extract (Sativex) produced significant improvements in a subjective measure of spasticity which were maintained on long-term treatment with no evidence of tolerance. | Robson P, Wade D, Makela P, House H, Bateman C | 2005 | Cannabis | Controlled study | Beneficial effects of cannabis on spasticity in MS seem to be maintained over long-term treatment, with no evidence of tolerance. | ||||||
| Show | Multiple sclerosis | Cannabis; adverse effects from an oromucosal spray. | Scully C. | 2007 | Cannabis | Open study | The spray caused reversible damage to the mucosa | ||||||
| Show | Cancer | Case Report: Clinical Outcome and Image Response of Two Patients With Secondary High-Grade Glioma Treated With Chemoradiation, PCV, and Cannabidiol. | Dall'Stella PB, Docema MFL, Maldaun MVC, Feher O, Lancellotti CLP. | 2019 | Cannabidiol | Uncontrolled case report | CBD may increase the effects of chemotherapy and radiation in glioblastoma according to case reports | ||||||
| Show | Epilepsy | CBD-enriched medical cannabis for intractable pediatric epilepsy: The current Israeli experience. | Tzadok M, Uliel-Siboni S, Linder I, Kramer U, Epstein O, Menascu S, Nissenkorn A, Yosef OB, Hyman E, Granot D, Dor M, Lerman-Sagie T, Ben-Zeev B. | 2016 | Cannabidiol | Controlled study | Improvement in behaviour and alertness, language, communication, motor skills and sleep | ||||||
| Show | Pain | Characteristics of patients with chronic pain accessing treatment with medical cannabis in Washington State. | Aggarwal SK, Carter GT, Sullivan MD, ZumBrunnen C, Morrill R, Mayer JD. | 2009 | Cannabis | Open study | 88 % suffer from more than one pain syndrome | ||||||
| Show | Childhood academic ability in relation to cigarette, alcohol and cannabis use from adolescence into early adulthood: Longitudinal Study of Young People in England (LSYPE). | Williams J, Hagger-Johnson G | 2017 | Cannabis | Survey | High academic ability reduced the risk of tobacco smoking but increased the risk of cannabis use in adolescents | |||||||
| Show | Epilepsy | Chronic administration of cannabidiol to healthy volunteers and epileptic patients. | Cunha JM, Carlini EA, Pereira AE, Ramos OL, Pimentel C, Gagliardi R, Sanvito WL, Lander N, Mechoulam R | 1980 | Cannabidiol | Controlled study | 4 of the 8 CBD subjects remained almost free of convulsive crises and 3 other patients demonstrated partial improvement | ||||||
| Show | Epilepsy | Chronic administration of cannabidiol to healthy volunteers and epileptic patients. | Cunha JM, Carlini EA, Pereira AE, Ramos OL, Pimentel C, Gagliardi R, Sanvito WL, Lander N, Mechoulam R | 1980 | Cannabidiol | Controlled study | 4 of the 8 CBD subjects remained almost free of convulsive crises and 3 other patients demonstrated partial improvement | ||||||
| Show | Chronic Cannabis Use in the Compassionate Investigational New Drug Program: An Examination of Benefits and Adverse Effects of Legal Clinical Cannabis | E. Russo, M.L. Mathre, A. Byrne, R. Velin, P.J. Bach, J. Sanchez-Ramos, K.A. Kirlin | 2002 | Cannabis | Uncontrolled case report | Effective treatment of different serious conditions with cannabis | |||||||
| Show | Pain | Chronic pain patients' perspectives of medical cannabis | Piper BJ, Beals ML, Abess AT, Nichols SD, Martin M, Cobb CM, DeKeuster RM. | 2017 | Cannabis | Survey | Medical cannabis patients rate cannabis as very effective | ||||||
| Show | Pain | Chronic Pain Treatment With Cannabidiol in Kidney Transplant Patients in Uruguay | Cuñetti L, Manzo L, Peyraube R, Arnaiz J, Curi L, Orihuela S | 2018 | Cannabidiol | Open study | CBD may reduce pain in patients with kidney transplants | ||||||
| Show | Circulating Endocannabinoids Are Reduced Following Bariatric Surgery and Associated with Improved Metabolic Homeostasis in Humans | Azar S. et al. | 2018 | Other cannabinoids | Endocannabinoid levels in obese patients were reduced after surgery against obesity | ||||||||
| Show | Multiple sclerosis;Spasticity | Clinical experience with THC:CBD oromucosal spray in patients with multiple sclerosis-related spasticity. | Koehler J, Feneberg W, Meier M, Pöllmann W. | 2014 | Cannabis | Open study | The mean spasticity decreased by 57%. | ||||||
| Show | Multiple sclerosis;Spasticity | Clinical experiences with cannabinoids in spasticity management in multiple sclerosis. | Lorente Fernández L, Monte Boquet E, Pérez-Miralles F, Gil Gómez I, Escutia Roig M, Boscá Blasco I, Poveda Andrés JL, Casanova-Estruch B. | 2014 | Cannabis | Open study | The cannabis extract was effective in 80% of patients. | ||||||
| Show | Clinical improvement and reduction of immunosuppressive drug therapy in cannabis treated patients with crohn's disease. | Hergenrather JY, Mikuriya TH, Bearman D. | 2005 | Cannabis | Survey | The majority of patients found a substantial improvement of their symptoms | |||||||
| Show | Spinal cord injury | Clinical investigation of delta-9-tetrahydrocannabinol (THC) as an alternative therapy for overactive bladders in spinal cord injury (SCI) patients. | Hagenbach U, Ghafoor N, Brenneisen R, Luz S, Mäder M. | 2001 | Delta-9-THC | Controlled study | Significant improvement of some parameters of bladder function | ||||||
| Show | Glaucoma | Clinical relevance of cannabis tolerance and dependence. | Jones RT, Benowitz NL, Herning RI. | 1981 | Delta-9-THC | Controlled study | |||||||
| Show | Headache/migraine | Cluster attacks responsive to recreational cannabis and dronabinol. | Robbins MS, Tarshish S, Solomon S, Grosberg BM. | 2009 | Cannabis;Delta-9-THC | Uncontrolled case report | Cannabis and THC aborted attacks of headaches. | ||||||
| Show | Amyotrophic lateral sclerosis | Co-medication with Cannabidiol May Slow Down the Progression of Motor Neuron Disease: A Case Report | Nahler G. | 2017 | Cannabidiol | Uncontrolled case report | Cannabidiol slowed progression of amyotrophic lateral sclerosis in a case report | ||||||
| Show | Pain | Combined THC and CBD to treat pain in epidermolysis bullosa: a report of three cases. | Schräder NHB, Duipmans JC, Molenbuur B, Wolff A, Jonkman MF. | 2018 | Delta-9-THC;Cannabidiol | Uncontrolled case report | Cannabis effective against pain due to epidermolysis bullosa according to case reports | ||||||
| Show | Nausea/vomiting;Cancer;Cancer chemotherapy | Comparative trial of the antiemetic effects of THC and haloperidol | Neidhart JA, Gagen MM, Wilson HE, Young DC | 1981 | Delta-9-THC | Controlled study | THC and haloperidol equally effective | ||||||
| Show | Pain | Comparison of analgesic effects and patient tolerability of nabilone and dihydrocodeine for chronic neuropathic pain: randomised, crossover, double blind study. | Frank B, Serpell MG, Hughes J, Matthews JN, Kapur D. | 2008 | Nabilone | Controlled study | Nabilone as effective as hydrocodeine in treating neuropatic pain | ||||||
| Show | Asthma | Comparison of bronchial effects of nabilone and terbutaline in healthy and asthmatic subjects. | Gong H Jr, Tashkin DP, Calvarese B | 1983 | Nabilone | Controlled study | moderate bronchodilator action in healthy subjects; no difference to placebo in asthmatics | ||||||
| Show | Appetite loss/weight loss;Cancer | Comparison of orally administered cannabis extract and delta-9-tetrahydrocannabinol in treating patients with cancer-related anorexia-cachexia syndrome: a multicenter, phase III, randomized, double-blind, placebo-controlled clinical trial from the Cannabis-in-Cachexia-Study-Group | Strasser F, Luftner D, Possinger K, Ernst G, Ruhstaller T, Meissner W, Ko YD, Schnelle M, Reif M, Cerny T. | 2006 | Cannabis;Delta-9-THC | Controlled study | No difference between cannabis, THC and placebo | ||||||
| Show | Pain | Comparison of the analgesic effects of dronabinol and smoked marijuana in daily marijuana smokers. | Cooper ZD, Comer SD, Haney M. | 2013 | Cannabis;Delta-9-THC | Controlled study | THC (dronabinol) and smoked cannabis (marijuana) caused similar effects on pain sensitivity and pain tolerance. | ||||||
| Show | Epilepsy | Composition and Use of Cannabis Extracts for Childhood Epilepsy in the Australian Community | Suraev A. et al. | 2018 | Cannabis | Survey | THC and CBD content in products used for self-treatment of Australian children with epilepsy varies considerably | ||||||
| Show | Dependency/withdrawal | Concurrent cannabis use during treatment for comorbid ADHD and cocaine dependence: effects on outcome. | Aharonovich E, Garawi F, Bisaga A, Brooks D, Raby WN, Rubin E, Nunes EV, Levin FR. | 2006 | Cannabis | Open study | Moderate cannabis use had a positive effect of retention rates and abstinence from cocaine | ||||||
| Show | HIV/AIDS | Confirmed marijuana use and lymphocyte count in black people living with HIV | Keen L 2nd, Abbate A, Blanden G, Priddie C, Moeller FG, Rathore M | 2017 | Cannabis | Open study | Cannabis has no negative effect on the immune system in patients with HIV | ||||||
| Show | Controlled clincal trial of cannabidiol in Huntington's disease. | Consroe P, Laguna J, Allender J, Snider S, Stern L, Sandyk R, Kennedy K, Schram K | 1991 | Cannabidiol | Controlled study | CBD was neither symptomatically effective nor toxic. | |||||||
| Show | Cortical surface morphology in long-term cannabis users: A multi-site MRI study. | Chye Y. et al. | 2018 | Cannabis | Open study | Cannabis use not associated with structure of the brain’s cortex | |||||||
| Show | Dependency/withdrawal | Crack heads and roots daughters: The therapeutic use of cannabis in Jamaica. | Dreher M. | 2002 | Cannabis | Open study | Cannabis was the most effective and readily available therapy to quit cocaine use | ||||||
| Show | Nausea/vomiting;Cancer;Cancer chemotherapy | Crossover comparison of the antiemetic efficacy of nabilone and alizapride in patients with nonseminomatous testicular cancer receiving cisplatin therapy. | Niederle N, Schutte J, Schmidt CG. | 1986 | Nabilone | Controlled study | Nabilone superior to alizapride. | ||||||
| Show | Cumulative Lifetime Marijuana Use and Incident Cardiovascular Disease in Middle Age: The Coronary Artery Risk Development in Young Adults (CARDIA) Study. | Reis JP, et al. | 2017 | Cannabis | Open study | Cannabis use not associated with higher risk of cardiovascular diseases | |||||||
| Show | Cancer | Current natural therapies in the treatment against glioblastoma. | Erices JI, Torres Á, Niechi I, Bernales I, Quezada C. | 2018 | Cannabis | Cannabinoids may be helpful in glioblastoma | |||||||
| Show | Multiple sclerosis;Dystonia | Current status of cannabis treatment of multiple sclerosis with an illustrative case presentation of a patient with MS, complex vocal tics, paroxysmal dystonia, and marijuana dependence treated with dronabinol. | Deutsch SI, Rosse RB, Connor JM, Burket JA, Murphy ME, Fox FJ. | 2008 | Delta-9-THC | Open study | Significant improvement of symptoms | ||||||
| Show | HIV/AIDS | Daily cannabis and reduced risk of steatosis in human immunodeficiency virus and hepatitis C virus-co-infected patients | Nordmann S et al. | 2018 | Cannabis | Open study | Daily cannabis use may protect the liver in people with HIV and hepatitis C | ||||||
| Show | Decreased Cannabinoid CB1 Receptors in Male Tobacco Smokers Examined With Positron Emission Tomography. | Hirvonen J, et al. | 2018 | Open study | Tobacco smokers have reduced concentrations of brain CB1 receptors | ||||||||
| Show | Tourette's syndrome | Delta 9-tetrahydrocannabinol (THC) is effective in the treatment of tics in Tourette syndrome: a 6-week randomized trial. | Muller-Vahl KR, Schneider U, Prevedel H, Theloe K, Kolbe H, Daldrup T, Emrich HM. | 2003 | Delta-9-THC | Controlled study | Results provide evidence that THC is effective in the treatment of tics. | ||||||
| Show | Nausea/vomiting;Cancer;Cancer chemotherapy | Delta-9-tetrahydrocannabinol (THC) as an antiemetic in patients treated with cancer chemotherapy; a double-blind cross-over trial against placebo | Kluin-Nelemans JC, Nelemans FA, Meuwissen OJATh, Maes RAA | 1979 | Delta-9-THC | Controlled study | dronabinol superior to placebo (P<.01 for difference between groups at days 1 and 8 independently) | ||||||
| Show | Nausea/vomiting;Cancer;Cancer chemotherapy | Delta-9-tetrahydrocannabinol as an antiemetic for patients receiving cancer chemotherapy. A comparison with prochlorperazine and a placebo. | Frytak S, Moertel CG, O'Fallon JR, Rubin J, Creagan ET, O'Connell MJ, Schutt AJ, Schwartau NW | 1979 | Delta-9-THC | Controlled study | THC and PCP equally effective; both better than placebo; THC produced psychic effects in 82% | ||||||
| Show | Nausea/vomiting;Cancer;Cancer chemotherapy | Delta-9-tetrahydrocannabinol as an antiemetic in cancer patients receiving high-dose methotrexate. A prospective, randomized evaluation. | Chang AE, Shiling DJ, Stillman RC, Goldberg NH, Seipp CA, Barofsky I, Simon RM, Rosenberg SA. | 1979 | Delta-9-THC | Controlled study | 14 of 15 patients had decreased vomiting and nausea | ||||||
| Show | Delta-9-tetrahydrocannabinol effects in schizophrenia: implications for cognition, psychosis, and addiction. | D'Souza DC, Abi-Saab WM, Madonick S, Forselius-Bielen K, Doersch A, Braley G, Gueorguieva R, Cooper TB, Krystal JH. | 2005 | Delta-9-THC | Controlled study | THC is associated with transient exacerbation in core psychotic and cognitive deficits in schizophrenia. | |||||||
| Show | Alzheimer's disease | Delta-9-tetrahydrocannabinol for night-time agitation in severe dementia | Walther S, Mahlberg R, Eichmann U, Kunz D | 2006 | Delta-9-THC | Open study | Reduction in night-time agitation in actigraphy and in the neuropsychiatric inventory NPI | ||||||
| Show | Appetite loss/weight loss;Cancer | Delta-9-tetrahydrocannabinol may palliate altered chemosensory perception in cancer patients: results of a randomized, double-blind, placebo-controlled pilot trial. | Brisbois TD, de Kock IH, Watanabe SM, Mirhosseini M, Lamoureux DC, Chasen M, Macdonald N, Baracos VE, Wismer WV. | 2011 | Delta-9-THC | Controlled study | THC improved taste and appetite | ||||||
| Show | Spasticity;Spinal cord injury;Pain | Delta-9-tetrahydrocannabinol shows antispastic and analgesic effects in a single case double-blind trial. | Maurer M, Henn V, Dittrich A, Hofmann A | 1990 | Delta-9-THC | Controlled study | THC and codeine reduced pain; THC reduced spasticity | ||||||
| Show | Spinal cord injury | Delta-9-tetrahydrocannabinol-cannabidiol in the treatment of spasticity in chronic spinal cord injury: a clinical experience | Grao-Castellote C, Torralba-Collados F, Gonzalez LM, Giner-Pascual M | 2017 | Other cannabinoids | Open study | Cannabis may be helpful in patients with spinal cord injuries according to an observational study | ||||||
| Show | Pain | Delta-9-THC based monotherapy in fibromyalgia patients on experimentally induced pain, axon reflex flare, and pain relief. | Schley M, Legler A, Skopp G, Schmelz M, Konrad C, Rukwied R. | 2006 | Delta-9-THC | Open study | Five of the nine patients withdrew from the study due to side effects. Four patients experienced significant pain relief | ||||||
| Show | Multiple sclerosis; Spasticity | Delta-9-THC in the treatment of spasticity associated with multiple sclerosis. | Ungerleider JT, Andyrsiak T, Fairbanks L, Ellison GW, Myers LW | 1987 | Delta-9-THC | Controlled study | significant subjective improvement in spasticity at doses of 7.5 mg and above; no objective improvement | ||||||
| Show | Depression | Depression and anxiety among chronic pain patients receiving prescription opioids and medical marijuana | Feingold D, Brill S, Goor-Aryeh I, Delayahu Y, Lev-Ran S | 2017 | Cannabis | Open study | Depression is higher in pain patients receiving opioids compared to those receiving cannabis | ||||||
| Show | Depression | Depression and marijuana use disorder symptoms among current marijuana users | Dierker L, Selya A, Lanza S, Li R3, Rose J | 2018 | Cannabis | Survey | People with depression more often use cannabis | ||||||
| Show | HIV/AIDS | Differential Effects of Medical Marijuana Based on Strain and Route of Administration: A Three-Year Observational Study | Corral VL | 2001 | Cannabis | Uncontrolled case report | |||||||
| Show | Disentangling longitudinal relations between youth cannabis use, peer cannabis use, and conduct problems: developmental cascading links to cannabis use disorder. | Defoe IN, Khurana A, Betancourt LM, Hurt H4, Romer D. | 2018 | Cannabis | Open study | Cannabis use does not increase conduct problems in young people | |||||||
| Show | Spasticity;Multiple sclerosis;Pain;Tremor | Do cannabis-based medicinal extracts have general or specific effects on symptoms in multiple sclerosis? A double-blind, randomized, placebo-controlled study on 160 patients. | Wade DT, Makela P, Robson P, House H, Bateman C. | 2004 | Cannabis | Controlled study | Spasticity scores were significantly reduced by cannabis. | ||||||
| Show | Depression | Does morning affect contribute to daily Cannabis use? | Testa M, Wang W, Derrick JL, Brown WC, Collins RL. | 2019 | Cannabis | Open study | Cannabis use increases positive affect and reduces anxiety | ||||||
| Show | Multiple sclerosis;Pain | Does the cannabinoid dronabinol reduce central pain in multiple sclerosis? Randomised double blind placebo controlled crossover trial | Svendsen KB, Jensen TS, Bach FW | 2004 | Delta-9-THC | Controlled study | Significant reduction of pain by THC | ||||||
| Show | Cancer chemotherapy | Dose ranging evaluation of the antiemetic efficacy and toxicity of intramuscular levonantradol in cancer subjects with chemotherapy-induced emesis. | Stambaugh JE Jr, McAdams J, Vreeland F. | 1984 | Other cannabinoids | Controlled study | Levonantradol more effective than placebo | ||||||
| Show | Nausea/vomiting;Cancer;Cancer chemotherapy | Dose vs response of tetrahydroannabinol (THC) vs prochlorperazine as chemotherapy antiemetics. | Levitt M, Wilson A, Bowman D, Faiman C, Kemel S, Krepart G | 1981 | Delta-9-THC | Controlled study | THC 15 mg was the most effective against vomiting, prochlorperazine was the most effective antinauseant | ||||||
| Show | Pain | Dose-dependent effects of smoked cannabis on capsaicin-induced pain and hyperalgesia in healthy volunteers. | Wallace M, Schulteis G, Atkinson JH, Wolfson T, Lazzaretto D, Bentley H, Gouaux B, Abramson I. | 2007 | Cannabis | Controlled study | A medium dose of cannabis reduced pain, while a high dose increased pain induced by capsaicin | ||||||
| Show | Cancer;Cancer chemotherapy | Double-blind comparison of the antiemetic effects of nabilone and prochlorperazine on chemotherapy-induced emesis. | Steele N, Gralla RJ, Braun DW Jr, Young CW. | 1980 | Nabilone | Controlled study | Both nabilone and prochlorperazine produced antiemetic effects | ||||||
| Show | Dramatic improvement of refractory Isaacs' syndrome after treatment with dronabinol. | Meyniel C, Ollivier Y, Hamidou M, Péréon Y, Derkinderen P. | 2010 | Delta-9-THC | Uncontrolled case report | Dramathic improvement of symptoms (profuse sweating, muscular twitching, weight loss) | |||||||
| Show | Appetite loss/weight loss | Dronabinol - eine mögliche neue Therapieoption bei COPD-Patienten mit pulmonaler Kachexie [Dronabinol, a possible new therapeutic option in patients with COPD and pulmonal cachexia] | Bergmann K-C | 2005 | Delta-9-THC | Open study | On average 1,5 kg of weight gain and increase of walking distance | ||||||
| Show | Appetite loss/weight loss;HIV/AIDS;Alzheimer's disease | Dronabinol and marijuana in HIV(+) marijuana smokers: acute effects on caloric intake and mood. | Haney M, Rabkin J, Gunderson E, Foltin RW. | 2005 | Cannabis;Delta-9-THC | Controlled study | THC and cannabis cause increased caloric intake | ||||||
| Show | Appetite loss/weight loss;HIV/AIDS | Dronabinol and marijuana in HIV-positive marijuana smokers: caloric intake, mood, and sleep. | Haney M, Gunderson EW, Rabkin J, Hart CL, Vosburg SK, Comer SD, Foltin RW | 2007 | Cannabis;Delta-9-THC | Controlled study | THC and cannabis caused an increase in caloric intake and weight | ||||||
| Show | Nausea/vomiting;Cancer;Cancer chemotherapy | Dronabinol and prochlorperazine in combination for treatment of cancer chemotherapy-induced nausea and vomiting. | Lane M, Vogel CL, Ferguson J, Krasnow S, Saiers JL, Hamm J | 1991 | Delta-9-THC | Controlled study | prochlorperazine better than THC, both drugs combined better than both alone | ||||||
| Show | Glaucoma | Dronabinol and retinal hemodynamics in humans. | Plange N, Arend KO, Kaup M, Doehmen B, Adams H, Hendricks S, Cordes A, Huth J, Sponsel WE, Remky A. | 2007 | Delta-9-THC | Open study | THC reduced intraoculat pressure and improved blood circulation in the retina. | ||||||
| Show | Appetite loss/weight loss;HIV/AIDS;Depression | Dronabinol as a treatment for anorexia associated with weight loss in patients with AIDS. | Beal JE, Olson R, Laubenstein L, Morales JO, Bellman P, Yangco B, Lefkowitz L, Plasse TF, Shepard KV | 1995 | Delta-9-THC | Controlled study | increased appetite; improvement in mood; stabel weight | ||||||
| Show | Appetite loss/weight loss;HIV/AIDS | Dronabinol effects on weight in patients with HIV infection. | Gorter R, Seefried M, Volberding P | 1992 | Delta-9-THC | Open study | weight gain | ||||||
| Show | Appetite loss/weight loss;Cancer | Dronabinol enhancement of appetite in cancer patients. | Wadleigh R, Spaulding GM, Lumbersky B, Zimmer M, Shepard K, Plasse T | 1990 | Delta-9-THC | Open study | Patients continued to loose, but the weight loss decreased in all groups; appetite and mood increased | ||||||
| Show | Appetite loss/weight loss;Cancer | Dronabinol enhancement of appetite in cancer patients. | Wadleigh R, Spaulding GM, Lumbersky B, Zimmer M, Shepard K, Plasse T. | 1990 | Delta-9-THC | Open study | Dronabinol stimulated mood and appetite | ||||||
| Show | Alzheimer's disease | Dronabinol for the treatment of agitation and aggressive behavior in acutely hospitalized severely demented patients with noncognitive behavioral symptoms. | Woodward MR, Harper DG, Stolyar A, Forester BP, Ellison JM. | 2014 | Delta-9-THC | Open study | A treatment with oral THC was associated with significant decreases in agitation, as well as improvements in sleep duration and appetite. | ||||||
| Show | Dependency/withdrawal | Dronabinol for the treatment of cannabis dependence: a randomized, double-blind, placebo-controlled trial. | Levin FR, Mariani JJ, Brooks DJ, Pavlicova M, Cheng W, Nunes EV | 2011 | Delta-9-THC | Controlled study | THC caused significant improvement in treatment retention and withdrawal symptoms. | ||||||
| Show | Cancer | Dronabinol for the Treatment of Paraneoplastic Night Sweats in Cancer Patients: A Report of Five Cases. | Carr C, Vertelney H, Fronk J, Trieu S. | 2019 | Delta-9-THC | Uncontrolled case report | THC may reduce night sweats in cancer patients | ||||||
| Show | Pain | Dronabinol increases pain threshold in patients with functional chest pain: a pilot double-blind placebo-controlled trial. | Malik Z, Bayman L, Valestin J, Rizivi-Toner A, Hashmi S, Schey R. | 2016 | Delta-9-THC | Controlled study | THC reduced pain intensity and odynophagia (painful swallowing, in the mouth or oesophagus). | ||||||
| Show | Multiple sclerosis;Pain | Dronabinol Is a Safe Long-Term Treatment Option for Neuropathic Pain Patients | Schimrigk S et al. | 2017 | Other cannabinoids | Open study | No significant difference between placebo and THC in the treatment of pain of patients with multiple sclerosis | ||||||
| Show | Dronabinol reduces signs and symptoms of idiopathic intracranial hypertension: a case report. | Raby WN, Modica PA, Wolintz RJ, Murtaugh K. | 2006 | Cannabis;Delta-9-THC | Uncontrolled case report | Improvement of signs and symptoms of the disease | |||||||
| Show | HIV/AIDS; Appetite loss/weight loss; Depression | Dronabinol stimulates appetite and causes weight gain in HIV patients. | Plasse T, Conant M, Gorter R, Shepard KV | 1992 | Delta-9-THC | Controlled study | increase in appetite, trend toward weight gain | ||||||
| Show | Cancer;Nausea/vomiting | Dronabinol Treatment of Refractory Nausea and Vomiting Related to Peritoneal Carcinomatosis. | Hernandez SL, Sheyner I, Stover KT, Stewart JT. | 2015 | Delta-9-THC | Open study | THC may be very effective in the treatment of nausea and vomiting in end-stage cancer. | ||||||
| Show | Appetite loss/weight loss;Cancer | Dronabinol versus megestrol acetate versus combination therapy for cancer-associated anorexia: a North Central Cancer Treatment Group study. | Jatoi A, Windschitl HE, Loprinzi CL, Sloan JA, Dakhil SR, Mailliard JA, Pundaleeka S, Kardinal CG, Fitch TR, Krook JE, Novotny PJ, Christensen B. | 2002 | Delta-9-THC | Controlled study | megestrol acetate was superior to THC | ||||||
| Show | Obsessive compulsive disorder | Dronabinol, a cannabinoid agonist, reduces hair pulling in trichotillomania: a pilot study. | Grant JE, Odlaug BL, Chamberlain SR, Kim SW. | 2011 | Delta-9-THC | Open study | Statistically significant reduction in symptom severity. | ||||||
| Show | Dependency/withdrawal | DSM-5 cannabis withdrawal syndrome: Demographic and clinical correlates in U.S. adults | Livne O., Shmulewitz D., Lev-Ran S., Hasin D. | 2018 | Cannabis | Survey | Cannabis withdrawal syndrome is found in 12% of frequent users | ||||||
| Show | Traumatic brain injury | Early Survival of Comatose Patients after Severe Traumatic Brain Injury with the Dual Cannabinoid CB1/CB2 Receptor Agonist KN38-7271: A Randomized, Double-Blind, Placebo-Controlled Phase II Trial. | Firsching R, Piek J, Skalej M, Rohde V, Schmidt U, Striggow F; the KN38-7271 Study Group. | 2012 | Other cannabinoids | Controlled study | Survival rates within 1 month of the injury were significantly better. | ||||||
| Show | Effect of a cannabinoid agonist on gastrointestinal transit and postprandial satiation in healthy human subjects: a randomized, placebo-controlled study. | Esfandyari T, Camilleri M, Ferber I, Burton D, Baxter K, Zinsmeister AR. | 2006 | Delta-9-THC | Controlled study | THC retarded gastric emptying | |||||||
| Show | Cancer;Pain | Effect of a nitrogen analog of tetrahydrocannabinol on cancer pain. | Staquet M, Gantt C, Machin D. | 1978 | Other cannabinoids | Controlled study | NIB was superior to placebo and to secobarbital but is not useful clinically because of the frequency of side effects. | ||||||
| Show | Pain | Effect of adding medical cannabis to analgesic treatment in patients with low back pain related to fibromyalgia: an observational cross-over single centre study. | Yassin M, Oron A, Robinson D. | 2018 | Cannabis | Open study | Cannabis may be beneficial in patients with fibromyalgia and low back pain | ||||||
| Show | Pain | Effect of benzopyranoperidine, a delta-9-THC congener, on pain. | Jochimsen PR, Lawton RL, VerSteeg K, Noyes Jr R | 1978 | Other cannabinoids | Controlled study | Bezopyranoperidine was not more effective than placebo | ||||||
| Show | Effect of Cannabidiol on Drop Seizures in the Lennox-Gastaut Syndrome | Devinsky O. et al. | 2018 | Cannabidiol | Controlled study | ||||||||
| Show | Multiple sclerosis; Spasticity; Ataxia | Effect of cannabinoids on spasticity and ataxia in multiple sclerosis. | Meinck HM, Schönle PW, Conrad B | 1989 | Cannabis | Controlled study | improvement of tremor, spasticity and ataxia | ||||||
| Show | Effect of cannabis and tobacco on emphysema in patients with spontaneous pneumothorax | Ruppert AM et al. | 2018 | Cannabis | Controlled study;Open study | Cannabis use may accelerate the development of emphysema in tobacco smokers | |||||||
| Show | Psychosis/schizophrenia | Effect of cannabis on weight and metabolism in first-episode non-affective psychosis: Results from a three-year longitudinal study. | Vázquez-Bourgon J, et al. | 2019 | Cannabis | Open study | Cannabis use may produce a protective effect against weight gain in psychosis | ||||||
| Show | Pain | Effect of cannabis use in people with chronic non-cancer pain prescribed opioids: findings from a 4-year prospective cohort study. | Campbell G. et al. | 2018 | Cannabis | Open study | Pain patients who use cannabis have greater pain severity than non-users | ||||||
| Show | Psychosis/schizophrenia | Effect of continued cannabis use on medication adherence in the first two years following onset of psychosis | Schoeler T, Petros N, Di Forti M, Klamerus E, Foglia E, Murray R, Bhattacharyya S | 2017 | Cannabis | Open study | Heavy cannabis use may reduce adherence to medication in patients with psychosis | ||||||
| Show | Effect of Delta(9)-tetrahydrocannabinol, a cannabinoid receptor agonist, on the triggering of transient lower oesophageal sphincter relaxations in dogs and humans. | Beaumont H, Jensen J, Carlsson A, Ruth M, Lehmann A, Boeckxstaens GE. | 2009 | Delta-9-THC | Controlled study | THC reduced acid reflux episodes in the first hour after a meal. | |||||||
| Show | Effect of Delta-9-tetrahydrocannabinol and cannabidiol on nocturnal sleep and early-morning behavior in young adults. | Nicholson AN, Turner C, Stone BM, Robson PJ. | 2004 | Cannabis;Delta-9-THC;Cannabidiol | Controlled study | THC had sedative effects, CBD had alerting effects | |||||||
| Show | Glaucoma | Effect of delta-9-tetrahydrocannabinol on intraocular pressure in humans. | Cooler P, Gregg JM | 1977 | Delta-9-THC | Controlled study | reduction in intraocular pressure | ||||||
| Show | Spasticity | Effect of Delta-9-THC on EMG Measurements in Human Spasticity | Truong XT, Hanigan WC | 1986 | Delta-9-THC | Controlled study | THC reduced several types of spastic manifestations | ||||||
| Show | Pain | Effect of dronabinol on central neuropathic pain after spinal cord injury: a pilot study. | Rintala DH, Fiess RN, Tan G, Holmes SA, Bruel BM. | 2010 | Delta-9-THC | Controlled study | No significant difference between THC and diphenhydramine. | ||||||
| Show | Appetite loss/weight loss;HIV/AIDS | Effect of dronabinol on nutritional status in HIV infection. | Struwe M, Kaempfer SH, Geiger CJ, Pavia AT, Plasse TF, Shepard KV, Ries K, Evans TG. | 1993 | Delta-9-THC | Controlled study | Trends toward weight gain, improved appetite, decreased symptom stress | ||||||
| Show | Multiple sclerosis;Spasticity | Effect of dronabinol on progression in progressive multiple sclerosis (CUPID): a randomised, placebo-controlled trial. | Zajicek J, Ball S, Wright D, Vickery J, Nunn A, Miller D, Cano MG, McManus D, Mallik S, Hobart J; on behalf of the CUPID investigator group. | 2013 | Delta-9-THC | Controlled study | THC, which was given for 36 months, had no effect on progression compared to placebo | ||||||
| Show | Effect of food on the pharmacokinetics of dronabinol oral solution versus dronabinol capsules in healthy volunteers | Oh DA, Parikh N, Khurana V, Cognata Smith C, Vetticaden S | 2017 | Other cannabinoids | Open study | Maximum blood concentrations after oral intake of THC were reached faster in a fasted state than in if taken together with a meal | |||||||
| Show | Glaucoma | Effect of marihuana on intraocular and blood pressure in glaucoma. | Merritt JC, Crawford WJ, Alexander PC, Anduze AL, Gelbart SS | 1980 | Cannabis | Controlled study | Marihuana inhalation decreased intraocular and blood pressure. | ||||||
| Show | Traumatic brain injury | Effect of marijuana use on outcomes in traumatic brain injury. | Nguyen BM, Kim D, Bricker S, Bongard F, Neville A, Putnam B, Smith J, Plurad D. | 2014 | Cannabis | Open study | A positive THC screen is associated with decreased mortality in adult patients sustaining TBI [traumatic brain injury]. | ||||||
| Show | Pain;Parkinson's disease | Effect of medical cannabis on thermal quantitative measurements of pain in patients with Parkinson's disease. | Shohet A, Khlebtovsky A, Roizen N, Roditi Y, Djaldetti R. | 2016 | Cannabis | Open study | Cannabis use improved pain and movement | ||||||
| Show | Parkinson's disease | Effect of medical cannabis on thermal quantitative measurements of pain in patients with Parkinson's disease. | Shohet A, Khlebtovsky A, Roizen N, Roditi Y, Djaldetti R. | 2016 | Cannabis | Open study | Cannabis improves pain and movement in patients with Parkinson’s disease | ||||||
| Show | Nausea/vomiting | Effect of nabilone on nausea and vomiting after total abdominal hysterectomy. | Lewis IH, Campbell DN, Barrowcliffe MP. | 1994 | Nabilone | Controlled study | Nabilone and metoclopramide were equally effective in reducing nausea and vomiting | ||||||
| Show | Glaucoma | Effect of Sublingual Application of Cannabinoids on Intraocular Pressure: A Pilot Study. | Tomida I, Azuara-Blanco A, House H, Flint M, Pertwee RG, Robson PJ. | 2006 | Delta-9-THC;Cannabidiol | Controlled study | Significant reduction of intraocular pressure | ||||||
| Show | Multiple sclerosis | Effect of tetrahydrocannabinol:cannabidiol oromucosal spray on activities of daily living in multiple sclerosis patients with resistant spasticity: a retrospective, observational study. | Mallada Frechín J. | 2018 | Other cannabinoids | Survey | A cannabis spray has positive effects on activities of daily living in patients with Multiple Sclerosis | ||||||
| Show | Pain | Effect profile of paracetamol, Δ9-THC and promethazine using an evoked pain test battery in healthy subjects | van Amerongen G, Siebenga P, de Kam ML, Hay JL, Groeneveld GJ | 2018 | Delta-9-THC | Open study | Acute pain is reduced by THC | ||||||
| Show | Spasticity | Effective treatment of spasticity using dronabinol in pediatric palliative care. | Kuhlen M, Hoell JI, Gagnon G, Balzer S, Oommen PT, Borkhardt A, Janßen G. | 2016 | Delta-9-THC | In the majority of pediatric palliative patients the treatment with dronabinol showed promising effects in treatment resistant spasticit. | |||||||
| Show | Tourette's syndrome | Effective treatment of Tourette’s syndrome with marijuana. | Hemming M, Yellowlees PM. | 1993 | Cannabis | Uncontrolled case report | Improvement of symptoms with cannabis | ||||||
| Show | Sleep disorder | Effectiveness of Raw, Natural Medical Cannabis Flower for Treating Insomnia under Naturalistic Conditions. | Vigil JM, Stith SS, Diviant JP, Brockelman F, Keeling K, Hall B. | 2018 | Cannabis | Open study | The effect of cannabis on insomnia depended on the cannabis variety | ||||||
| Show | Effects of a cannabinoid receptor agonist on colonic motor and sensory functions in humans: a randomized, placebo-controlled study. | Esfandyari T, Camilleri M, Busciglio I, Burton D, Baxter K, Zinsmeister AR. | 2007 | Delta-9-THC | Controlled study | THC relaxes the colon and reduces postprandial colonic motility | |||||||
| Show | Parkinson's disease | Effects of cannabidiol in the treatment of patients with Parkinson's disease: an exploratory double-blind trial | Chagas MH, Zuardi AW, Tumas V, Pena-Pereira MA, Sobreira ET, Bergamaschi MM, dos Santos AC, Teixeira AL, Hallak JE, Crippa JA | 2014 | Cannabidiol | Controlled study | Significant improvement in well-being. No effects on motor functioning or neuroprotection. | ||||||
| Show | Effects of cannabidiol on brain excitation and inhibition systems; a randomised placebo-controlled single dose trial during magnetic resonance spectroscopy in adults with and without autism spectrum disorder. | Pretzsch CM, et al. | 2019 | Cannabidiol | Controlled study | No hint of efficacy of CBD in autism | |||||||
| Show | Effects of chronic marijuana use on driving performance | Doroudgar S, Mae Chuang H, Bohnert K, Canedo J, Burrowes S, Perry PJ. | 2018 | Cannabis | Open study | Regular cannabis users had lower driving abilities | |||||||
| Show | Anxiety | Effects of delta-9-tetrahydrocannabinol on evaluation of emotional images. | Ballard ME, Bedi G, de Wit H. | 2012 | Delta-9-THC | Controlled study | THC renders fearful faces less fearful | ||||||
| Show | Appetite loss/weight loss;Alzheimer's disease | Effects of dronabinol on anorexia and disturbed behavior in patients with Alzheimer's disease. | Volicer L, Stelly M, Morris J, McLaughlin J, Volicer BJ | 1997 | Delta-9-THC | Controlled study | higher weight gain with THC; reduction of disturbed behaviour with THC | ||||||
| Show | Pain | Effects of intravenous tetrahydrocannabinol on experimental and surgical pain. Psychological correlates of the analgesic response. | Raft D, Gregg J, Ghia J, Harris L | 1977 | Delta-9-THC | Controlled study | No pain relief with THC | ||||||
| Show | Pain | Effects of Legal Access to Cannabis on Scheduled II-V Drug Prescriptions. | Stith SS, Vigil JM, Adams IM, Reeve AP | 2018 | Cannabis | Open study | Legal access to cannabis may reduce the treatment with other medicinal drugs | ||||||
| Show | Effects of Medical Marijuana on Migraine Headache Frequency in an Adult Population. | Rhyne DN, Anderson S, Gedde M, Borgelt LM. | 2016 | Other cannabinoids | Controlled study | Migraine headache frequency on average decreased from 10.4 to 4.6 headaches per month with the use of cannabis. | |||||||
| Show | Pain | Effects of moderate and high doses of marihuana on thermal pain: a sensory decision theory analysis. | Clark WC, Janal MN, Zeidenberg P, Nahas GG. | 1981 | Cannabis | Controlled study | Cannabis increased perseption of pain | ||||||
| Show | Pain | Effects of nabilone, a synthetic cannabinoid, on postoperative pain. | Beaulieu P. | 2006 | Nabilone | Controlled study | No pain reduction with nabilone. | ||||||
| Show | Nausea/vomiting;Cancer;Cancer chemotherapy | Effects of smoked cannabis and oral delta-9-tetrahydrocannabinol on nausea and emesis after cancer chemotherapy: A review of state clinical trials. | Musty RE, Rossi R. | 2001 | Cannabis;Delta-9-THC | Open study | Cannabis caused symptom relief in 70-100%, dronabinol caused symptom relief in 76-88% | ||||||
| Show | Asthma | Effects of smoked marijuana in experimentally induced asthma. | Tashkin DP, Shapiro BJ, Lee YE, Harper CE | 1975 | Cannabis | Controlled study | after experimental induction of acute bronchospasm prompt correction of the bronchospasm with cannabis | ||||||
| Show | Appetite loss/weight loss | Effects of smoked marijuana on food intake and body weight of humans living in a residential laboratory. | Foltin RW, Fischman MW, Byrne MF. | 1988 | Cannabis | Controlled study | Increases in body weight during periods of active marijuana smoking were greater than predicted by caloric intake alone. | ||||||
| Show | Glaucoma | Effects of tetrahydrocannabinol on arterial and intraocular hypertension. | Crawford WJ, Merritt JC | 1979 | Cannabis | Controlled study | drop in IOP parallel with drop in arterial blood pressure | ||||||
| Show | Effects of tetrahydrocannabinol on balance and gait in patients with dementia: A randomised controlled crossover trial. | van den Elsen GA, Tobben L, Ahmed AI, Verkes RJ, Kramers C, Marijnissen RM, Olde Rikkert MG, van der Marck MA. | 2016 | Delta-9-THC | Controlled study | No differences in the number and type of adverse events were found, and no falls occurred after administration of THC. | |||||||
| Show | Multiple sclerosis;Spasticity | Effects on Spasticity and Neuropathic Pain of an Oral Formulation of Δ9-Tetrahydrocannabinol in Patients With Progressive Multiple Sclerosis. | van Amerongen G, Kanhai K, Baakman AC, Heuberger J, Klaassen E, Beumer TL, Strijers RL, Killestein J, van Gerven J, Cohen A, Groeneveld GJ | 2017 | Delta-9-THC | Controlled study | THC showed mixed results in the treatment of pain and spasticity in multiple sclerosis | ||||||
| Show | Appetite loss/weight loss | Efficacy and Safety of Appetite-Stimulating Medications in the Inpatient Setting | Howard ML, Hossaini R, Tolar C, Gaviola ML. | 2018 | Delta-9-THC | Open study | No difference on reduced appetite between THC, megestrol and mirtazapine | ||||||
| Show | Efficacy and Safety of Cannabidiol and Tetrahydrocannabivarin on Glycemic and Lipid Parameters in Patients With Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Pilot Study. | Jadoon KA, Ratcliffe SH, Barrett DA, Thomas EL, Stott C, Bell JD, O'Sullivan SE, Tan GD. | 2016 | Other cannabinoids | Controlled study | THCV significantly decreased fasting plasma glucose and improved the function of cells in the pancreas | |||||||
| Show | Efficacy and safety of dexanabinol in severe traumatic brain injury: results of a phase III randomised, placebo-controlled, clinical trial. | Maas AI, Murray G, Henney H 3rd, Kassem N, Legrand V, Mangelus M, Muizelaar JP, Stocchetti N, Knoller N; Pharmos TBI investigators. | 2006 | Other cannabinoids | Controlled study | No effect of dexanabinol | |||||||
| Show | Appetite loss/weight loss;HIV/AIDS | Efficacy and tolerability of high-dose dronabinol maintenance in HIV-positive marijuana smokers: a controlled laboratory study. | Bedi G, Foltin RW, Gunderson EW, Rabkin J, Hart CL, Comer SD, Vosburg SK, Haney M. | 2010 | Delta-9-THC | Controlled study | Tolerance developed to the appetite-increasing effects of THC. | ||||||
| Show | Efficacy and tolerance of the cream containing structured physiological lipids with endocannabinoids in the treatment of uremic pruritus: a preliminary study. | Szepietowski JC, Szepietowski T, Reich A. | 2005 | Other cannabinoids | Open study | Improvement of pruritus with the cream | |||||||
| Show | Epilepsy | Efficacy of cannabinoids in paediatric epilepsy | Ali S, Scheffer IE, Sadleir LG. | 2018 | Cannabidiol | Controlled study | CBD is similar effective as established antiepileptic drugs | ||||||
| Show | Epilepsy | Efficacy of CBD-enriched medical cannabis for treatment of refractory epilepsy in children and adolescents - An observational, longitudinal study | Hausman-Kedem M, Menascu S, Kramer U | 2018 | Cannabis | Open study | A cannabis extract with THC and CBD reduced seizures in epilepsy | ||||||
| Show | Nausea/vomiting;Cancer;Cancer chemotherapy | Efficacy of dronabinol alone and in combination with ondansetron versus ondansetron alone for delayed chemotherapy-induced nausea and vomiting. | Meiri E, Jhangiani H, Vredenburgh JJ, Barbato LM, Carter FJ, Yang HM, Baranowski V. | 2007 | Delta-9-THC | Controlled study | Dronabinol was as effective as ondansetron in reducing nausea and vomiting. Combination therapy was not more effective. | ||||||
| Show | Pain | Efficacy of dronabinol as an adjuvant treatment for chronic pain patients on opioid therapy | Narang S, Gibson D, Wasan AD, Ross EL, Michna E, Nedeljkovic SS, Jamison RN | 2007 | Delta-9-THC | Controlled study;Open study | THC had an additional effect on pain relief | ||||||
| Show | Pain | Efficacy of dronabinol as an adjuvant treatment for chronic pain patients on opioid therapy. | Narang S, Gibson D, Wasan AD, Ross EL, Michna E, Nedeljkovic SS, Jamison RN. | 2008 | Delta-9-THC | Controlled study | THC reduced pain | ||||||
| Show | Pain | Efficacy of Inhaled Cannabis on Painful Diabetic Neuropathy | Wallace MS, Marcotte TD, Umlauf A, Gouaux B, Atkinson JH | 2015 | Cannabis | Controlled study | Inhaled cannabis demonstrated a dose dependent reduction in peripheral treatment-refractory neuropathic pain. | ||||||
| Show | Nausea/vomiting;Cancer;Cancer chemotherapy | Efficacy of tetrahydrocannabinol in patients refractory to standard anti-emetic therapy | McCabe M, Smith FP, Goldberg D, Macdonald J, Woolley PV, Warren R | 1988 | Delta-9-THC | Controlled study | THC decreased nausea and vomiting in 23 of 36 (64%) patients | ||||||
| Show | Spasticity;Multiple sclerosis | Efficacy of tetrahydrocannabinol in patients refractory to standard antiemetic therapy.Efficacy, safety and tolerability of an orally administered cannabis extract in the treatment of spasticity in patients with multiple sclerosis: a randomized, double-blind, placebo-controlled, crossover study. | Vaney C, Heinzel-Gutenbrunner M, Jobin P, Tschopp F, Gattlen B, Hagen U, Schnelle M, Reif M. | 2004 | Cannabis | Controlled study | Significant reduction in spasm frequency in the 37 patients who received at least 90% of the dose. | ||||||
| Show | Pain | Efficacy of two cannabis based medicinal extracts for relief of central neuropathic pain from brachial plexus avulsion: results of a randomised controlled trial. | Berman JS, Symonds C, Birch R. | 2004 | Cannabis;Delta-9-THC | Controlled study | Significant pain relief and improvement of sleep | ||||||
| Show | Pain | Efficacy of two cannabis-based medicinal extracts for relief of central neuropathic pain from brachial plexus avulsion: results of a randomised controlled trial | Berman J, Lee J, Cooper M, Cannon A, Sach J, McKerral S, Taggart M, Symonds C, Fishel K, Birch R | 2003 | Cannabis;Delta-9-THC | Controlled study | Significant pain relief and improvement of sleep | ||||||
| Show | Employment and Marijuana Use Among Washington State Adolescents Before and After Legalization of Retail Marijuana. | Graves JM, Whitehill JM, Miller ME, Brooks-Russell A, Richardson SM, Dilley JA. | 2019 | Cannabis | Survey | Cannabis use in adolescents decreased in Washington State after legalisation | |||||||
| Show | Endocannabinoid receptor CB2R is significantly expressed in aspirin-exacerbated respiratory disease: a pilot study | Corrado A, Battle M, Wise SK, Lee FE, Guidot DM, DelGaudio JM, Molina SA, Levy JM | 2018 | Other cannabinoids | Controlled study | The number of CB2 receptors is increased in a certain respiratory disease | |||||||
| Show | Endocannabinoid system in systemic lupus erythematosus: First evidence for a deranged 2-arachidonoylglycerol metabolism | Navarini L et al. | 2018 | Other cannabinoids | Open study | Systemic lupus erythematosus was associated with an altered endocannabinoid system | |||||||
| Show | Endocannabinoids control platelet activation and limit aggregate formation under flow. | De Angelis V, Koekman AC, Weeterings C, Roest M, de Groot PG, Herczenik E, Maas C. | 2014 | Other cannabinoids | Open study | Activation of cannabinoid receptors by cannabis use reduces platelet activation and blood clotting. | |||||||
| Show | Epidemiological characteristics, safety and efficacy of medical cannabis in the elderly | Abuhasira R, Schleider LB, Mechoulam R, Novack V | 2018 | Cannabis | Open study | The medical use of cannabis is safe in elder people | |||||||
| Show | Multiple sclerosis | Evaluating Sativex® in Neuropathic Pain Management: A Clinical and Neurophysiological Assessment in Multiple Sclerosis. | Russo M, Naro A, Leo A, Sessa E, D'Aleo G, Bramanti P, Calabrò RS. | 2016 | Other cannabinoids | Open study | Cannabis reduced neuropathic pain | ||||||
| Show | Evaluation of divided attention psychophysical task performance and effects on pupil sizes following smoked, vaporized and oral cannabis administration | Newmeyer MN, Swortwood MJ, Taylor ME, Abulseoud OA, Woodward TH, Huestis MA | 2017 | Cannabis | Controlled study | Effects of inhaled and oral THC on pupil size and psychomotor performance | |||||||
| Show | Pain | Evaluation of herbal cannabis characteristics by medical users: a randomized trial. | Ware MA, Ducruet T, Robinson AR. | 2006 | Cannabis | Controlled study | Medical cannabis users can appreciate differences in herbal cannabis products | ||||||
| Show | Pain | Evaluation of intramuscular levonantradol and placebo in acute postoperative pain. | Jain AK, Ryan JR, McMahon FG, Smith G. | 1981 | Other cannabinoids | Controlled study | significant pain relief compared with placebo | ||||||
| Show | Nausea/vomiting;Appetite loss/weight loss | Evaluation of oral cannabinoid-containing medications for the management of interferon and ribavirin-induced anorexia, nausea and weight loss in patients treated for chronic hepatitis C virus. | Costiniuk CT, Mills E, Cooper CL | 2008 | Delta-9-THC;Nabilone | Open study | Improvement of appetite and reduction of nausea and vomiting by nabilone and dronabinol (THC) | ||||||
| Show | Pain | Experience of adjunctive cannabis use for chronic non-cancer pain: Findings from the Pain and Opioids IN Treatment (POINT) study. | Degenhardt L, Lintzeris N, Campbell G, Bruno R, Cohen M, Farrell M, Hall WD. | 2015 | Cannabis | Survey | Pain patients, who receive opioids, experience better pain relief if they also take cannabis. | ||||||
| Show | Pain | Experience with the synthetic cannabinoid nabilone in chronic noncancer pain. | Berlach DM, Shir Y, Ware MA. | 2006 | Nabilone | Open study | 9 patients reported reduced pain intensity | ||||||
| Show | Spasticity;Dystonia;Epilepsy;Anxiety | Experiences with THC-treatment in children and adolescents | Lorenz R | 2003 | Delta-9-THC | Uncontrolled case report | Positive effects of THC in children with severe neurological disorders | ||||||
| Show | Multiple sclerosis | Exploring cannabis use by patients with multiple sclerosis in a state where cannabis is legal. | Weinkle L, Domen CH, Shelton I, Sillau S, Nair K, Alvarez E. | 2018 | Cannabis | Survey | Many patients with multiple sclerosis use cannabis, if it is legal | ||||||
| Show | Dependency/withdrawal | Exploring the association of legalisation status of cannabis with problematic cannabis use and impulsivity in the USA. | Destrée L, Amiet D, Carter A, Lee R, Lorenzetti V, Segrave R, Youssef G, Solowij N, Yücel M. | 2018 | Cannabis | Open study | The status of legalisation in US states has no effect on problematic cannabis use | ||||||
| Show | Dependency/withdrawal | Falling rates of marijuana dependence among heavy users. | Davenport S. | 2018 | Cannabis | Open study | The risk of dependence formation among heavy cannabis users in the USA declined in the past 15 years | ||||||
| Show | Pain | Fatty Acid Amide Hydrolase Inhibitor Treatment in Men With Chronic Prostatitis/Chronic Pelvic Pain Syndrome: An Adaptive Double-blind, Randomized Controlled Trial. | Wagenlehner FM, et al. | 2017 | Other cannabinoids | Controlled study | An inhibitor of FAAH did not influence pain in patients with chronic prostatitis | ||||||
| Show | Dependency/withdrawal | Greater risk for frequent marijuana use and problems among young adult marijuana users with a medical marijuana card. | Tucker JS, Rodriguez A, Pedersen ER, Seelam R, Shih RA, D'Amico EJ. | 2018 | Cannabis | Open study | Adolescents, who are allowed to use medical cannabis, use cannabis more often | ||||||
| Show | Psychosis/schizophrenia | GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia. | Pasman JA, et al. | 2018 | Cannabis | Open study | Genetic investigation shows positive influence of schizophrenia risk on cannabis use | ||||||
| Show | HIV/AIDS | Heavy Cannabis Use Associated With Reduction in Activated and Inflammatory Immune Cell Frequencies in Antiretroviral Therapy-Treated Human Immunodeficiency Virus-Infected Individuals | Manuzak JA et al. | 2018 | Cannabis | Open study | Heavy cannabis use in patients with HIV is associated with improved immune function | ||||||
| Show | Hemp for headache: An in-depth historical and scientific review of cannabis in migraine treatment. | Russo EB | 2001 | Cannabis | Uncontrolled case report | Cannabis may be effective in the treatment of headache | |||||||
| Show | Pain | Herbal cannabis use in patients labeled as fibromyalgia is associated with negative psychosocial parameters. | Ste-Marie PA, Fitzcharles MA, Gamsa A, Ware MA, Shir Y. | 2012 | Cannabis | Survey | Many patients with fibromyalgia use cannabis products. | ||||||
| Show | HIV/AIDS | High-intensity cannabis use associated with lower plasma human immunodeficiency virus-1 RNA viral load among recently infected people who use injection drugs. | Milloy MJ, Marshall B, Kerr T, Richardson L, Hogg R, Guillemi S, Montaner JS, Wood E. | 2015 | Cannabis | Open study | At least daily cannabis use was associated with significant lower plasma HIV viral loads. | ||||||
| Show | Dependency/withdrawal | High-intensity cannabis use is associated with retention in opioid agonist treatment: a longitudinal analysis. | Socías ME, Wood E, Lake S, Nolan S, Fairbairn N, Hayashi K, Shulha HP, Liu S, Kerr T, Milloy MJ. | 2018 | Cannabis | Open study | Drug addicts have higher retention to opioid replacement treatment if they use cannabis | ||||||
| Show | Epilepsy | Higher cannabidiol plasma levels are associated with better seizure response following treatment with a pharmaceutical grade cannabidiol. | Szaflarski JP, Hernando K, Bebin EM, Gaston TE, Grayson LE, Ampah SB, Moreadith R. | 2019 | Cannabidiol | Open study | Efficacy of CBD in epilepsy is correlated to blood levels | ||||||
| Show | Gastrointestinal disorder | Higher odds of irritable bowel syndrome among hospitalized patients using cannabis: a propensity-matched analysis. | Adejumo AC, Ajayi TO, Adegbala OM, Bukong TN. | 2019 | Cannabis | Survey | Patients with irritable bowel syndrome are more likely to use cannabis | ||||||
| Show | Histamine induced responses are attenuated by a cannabinoid receptor agonist in human skin. | Dvorak M, Watkinson A, McGlone F, Rukwied R. | 2003 | Other cannabinoids | Controlled study | Peripheral administration of HU210 attenuates histamine-induced itch | |||||||
| Show | HIV/AIDS | HIV-infected cannabis users have lower circulating CD16+ monocytes and IFN-γ-inducible protein 10 levels compared with nonusing HIV patients | Rizzo MD et al. | 2018 | Cannabis | Controlled study | Cannabis may slow inflammation of the brain in patients with HIV and may maintain cognitive performance | ||||||
| Show | How does marijuana affect outcomes after trauma in ICU patients? A propensity-matched analysis | Singer M, Azim A, O'Keeffe T, Khan M, Jain A, Kulvatunyou N, Gries L, Jehan F, Tang A, Joseph B | 2017 | Cannabis | Open study | Cannabis use may decrease mortality in trauma patients | |||||||
| Show | Nausea/vomiting | Hyperemesis Gravidarum and Clinical Cannabis: To Eat or Not to Eat? | Curry W-NL | 2002 | Cannabis | Uncontrolled case report | Cannabis effective in treating nausea and vomiting in pregnant women | ||||||
| Show | Illicit drug use and prescription drug misuse among young adult medical cannabis patients and non-patient users in Los Angeles. | Fedorova EV, et al. | 2019 | Cannabis | Open study | The medical use of cannabis was associated with lower probability of illegal drug use in the USA | |||||||
| Show | Inflammation | Impact of cannabis treatment on the quality of life, weight and clinical disease activity in inflammatory bowel disease patients: a pilot prospective study. | Lahat A, Lang A, Ben-Horin S. | 2011 | Cannabis | Open study | Significant improvement of several symptoms. | ||||||
| Show | Gastrointestinal disorder;Inflammation | Impact of cannabis treatment on the quality of life, weight and clinical disease activity in inflammatory bowel disease patients: a pilot prospective study | Lahat A, Lang A, Ben-Horin S | 2012 | Cannabis | Open study | Improvement in general health perception, social functioning, ability to work, physical pain and depression; weight gain; average rise in BMI; average Harvey-Bradshaw index was reduced | ||||||
| Show | Dependency/withdrawal | Impact of Cannabis Use during Stabilization on Methadone Maintenance Treatment. | Scavone JL, Sterling RC, Weinstein SP, Van Bockstaele EJ. | 2013 | Cannabis | Open study | Objective ratings of opiate withdrawal decreased in patients using cannabis during stabilization | ||||||
| Show | Dependency/withdrawal | Impact of cannabis use during stabilization on methadone maintenance treatment. | Scavone JL, Sterling RC, Weinstein SP, Van Bockstaele EJ. | 2013 | Cannabis | Open study | Symptoms of opiate withdrawal decrease in patients undergoing methadone maintenance treatment, who use cannabis. | ||||||
| Show | Posttraumatic stress disorder | Impact of Cannabis Use on Treatment Outcomes among Adults Receiving Cognitive-Behavioral Treatment for PTSD and Substance Use Disorders | Ruglass LM, et al. | 2017 | Cannabis | Open study | Cannabis use had no relevant influence on outcome of behavioural therapies for co-occurring PTSD and substance use disorders | ||||||
| Show | Pain | Impact of co-administration of oxycodone and smoked cannabis on analgesia and abuse liability | Cooper ZD, Bedi G, Ramesh D, Balter R, Comer SD, Haney M | 2018 | Cannabis | Open study | Cannabis enhances the pain reducing effects of the opioid oxycodone according to experimental study | ||||||
| Show | Sleep disorder | Impact of Dronabinol on Quantitative Electroencephalogram (qEEG) Measures of Sleep in Obstructive Sleep Apnea Syndrome. | Farabi SS, Prasad B, Quinn L, Carley DW. | 2014 | Delta-9-THC | Open study | THC treatment yielded a shift in EEG (electroencephalogram) power toward delta and theta frequencies and a strengthening of normal rhythms in the sleep. | ||||||
| Show | Cancer | Impact of Medical Cannabis on Patient-Reported Symptoms for Patients With Cancer Enrolled in Minnesota's Medical Cannabis Program. | Anderson SP, Zylla DM, McGriff DM, Arneson TJ. | 2019 | Cannabis | Open study | Cancer patients report symptom relief by cannabis | ||||||
| Show | Pain | Impact of Medical Marijuana Legalization on Opioid Use, Chronic Opioid Use, and High-risk Opioid Use. | Shah A, Hayes CJ, Lakkad M, Martin BC. | 2019 | Cannabis | Survey | The legalisation of medical cannabis in the USA is associated with lower opioid use | ||||||
| Show | Psychosis/schizophrenia | Impact of substance use disorder on gray matter volume in schizophrenia. | Quinn M, McHugo M, Armstrong K, Woodward N, Blackford J, Heckers S. | 2018 | Cannabis | Controlled study | Cannabis use does not influence gray matter of the brain in schizophrenia | ||||||
| Show | Improvement in refractory obsessive compulsive disorder with dronabinol. | Schindler F, Anghelescu I, Regen F, Jockers-Scherubl M. | 2008 | Delta-9-THC | Uncontrolled case report | Significant symptom improvement | |||||||
| Show | Improvement in refractory psychosis with dronabinol: four case reports. | Schwarcz G, Karajgi B. | 2010 | Delta-9-THC | Uncontrolled case report | Significant improvement in four patients | |||||||
| Show | Appetite loss/weight loss;Cancer;Nausea/vomiting;Pain | Improving Quality of Life With Nabilone During Radiotherapy Treatments for Head and Neck Cancers: A Randomized Double-Blind Placebo-Controlled Trial | Côté M, Trudel M, Wang C, Fortin A. | 2015 | Nabilone | Controlled study | Nabilone did not reduce pain and nausea in patients treated for head and neck cancer. | ||||||
| Show | Increased Blood Pressure Following Abrupt Cessation of Daily Cannabis Use. | Vandrey R, Umbricht A, Strain EC. | 2011 | Cannabis;Nabilone | Survey | In 6 of 13 subjects blood pressure increased significantly after cessation of cannabis use. | |||||||
| Show | Individual prolactin reactivity modulates response of nucleus accumbens to erotic stimuli during acute cannabis intoxication: an fMRI pilot study | Androvicova R, et al. | 2017 | Cannabis | Open study | Cannabis increases the reaction to erotic stimuli | |||||||
| Show | Nausea/vomiting;Cancer;Cancer chemotherapy | Inhalation marijuana as an antiemetic for cancer chemotherapy. | Vinciguerra V, Moore T, Brennan E. | 1988 | Cannabis | Open study | Marijuana effective as antiemetic agent | ||||||
| Show | Pain | Initial experiences with medicinal extracts of cannabis for chronic pain: results from 34 'N of 1' studies. | Notcutt W, Price M, Miller R, Newport S, Phillips C, Simmons S, Sansom C. | 2004 | Cannabis | Controlled study | Improvement of pain | ||||||
| Show | Dependency/withdrawal | Intentional cannabis use to reduce crack cocaine use in a Canadian setting: A longitudinal analysis | Socías ME et al. | 2017 | Cannabis | Open study | Cannabis use reduced crack use | ||||||
| Show | Epilepsy | Interactions between cannabidiol and commonly used antiepileptic drugs | Gaston TE, Bebin EM, Cutter GR, Liu Y, Szaflarski JP; UAB CBD Program | 2017 | Cannabidiol | Open study | : CBD interacts with other anti-epileptic drugs | ||||||
| Show | Dependency/withdrawal | Intermittent marijuana use is associated with improved retention in naltrexone treatment for opiate-dependence. | Raby WN, Carpenter KM, Rothenberg J, Brooks AC, Jiang H, Sullivan M, Bisaga A, Comer S, Nunes EV | 2009 | Cannabis | Open study | Better adherence to natrexone therapy with intermittend cannabis use | ||||||
| Show | Intestinal Lymphatic Transport Enhances the Post-Prandial Oral Bioavailability of a Novel Cannabinoid Receptor Agonist Via Avoidance of First-Pass Metabolism. | Trevaskis NL, Shackleford DM, Charman WN, Edwards GA, Gardin A, Appel-Dingemanse S, Kretz O, Galli B, Porter CJ. | 2009 | Other cannabinoids | Controlled study | Systemic bioavailability of the cannabinoid CRA13 increased by more than 4-fold if taken together with a fat-rich meal. | |||||||
| Show | Nausea/vomiting;Cancer;Cancer chemotherapy | Intractable nausea and vomiting due to gastrointestinal mucosal metastases relieved by tetrahydrocannabinol (dronabinol). | Gonzalez-Rosales F, Walsh D | 1997 | Delta-9-THC | Uncontrolled case report | patients was treated with several antiemetic drugs, but it was not until dronabinol was added that the nausea and vomiting stopped | ||||||
| Show | Pain | Intractable neuropathic pain due to ulnar nerve entrapment treated with cannabis and ketamine 10%. | Hesselink JM, Kopsky DJ. | 2012 | Cannabis | Uncontrolled case report | Significant pain improvement with cannabis and ketamine. | ||||||
| Show | Investigating the Relationships Between Alcohol Consumption, Cannabis Use, and Circulating Cytokines: A Preliminary Analysis | Karoly HC, Bidwell LC, Mueller RL, Hutchison KE | 2018 | Cannabis | Open study | Cannabinoid compounds may serve to mitigate inflammation associated with alcohol use | |||||||
| Show | Inflammation | Investigating the Relationships Between Alcohol Consumption, Cannabis Use, and Circulating Cytokines: A Preliminary Analysis | Karoly HC, Bidwell LC, Mueller RL, Hutchison KE. | 2018 | Cannabis | Open study | Cannabis use mitigates inflammation associated with alcohol use | ||||||
| Show | Is Cannabis Use Associated with Various Indices of Motivation Among Adolescents? | Pacheco-Colón I, Coxe S, Musser ED, Duperrouzel JC, Ross JM, Gonzalez R | 2017 | Cannabis | Open study | ||||||||
| Show | Joint culpability: The effects of medical marijuana laws on crime | Yu-Wei LukeChu & WilburTownsend | 2018 | Cannabis | Open study | Medical cannabis laws in the USA not associated with crime | |||||||
| Show | Bipolar disorders | Joint Effects: A Pilot Investigation of the Impact of Bipolar Disorder and Marijuana Use on Cognitive Function and Mood | Sagar KA, Dahlgren MK, Racine MT, Dreman MW, Olson DP, Gruber SA. | 2016 | Cannabis | Open study | Cannabis may be helpful in bipolar disorder | ||||||
| Show | Gastrointestinal disorder;Inflammation;Pain | Konikoff FM. Cannabis induces a clinical response in patients with Crohn's disease: a prospective placebo-controlled study | Naftali T, Bar-Lev Schleider L, Dotan I, Lansky EP, Sklerovsky Benjaminov F, Konikoff FM | 2013 | Cannabis | Controlled study | Cannabis produced significant clinical benefits in 10 of 11 patients with active Crohn’s disease. | ||||||
| Show | Pain | Lack of analgesia by oral standardized cannabis extract on acute inflammatory pain and hyperalgesia in volunteers. | Kraft B, Frickey NA, Kaufmann RM, Reif M, Frey R, Gustorff B, Kress HG. | 2008 | Cannabis | Controlled study | The cannabis extract showed no analgesic effect in acute experimental pain | ||||||
| Show | Pain | Lack of analgesic efficacy of oral delta-9-tetrahydrocannabinol in postoperative pain. | Buggy DJ, Toogood L, Maric S, Sharpe P, Lambert DG, Rowbotham DJ | 2003 | Delta-9-THC | Controlled study | 5 mg was ineffective in reduding postoperative pain. | ||||||
| Show | Pain | Lack of effect of cannabidiol in sustained neuropathia. | Lindstrom P, Lindblom U, Boreus L. | 1987 | Cannabidiol | Controlled study | no effect of CBD on pain | ||||||
| Show | Spasticity;Multiple sclerosis | Lack of effect of cannabis-based treatment on clinical and laboratory measures in multiple sclerosis. | Centonze D, Mori F, Koch G, Buttari F, Codecà C, Rossi S, Cencioni MT, Bari M, Fiore S, Bernardi G, Battistini L, Maccarrone M. | 2009 | Cannabis | Controlled study | There was no effect of the cannabis extract on spasticity | ||||||
| Show | Pain | Lack of effect of central nervous system-active doses of nabilone on capsaicin-induced pain and hyperalgesia. | Kalliomäki J, Philipp A, Baxendale J, Annas P, Karlsten R, Segerdahl M. | 2012 | Nabilone | Controlled study | The cannabinoid had no significant effect on acute experimental pain. | ||||||
| Show | Lifetime marijuana use in relation to insulin resistance in lean, overweight and obese U.S. adults | Ngueta G, Ndjaboue R. | 2019 | Open study | Cannabis may have a protective effects against diabetes in obese individuals | ||||||||
| Show | Long lasting effects of chronic heavy cannabis abuse | Nestoros JN, Vakonaki E, Tzatzarakis MN, Alegakis A, Skondras MD, Tsatsakis AM | 2017 | Cannabis | Open study | Very heavy cannabis use may have long-lasting effects on the brain | |||||||
| Show | Long term marijuana users seeking medical cannabis in California (2001-2007): demographics, social characteristics, patterns of cannabis and other drug use of 4117 applicants. | O'Connell TJ, Bou-Matar CB. | 2007 | Cannabis | Survey | ||||||||
| Show | Multiple sclerosis | Long-term effectiveness and safety of nabiximols (tetrahydrocannabinol/cannabidiol oromucosal spray) in clinical practice. | Flachenecker P, Henze T, Zettl UK. | 2014 | Cannabis | Open study | Researchers found that “real-life data confirm the long-term effectiveness and tolerability of nabiximols [Sativex] for the treatment of resistant MSS [multiple sclerosis spasticity]. | ||||||
| Show | Appetite loss/weight loss;HIV/AIDS | Long-term efficacy and safety of dronabinol for acquired immunodeficiency syndrome-associated anorexia. | Beal JE, Olson R, Lefkowitz L, Laubenstein L, Bellman P, Yangco B, Morales JO, Murphy R, Powderly W, Plasse TF, Mosdell KW, Shepard KV | 1997 | Delta-9-THC | Open study | tendency to stable weight for 7 months | ||||||
| Show | Long-Term Heavy Recreational Cannabis Use and Serum Delta-9-Tetrahydrocannabinol Levels are not Associated with an Impaired Liver Function in Cannabis Dependents. | Bonnet U, Canbay A, Specka M, Scherbaum N. | 2018 | Cannabis | Open study | Heavy cannabis use has no relevant influence on liver function | |||||||
| Show | Epilepsy | Long-term safety and treatment effects of cannabidiol in children and adults with treatment-resistant epilepsies: Expanded access program results. | Szaflarski JP, et al. | 2018 | Cannabidiol | Open study | CBD was effective in several epilepsy forms in the long-term | ||||||
| Show | Epilepsy | Long-Term Safety, Tolerability, and Efficacy of Cannabidiol in Children with Refractory Epilepsy: Results from an Expanded Access Program in the US. | Sands TT, Rahdari S, Oldham MS, Caminha Nunes E, Tilton N, Cilio MR. | 2018 | Cannabidiol | Open study | Long-term observation of children with epilepsy treated with CBD | ||||||
| Show | Spasticity;Multiple sclerosis;Pain | Long-term use of a cannabis-based medicine in the treatment of spasticity and other symptoms in multiple sclerosis. | Wade DT, Makela PM, House H, Bateman C, Robson P. | 2006 | Cannabis | Open study | Long-term use of cannabis maintains its therapeutic effects | ||||||
| Show | Posttraumatic stress disorder | Loss of exercise- and stress-induced increases in circulating 2-arachidonoylglycerol concentrations in adults with chronic PTSD. | Crombie KM, Leitzelar BN, Brellenthin AG, Hillard CJ, Koltyn KF. | 2019 | Other cannabinoids | Controlled study | The endocannabinoid system shows a reduced activity in patients with post-traumatic stress disorder | ||||||
| Show | Multiple sclerosis;Pain | Low dose treatment with the synthetic cannabinoid Nabilone significantly reduces spasticity-related pain : A double-blind placebo-controlled cross-over trial. | Wissel J, Haydn T, Muller J, Brenneis C, Berger T, Poewe W, Schelosky LD. | 2006 | Nabilone | Controlled study | Significant reduction of pain | ||||||
| Show | Dependency/withdrawal | Low efficacy of non-opioid drugs in opioid withdrawal symptoms. | Hermann D, Klages E, Welzel H, Mann K, Croissant B. | 2005 | Cannabis | Survey | Only low efficacy of cannabis in alleviating opioid withdrawal symptoms | ||||||
| Show | Low-Dose Cannabidiol Is Safe but Not Effective in the Treatment for Crohn's Disease, a Randomized Controlled Trial. | Naftali T, et al. | 2017 | Cannabidiol | Controlled study | Very low doses of CBD were not effective in Crohn’s disease | |||||||
| Show | Pain | Low-dose vaporized cannabis significantly improves neuropathic pain | Wilsey B, Marcotte T, Deutsch R, Gouaux B, Sakai S, Donaghe H | 2013 | Cannabis | Controlled study | Cannabis reduced pain. No difference in efficacy between the two doses. | ||||||
| Show | Lower circulating endocannabinoid levels in children with autism spectrum disorder. | Aran A, et al. | 2019 | Open study | Children with autism have lower blood levels of endocannabinoids | ||||||||
| Show | Cancer | Many cancer patients use cannabis in Canada | Martell K, Fairchild A, LeGerrier B, Sinha R, Baker S, Liu H, Ghose A, Olivotto IA, Kerba M. | 2018 | Cannabis | Survey | Many cancer patients use cannabis in Canada | ||||||
| Show | Pain | Marihuana and pain. | Hill SY, Schwin R, Goodwin DW, Powell B. | 1974 | Cannabis | Controlled study | Cannabis increased pain sensitivity | ||||||
| Show | Spasticity;Pain | Marihuana as a therapeutic agent for muscle spasm or spasticity. | Petro DJ | 1980 | Cannabis | Uncontrolled case report | Relief from spasticity and pain | ||||||
| Show | Glaucoma | Marihuana smoking and intraocular pressure. | Hepler RS, Frank IR | 1971 | Cannabis | Open study | 9 of 11 had drop in intraocular pressure of 16-45% | ||||||
| Show | Tourette's syndrome | Marijuana and Tourette’s syndrome. | Sandyk R, Awerbuch G. | 1988 | Cannabis | Uncontrolled case report | The patients notes a significant amelioration of symptoms when smoking cannabis | ||||||
| Show | Nausea/vomiting;Cancer chemotherapy | Marijuana as antiemetic medicine: a survey of oncologists' experiences and attitudes. | Doblin RE, Kleiman MA. | 1991 | Cannabis | Survey | 54% of oncologists thought marijuana should be available on prescription | ||||||
| Show | Nausea/vomiting;HIV/AIDS;Pain;Depression;Anxiety | Marijuana Effectiveness as an HIV Self-Care Strategy. | Corless IB, Lindgren T, Holzemer W, Robinson L, Moezzi S, Kirksey K, Coleman C, Tsai YF, Sanzero Eller L, Hamilton MJ, Sefcik EF, Canaval GE, Rivero Mendez M, Kemppainen JK, Bunch EH, Nicholas PK, Nokes KM, Dole P, Reynolds N. | 2009 | Cannabis | Survey | Participants rated cannabis as similar effective as other medications for the treatment of their symptoms. | ||||||
| Show | Hiccups | Marijuana for intractable hiccups. | Gilson I, Busalacchi M. | 1998 | Cannabis | Uncontrolled case report | Smoking cannabis stopped hiccups that did not respond to usual medications on the 8th day | ||||||
| Show | Parkinson's disease | Marijuana for parkinsonian tremor. | Frankel JP, Hughes A, Lees AJ, Stern GM. | 1990 | Cannabis | Open study | No improvement of tremor | ||||||
| Show | Appetite loss/weight loss;Spasticity;Pain | Marijuana in the management of amyotrophic lateral sclerosis. | Carter GT, Rosen BS. | 2001 | Cannabis | Uncontrolled case report | Cannabis relieved several symptoms of ALS | ||||||
| Show | Marijuana smoking and markers of testicular function among men from a fertility centre | Nassan FL, et al. | 2019 | Cannabis | Open study | Cannabis use was associated with higher sperm concentration | |||||||
| Show | Glaucoma | Marijuana smoking and reduced pressure in human eyes: drug action or epiphenomenon? | Flom MC, Adams AJ, Jones RT | 1975 | Delta-9-THC | Open study | IOP reduction in 7 of 15 | ||||||
| Show | HIV/AIDS | Marijuana smoking does not accelerate progression of liver disease in HIV-hepatitis C coinfection: a longitudinal cohort analysis | Brunet L. et al. | 2013 | Cannabis | Open study | Cannabis does not increase the risk of liver fibrosis in patients co-infected with HIV and HCV | ||||||
| Show | HIV/AIDS | Marijuana smoking does not accelerate progression of liver disease in HIV-hepatitis C coinfection: a longitudinal cohort analysis. | Brunet L, Moodie EE, Rollet K, Cooper C, Walmsley S, Potter M, Klein MB; Canadian Co-infection Cohort Investigators. | 2013 | Cannabis | Open study | The use of cannabis did not accelerate progression to significant liver fibrosis. | ||||||
| Show | Nausea/vomiting;Cancer chemotherapy | Marijuana to prevent nausea and vomiting in cancer patients: a survey of clinical oncologists. | Schwartz RH, Voth EA, Sheridan MJ. | 1997 | Cannabis | Survey | Only a small percentage of oncologists prescribed marijuana | ||||||
| Show | Marijuana use and fecundability in a North American preconception cohort study | Wise LA1, Wesselink AK, Hatch EE, Rothman KJ, Mikkelsen EM, Sørensen HT, Mahalingaiah S | 2018 | Cannabis | Open study | ||||||||
| Show | Nausea/vomiting;HIV/AIDS | Marijuana use and its association with adherence to antiretroviral therapy among HIV-infected persons with moderate to severe nausea. | de Jong BC, Prentiss D, McFarland W, Machekano R, Israelski DM. | 2005 | Cannabis | Open study | Cannabis improved adherence to antiretroviral therapy in HIV/AIDS | ||||||
| Show | Depression | Marijuana use and major depressive disorder are additively associated with reduced verbal learning and altered cortical thickness. | Radoman M, Hoeppner SS, Schuster RM, Evins AE, Gilman JM. | 2019 | Cannabis | Open study | Cannabis may have negative effects on young people with depression | ||||||
| Show | Marijuana use and mortality following orthopedic surgical procedures. | Moon AS, Smith W, Mullen S, Ponce BA, McGwin G, Shah A, Naranje SM | 2018 | Cannabis | Open study | Cannabis use was associated with reduced mortality following orthopaedic surgery | |||||||
| Show | Marijuana Use and Renal Function Among US Adults | Lu C, Papatheodorou SI, Danziger J, Mittleman MA | 2018 | Cannabis | Open study | ||||||||
| Show | Marijuana use and short-term outcomes in patients hospitalized for acute myocardial infarction | Johnson-Sasso CP, Tompkins C, Kao DP, Walker LA. | 2018 | Cannabis | Open study | Cannabis use is associated with decreased mortality in hospital after a heart attack | |||||||
| Show | Marijuana Use Associations with Pulmonary Symptoms and Function in Tobacco Smokers Enrolled in the Subpopulations and Intermediate Outcome Measures in COPD Study | Morris, Madeline A. et al. | 2018 | Cannabis | Open study | Cannabis use is not associated with increased risks of respiratory diseases. | |||||||
| Show | HIV/AIDS | Marijuana Use Impacts Midlife Cardiovascular Events in HIV-Infected Men | 2017 | Cannabis | Open study | Cannabis use may increase the risk for heart attacks in HIV positives | |||||||
| Show | Epilepsy | Marijuana use in adults admitted to a Canadian epilepsy monitoring unit. | Massot-Tarrús A, McLachlan RS. | 2016 | Cannabis | Survey | Improvement in seizures, stress was decreased, sleep improved and memory/concentration was better | ||||||
| Show | Marijuana Use in Adults Living with Sickle Cell Disease. | Roberts JD, Spodick J, Cole J, Bozzo J, Curtis S, Forray A. | 2018 | Cannabis | Survey | Cannabis may have therapeutic effects in patients with sickle cell disease | |||||||
| Show | Nausea/vomiting;Appetite loss/weight loss;HIV/AIDS | Marijuana Use in HIV-Positive and AIDS Patients: Results of an Anonymous Mail Survey | Sidney S. | 2001 | Cannabis | Survey | 22.4 % used cannabis for medicinal purposes | ||||||
| Show | Cancer | Marijuana use is not associated with cervical human papillomavirus natural history or cervical neoplasia in HIV-seropositive or HIV-seronegative women. | D'Souza G, Palefsky JM, Zhong Y, Minkoff H, Massad LS, Anastos K, Levine AM, Moxley M, Xue XN, Burk RD, Strickler HD. | 2010 | Cannabis | Open study | Cannabis use is not associated with cervical human papillomavirus natural history or cervical neoplasia in HIV-seropositive or HIV-seronegative women. | ||||||
| Show | Marijuana Use is Protective in Burns | Williams F, Chrisco L, Nizamani R, Cairns B, Jones S | 2018 | Cannabis | Survey | Cannabis use reduces mortality in patients with burns | |||||||
| Show | Gastrointestinal disorder;Inflammation | Marijuana Use Patterns Among Patients with Inflammatory Bowel Disease. | Ravikoff Allegretti J, Courtwright A, Lucci M, Korzenik JR, Levine J. | 2013 | Cannabis | Survey | Patients find cannabis very helpful for symptom control. | ||||||
| Show | Dependency/withdrawal | Marijuana withdrawal in humans: effects of oral THC or divalproex. | Haney M, Hart CL, Vosburg SK, Nasser J, Bennett A, Zubaran C, Foltin RW. | 2004 | Delta-9-THC | Controlled study | THC abolished withdrawal symptoms | ||||||
| Show | Pain | Marijuana's Influence on Pain Scores, Initial Weight Loss, and Other Bariatric Surgical Outcomes. | Bauer FL, Donahoo WT, Hollis HW Jr, Tsai AG, Pottorf BJ, Johnson JM, Silveira LJ, Husain FA. | 2018 | Cannabis | Open study | Cannabis users need higher doses of opioids after surgery | ||||||
| Show | Epilepsy | Marijuana: an effective antiepileptic treatment in partial epilepsy? A case report and review of the literature. | Mortati K, Dworetzky B, Devinsky O. | 2007 | Cannabis | Uncontrolled case report | Significant improvement of epilepsy with the use of cannabis. | ||||||
| Show | Medical cannabis access, use, and substitution for prescription opioids and other substances: A survey of authorized medical cannabis patients | Lucas P, Walsh Z | 2017 | Cannabis | Survey | Patients prefer cannabis over opioids | |||||||
| Show | Pain | Medical Cannabis for the Treatment of Fibromyalgia | Habib G, Artul S. | 2018 | Cannabis | Open study | Cannabis may have a beneficial effect on patients with fibromyalgia | ||||||
| Show | Parkinson's disease | Medical Cannabis in Parkinson Disease: Real-Life Patients' Experience | Balash Y et al. | 2017 | Cannabis | Open study | Cannabis may be beneficial in Parkinson`s disease according to a survey | ||||||
| Show | Pain | Medical Cannabis in Patients with Chronic Pain: Effect on Pain Relief, Pain Disability, and Psychological aspects. A Prospective Non randomized Single Arm Clinical Trial. | Poli P, Crestani F, Salvadori C, Valenti I, Sannino C. | 2017 | Cannabis | Open study | Cannabis tea effective in the treatment of chronic pain | ||||||
| Show | Cancer | Medical Cannabis in the Palliation of Malignant Wounds—A Case Report | Maida V. | 2017 | Cannabis | Uncontrolled case report | Topical application of a cannabis extract helpful in cancer wound | ||||||
| Show | Pain | Medical Cannabis Legalization and Opioid Prescriptions: Evidence on US Medicaid Enrollees during 1993-2014. | Liang D, Bao Y, Wallace M, Grant I, Shi Y. | 2018 | Cannabis | Open study | Legalization of cannabis for medical use in the US is associated with reduced opioid prescriptions | ||||||
| Show | Medical cannabis patterns of use and substitution for opioids & other pharmaceutical drugs, alcohol, tobacco, and illicit substances; results from a cross-sectional survey of authorized patients. | Lucas P, Baron EP, Jikomes N. | 2019 | Cannabis | Survey | Cannabis patients reduce the use of other medicinal drugs and alcohol | |||||||
| Show | Cancer;Cancer chemotherapy | Medical Cannabis Use by Hodgkin Lymphoma Patients: Experience of a Single Center | Sarid N. et al. | 2018 | Cannabis | Open study | Patients with Hodgkin’s lymphoma may profit from a treatment with cannabis | ||||||
| Show | Cancer | Medical Cannabis Use in Glioma Patients Treated at a Comprehensive Cancer Center in Florida. | Reblin M, Sahebjam S, Peeri NC, Martinez YC, Thompson Z, Egan KM. | 2019 | Cannabis | Open study | Many patients with brain cancer use cannabis | ||||||
| Show | Posttraumatic stress disorder | Medical cannabis use in post-traumatic stress disorder: a naturalistic observational study. | Reznik I. | 2011 | Cannabis | Open study | In most cases a significant improvement in quality of life and pain, with some positive changes in severity of posttraumatic stress disorder was observed. | ||||||
| Show | Medical Cannabis Users' Comparisons between Medical Cannabis and Mainstream Medicine. | Kruger DJ, Kruger JS. | 2019 | Cannabis | Survey | Many patients substitute their stunning medication by cannabis | |||||||
| Show | Pain | Medical Cannabis: Effects on Opioid and Benzodiazepine Requirements for Pain Control. | O'Connell M, Sandgren M, Frantzen L, Bower E, Erickson B. | 2019 | Open study | Cannabis reduces opioid use by pain patients | |||||||
| Show | Medical marijuana laws and workplace fatalities in the United States. | Anderson DM, Rees DI, Tekin E. | 2018 | Cannabis | Open study | Medical cannabis laws in the USA are associated with improved workplace safety | |||||||
| Show | Medical marijuana laws are associated with increases in substance use treatment admissions by pregnant women. | Meinhofer A, Witman A, Murphy S, Bao Y. | 2019 | Cannabis | Open study | Legalisation of cannabis for medical use in the US increased cannabis use by pregnant women | |||||||
| Show | Medical Marijuana Laws May Be Associated With A Decline In The Number Of Prescriptions For Medicaid Enrollees | Bradford AC, Bradford WD | 2017 | Cannabis | Open study | The medical use of cannabis may reduce medical costs of Medicaid in the USA by about one billion dollars | |||||||
| Show | Cancer;Cancer chemotherapy | Medicinal cannabis does not influence the clinical pharmacokinetics of irinotecan and docetaxel. | Engels FK, de Jong FA, Sparreboom A, Mathot RA, Loos WJ, Kitzen JJ, de Bruijn P, Verweij J, Mathijssen RH. | 2007 | Cannabis | Open study | Cannabis did not influence the pharmacokinetics of the two anti-cancer drugs | ||||||
| Show | Medicinal cannabis in Australia, 2016: the Cannabis as Medicine Survey (CAMS-16). | Lintzeris N, Driels J, Elias N, Arnold JC, McGregor IS, Allsop DJ. | 2018 | Cannabis | Survey | Results of a survey among Australian patients, who treat themselves with cannabis | |||||||
| Show | Gastrointestinal disorder | Members of the endocannabinoid system are distinctly regulated in inflammatory bowel disease and colorectal cancer. | Grill M, et al. | 2019 | Other cannabinoids | Open study | The endocannabinoid system is altered in patients with irritable bowel syndrome and bowel cancer | ||||||
| Show | Posttraumatic stress disorder | Mitigation of post-traumatic stress symptoms by Cannabis resin: A review of the clinical and neurobiological evidence. | Passie T, Emrich HM, Karst M, Brandt SD, Halpern JH. | 2012 | Cannabis | Uncontrolled case report | Significant improvement in one patient with PSD with cannabis | ||||||
| Show | Posttraumatic stress disorder | Mitigation of post-traumatic stress symptoms by Cannabis resin: A review of the clinical and neurobiological evidence. | Passie T, Emrich HM, Karst M, Brandt SD, Halpern JH. | 2012 | Cannabis | Uncontrolled case report | Cannabis reduced course and intensity of symptoms. | ||||||
| Show | Moderate and vigorous physical activity patterns among marijuana users: Results from the 2007-2014 National Health and Nutrition Examination Surveys | Vidot DC, Bispo JB, Hlaing WM, Prado G, Messiah SE | 2017 | Cannabis | Open study | Cannabis use was associated with reduced recreational physical activity | |||||||
| Show | Inflammation | Modulation of Human Peripheral Blood Mononuclear Cell Signaling by Medicinal Cannabinoids | Utomo WK, et al. | 2017 | Open study | Cannabis use alters immune cells in a way, which supports beneficial effects in inflammatory diseases and cancer | |||||||
| Show | Nausea/vomiting | Motion sickness, stress and the endocannabinoid system. | Choukèr A, Kaufmann I, Kreth S, Hauer D, Feuerecker M, Thieme D, Vogeser M, Thiel M, Schelling G. | 2010 | Open study | Volunteers who developed acute motion sickness (n = 7) showed lower endocannabinoid levels during parabolic flights. | |||||||
| Show | Cancer;Pain | Multicenter, Double-Blind, Randomized, Placebo-Controlled, Parallel-Group Study of the Efficacy, Safety, and Tolerability of THC:CBD Extract and THC Extract in Patients With Intractable Cancer-Related Pain. | Johnson JR, Burnell-Nugent M, Lossignol D, Ganae-Motan ED, Potts R, Fallon MT. | 2010 | Cannabis;Delta-9-THC | Controlled study | A cannabis extract containing THC and CBD was superior in reducing pain than placebo. | ||||||
| Show | Multiple sclerosis;Pain;Spasticity | Multiple Sclerosis and Extract of Cannabis: results of the MUSEC trial. | Zajicek JP, Hobart JC, Slade A, Barnes D, Mattison PG; on behalf of the MUSEC Research Group. | 2012 | Cannabis | Controlled study | Significant improvement by the cannabis extract Cannador of spasticity and pain. | ||||||
| Show | Multiple sclerosis | Multiple Sclerosis and Use of Medical Cannabis: A Retrospective Review Evaluating Symptom Outcomes | McCormack K. et al. | 2019 | Cannabis | Open study | MS patients taking cannabis were able to reduce intake of opioids and benzodiazepines | ||||||
| Show | Tourette's syndrome | Müller-Vahl KR, Schneider U, Emrich HM. | Combined treatment of Tourette syndrome with delta-9-THC and dopamine receptor agonists. | 2002 | Delta-9-THC | Uncontrolled case report | THC may be combined with neuroleptics | ||||||
| Show | Nausea/vomiting;Cancer;Cancer chemotherapy | Nabilone and metoclopramide in the treatment of nausea and vomiting due to cisplatinum: a double blind study. | Crawford SM, Buckman R. | 1986 | Nabilone | Controlled study | No difference between nabilone and metoclopramide | ||||||
| Show | Nausea/vomiting;HIV/AIDS | Nabilone as effective therapy for intractable nausea and vomiting in AIDS. | Green ST, Nathwani D, Goldberg DJ, Kennedy DH. | 1989 | Nabilone | Uncontrolled case report | Intractable nausea and vomiting was effectively relieved with nabilone | ||||||
| Show | Dependency/withdrawal | Nabilone decreases marijuana withdrawal and a laboratory measure of marijuana relapse. | Haney M, Cooper ZD, Bedi G, Vosburg SK, Comer SD, Foltin RW. | 2013 | Nabilone | Open study | The use of nabilone reduced withdrawal symptoms. | ||||||
| Show | Pain | Nabilone for the treatment of pain in fibromyalgia. | Skrabek RQ, Galimova L, Ethansand Daryl K. | 2007 | Nabilone | Controlled study | Significant reduction of pain and improvement of quality of life with nabilone | ||||||
| Show | Pain | Nabilone for the treatment of pain in fibromyalgia. | Skrabek RQ, Galimova L, Ethans K, Perry D. | 2008 | Nabilone | Controlled study | Nabilone improved symptoms and was well-tolerated | ||||||
| Show | Cancer | Nabilone for the treatment of paraneoplastic night sweats: a report of four cases. | Maida V. | 2008 | Nabilone | Open study | Significant improvement of night sweats within 2 days | ||||||
| Show | Multiple sclerosis; Spasticity | Nabilone in the treatment of multiple sclerosis. | Martyn CN, Illis LS, Thom J | 1995 | Nabilone | Controlled study | improvement of muscle spasms and frequency of nocturia | ||||||
| Show | Nausea/vomiting;Cancer;Cancer chemotherapy | Nabilone versus prochlorperazine for control of cancer chemotherapy-induced emesis in children: a double-blind, crossover trial. | Chan HS, Correia JA, MacLeod SM | 1987 | Nabilone | Controlled study | Nabilone effective as antiemetic drug for children | ||||||
| Show | Nausea/vomiting;Cancer;Cancer chemotherapy | Nabilone: an alternative antiemetic for cancer chemotherapy. | Dalzell AM, Bartlett H, Lilleyman JS. | 1986 | Nabilone | Controlled study | Even for young children nabilone is an effective antiemetic, superior to domperidone. | ||||||
| Show | Nausea/vomiting;Cancer;Cancer chemotherapy | Nabilone: an effective antiemetic in patients receiving cancer chemotherapy. | Einhorn LH, Nagy C, Furnas B, Williams SD. | 1981 | Nabilone | Controlled study | Sixty patients (75 per cent) reported nabilone to be more effective than prochlorperazine for relief of nausea and vomiting. | ||||||
| Show | Multiple sclerosis | Nabiximols (THC/CBD oromucosal spray, Sativex®) in clinical practice--results of a multicenter, non-interventional study (MOVE 2) in patients with multiple sclerosis spasticity. | Flachenecker P, Henze T, Zettl UK. | 2014 | Cannabis | Open study | The cannabis extract Sativex provided relief in 74.6% of participants. | ||||||
| Show | Dependency/withdrawal | Nabiximols as an agonist replacement therapy during cannabis withdrawal: a randomized clinical trial | Allsop DJ, Copeland J, Lintzeris N, Dunlop AJ, Montebello M, Sadler C, Rivas GR, Holland RM, Muhleisen P, Norberg MM, Booth J, McGregor IS | 2014 | Cannabis | Controlled study | Sativex had no relevant long-term effect on cannabis dependence | ||||||
| Show | Cancer;Pain | Nabiximols for opioid-treated cancer patients with poorly-controlled chronic pain: a randomized, placebo-controlled, graded-dose trial. | Portenoy RK, Ganae-Motan ED, Allende S, Yanagihara R, Shaiova L, Weinstein S, McQuade R, Wright S, Fallon MT. | 2012 | Cannabis | Controlled study | Additional pain reduction following the two lower doses. | ||||||
| Show | Anxiety | Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: a preliminary report. | Crippa JA, Derenusson GN, Ferrari TB, Wichert-Ana L, Duran FL, Martin-Santos R, Simões MV, Bhattacharyya S, Fusar-Poli P, Atakan Z, Santos Filho A, Freitas-Ferrari MC, McGuire PK, Zuardi AW, Busatto GF, Hallak JE. | 2011 | Cannabidiol | Controlled study | CBD reduces anxiety in patients with generalized social anxiety disorder. | ||||||
| Show | Neural Effects of Cannabinoid CB1 Neutral Antagonist Tetrahydrocannabivarin on Food Reward and Aversion in Healthy Volunteers. | Tudge L, Williams C, Cowen PJ, McCabe C | 2015 | Other cannabinoids | Controlled study | The natural cannabinoid tetrahydrocannabivarin (THCV) altered the nerve response to pleasant and unpleasant stimuli in a way that it “suggests therapeutic activity in obesity. | |||||||
| Show | No Acute Effects of Cannabidiol on the Sleep-Wake Cycle of Healthy Subjects: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study | Linares IMP et al. | 2018 | Cannabidiol | Controlled study | CBD may be used against anxiety and depression without altering normal sleep | |||||||
| Show | Older adults' marijuana use, injuries, and emergency department visits | Choi NG, Marti CN, DiNitto DM, Choi BY | 2017 | Cannabis | Controlled study | Cannabis use may increase injury risk among older adults | |||||||
| Show | On the impact of cannabis consumption on traffic safety: a driving simulator study with habitual cannabis consumers. | Tank A, Tietz T, Daldrup T, Schwender H, Hellen F, Ritz-Timme S, Hartung B. | 2019 | Cannabis | Open study | In driving simulator tests 3 hours after cannabis consumption there were no longer significant faults. | |||||||
| Show | Dystonia; Parkinson's disease | Open label evaluation of cannabidiol in dystonic movement disorders. | Consroe P, Sandyk R, Snider SR | 1986 | Cannabidiol | Open study | 20-50% improvement of dystonia; deterioration of tremor and hypokinesia in 2 patients with Parkinson's disease | ||||||
| Show | Alzheimer's disease | Open-label study of dronabinol in the treatment of refractory agitation in Alzheimer’s disease: a pilot study | Ross JS, Shua-Haim JR | 2003 | Delta-9-THC | Open study | Significant reduction of agitation | ||||||
| Show | Epilepsy | Open-label use of Highly* purified CBD (Epidiolex®) in patients with CDKL5 deficiency disorder and Aicardi, Dup15q, and Doose syndromes. | Devinsky O, et al. | 2018 | Cannabidiol | Open study | CBD reduces seizures in several further childhood-onset epilepsy forms according to an open-label study | ||||||
| Show | Pain | Open-label, add-on study of tetrahydrocannabinol for chronic nonmalignant pain. | Haroutiunian S, Rosen G, Shouval R, Davidson E. | 2008 | Delta-9-THC | Open study | 5 patients reported adequate response to the treatment. | ||||||
| Show | Bipolar disorders | Opposite relationships between cannabis use and neurocognitive functioning in bipolar disorder and schizophrenia. | Ringen PA, Vaskinn A, Sundet K, Engh JA, Jónsdóttir H, Simonsen C, Friis S, Opjordsmoen S, Melle I, Andreassen OA. | 2010 | Cannabis | Survey | In bipolar disorder subjects, cannabis use was associated with better neurocognitive function, but the opposite was the case for the schizophrenia subjects. | ||||||
| Show | Oral Cannabidiol Use in Children With Autism Spectrum Disorder to Treat Related Symptoms and Co-morbidities. | Barchel D, Stolar O, De-Haan T, Ziv-Baran T, Saban N, Fuchs DO, Koren G, Berkovitch M. | 2019 | Cannabis | Open study | Cannabis may be helpful in autism | |||||||
| Show | Tourette's syndrome | Oral Delta 9-tetrahydrocannabinol improved refractory Gilles de la Tourette syndrome in an adolescent by increasing intracortical inhibition: a case report. | Hasan A, Rothenberger A, Münchau A, Wobrock T, Falkai P, Roessner V. | 2010 | Delta-9-THC | Uncontrolled case report | THC improved tics allowing parallel stimulant treatment of comorbid ADHD. | ||||||
| Show | Multiple sclerosis;Pain | Oromucosal ∆9-tetrahydrocannabinol/cannabidiol for neuropathic pain associated with multiple sclerosis: an uncontrolled, open-label, 2-year extension trial. | Rog DJ, Nurmikko TJ, Young CA. | 2007 | Cannabis | Open study | No development of tolerance within a period of two years of treatment | ||||||
| Show | Multiple sclerosis;Pain | Pain Modulation after Oromucosal Cannabinoid Spray (SATIVEX®) in Patients with Multiple Sclerosis: A Study with Quantitative Sensory Testing and Laser-Evoked Potentials. | Turri M, Teatini F, Donato F, Zanette G, Tugnoli V, Deotto L, Bonetti B, Squintani G | 2018 | Other cannabinoids | Open study | Cannabis reduces pain in multiple sclerosis | ||||||
| Show | Pain | Pain relief with oral cannabinoids in familial Mediterranean fever. | Holdcroft A, Smith M, Jacklin A, Hodgson H, Smith B, Newton M, Evans F | 1997 | Cannabis | Controlled study | reduction of need for morphin | ||||||
| Show | Gastrointestinal disorder | Palmitoylethanolamide and Cannabidiol Prevent Inflammation-induced Hyperpermeability of the Human Gut In Vitro and In Vivo-A Randomized, Placebo-controlled, Double-blind Controlled Trial. | Couch DG, Cook H, Ortori C, Barrett D, Lund JN, O'Sullivan SE. | 2019 | Cannabidiol | Controlled study | CBD and palmitoylethanolamine may be helpful in inflammatory bowel disease | ||||||
| Show | Palmitoylethanolamide as adjunctive therapy for autism: Efficacy and safety results from a randomized controlled trial. | Khalaj M. et al. | 2018 | Other cannabinoids | Controlled study | ||||||||
| Show | Pain | Palmitoylethanolamide in the Treatment of Chronic Pain Caused by Different Etiopathogenesis. | Gatti A, Lazzari M, Gianfelice V, Di Paolo A, Sabato E, Sabato AF. | 2012 | Other cannabinoids | Open study | Significant pain relief with palmitoylethanolamide (PEA) | ||||||
| Show | Epilepsy | Parental reporting of response to oral cannabis extracts for treatment of refractory epilepsy | Press CA, Knupp KG, Chapman KE | 2015 | Cannabis | Open study | About one third of children suffering from different forms of epilepsy experienced a more than 50 % reduction in seizures by the use of oral cannabis extracts. | ||||||
| Show | Pain | Patient Perceptions of the Use of Medical Marijuana in the Treatment of Pain After Musculoskeletal Trauma: A Survey of Patients at 2 Trauma Centers in Massachusetts | Heng, Marilyn et al. | 2017 | Cannabis;Other cannabinoids | Survey | Trauma patients find relief from a treatment with cannabis according to a survey | ||||||
| Show | Pain | Patient Perceptions of the Use of Medical Marijuana in the Treatment of Pain After Musculoskeletal Trauma: A Survey of Patients at 2 Trauma Centers in Massachusetts. | Heng M, McTague MF, Lucas RC, Harris MB, Vrahas MS, Weaver MJ | 2018 | Cannabis | Survey | Patients believe that medical marijuana is a valid treatment and that it does have a role in reducing postinjury and postoperative pain. | ||||||
| Show | Patient-Reported Symptom Relief Following Medical Cannabis Consumption | Stith SS, Vigil JM, Brockelman F, Keeling K, Hall B. | 2018 | Cannabis | Open study | Cannabis provides symptom relief in a wide range of health conditions | |||||||
| Show | Pain | Patterns and correlates of medical cannabis use for pain among patients prescribed long-term opioid therapy | Nugent SM et al. | 2018 | Cannabis | Survey | Cannabis use in pain patients was associated with a higher risk for opioid misuse | ||||||
| Show | Appetite loss/weight loss;HIV/AIDS;Pain;Depression | Patterns of marijuana use among patients with HIV/AIDS followed in a public health care setting. | Prentiss D, Power R, Balmas G, Tzuang G, Israelski DM. | 2004 | Cannabis | Survey | Improvement of pain, appetite and depression/anxiety by using cannabis | ||||||
| Show | Pain | Patterns of medicinal cannabis use, strain analysis, and substitution effect among patients with migraine, headache, arthritis, and chronic pain in a medicinal cannabis cohort. | Baron EP, Lucas P, Eades J, Hogue O | 2018 | Cannabis | Open study | Pain patients often substitute opioids with cannabis | ||||||
| Show | Cancer | Patterns of Use of Medical Cannabis Among Israeli Cancer Patients: A Single Institution Experience. | Waissengrin B, Urban D, Leshem Y, Garty M, Wolf I. | 2015 | Cannabis | Open study | Cannabis use “is perceived as highly effective” by some patients with advanced cancer. | ||||||
| Show | Pain | Perioperative Patient Beliefs Regarding Potential Effectiveness of Marijuana (Cannabinoids) for Treatment of Pain: A Prospective Population Survey | Khelemsky Y et al. | 2017 | Cannabis | Survey | More than 80% of patients believe that cannabis may reduce pain | ||||||
| Show | Diarrhoea;Gastrointestinal disorder | Pharmacogenetic Trial of a Cannabinoid Agonist Shows Reduced Fasting Colonic Motility in Patients with Non-Constipated Irritable Bowel Syndrome. | Wong BS, Camilleri M, Busciglio I, Carlson P, Szarka LA, Burton D, Zinsmeister AR. | 2011 | Delta-9-THC | Controlled study | Dronabinol reduces fasting motility of the colon in IBS patients with diarrhoea | ||||||
| Show | Epilepsy | Pharmacokinetics and Tolerability of Multiple Doses of Pharmaceutical-Grade Synthetic Cannabidiol in Pediatric Patients with Treatment-Resistant Epilepsy. | Wheless JW, et al. | 2019 | Cannabidiol | Controlled study | CBD may influence the blood concentrations of antiepileptic drugs | ||||||
| Show | Sleep disorder | Pharmacotherapy of Apnea by Cannabimimetic Enhancement, the PACE Clinical Trial: Effects of Dronabinol in Obstructive Sleep Apnea | Carley DW et al. | 2018 | Other cannabinoids | Controlled study | THC may be effective in the treatment of sleep apnoea according to a clinical study | ||||||
| Show | Cancer chemotherapy;Glaucoma | Physiologic observations in a controlled clinical trial of the antiemetic effectiveness of 5, 10, and 15 mg of delta 9-tetrahydrocannabinol in cancer chemotherapy. Ophthalmologic implications. | Levitt M, Wilson A, Bowman D, Kemel S, Krepart G, Marks V, Schipper H, Thomson G, Weinerman B, Weinerman R | 1981 | Delta-9-THC | Controlled study | Patients were remarkably free of adverse physiologic effects. | ||||||
| Show | Pain | Pills to pot: observational analyses of cannabis substitution among medical cannabis users with chronic pain. | Boehnke KF, Scott JR, Litinas E, Sisley S, Williams DA, Clauw DJ. | 2019 | Cannabis | Open study | Cannabis may be an effective pain reliever and substitute for opioids according to a survey | ||||||
| Show | Plasma anandamide concentrations are lower in children with autism spectrum disorder | Karhson DS et al. | 2018 | Open study | In patients with autism there are low blood concentrations of anandamide | ||||||||
| Show | Inflammation | Potent immunomodulatory activity of a highly selective cannabinoid CB2 agonist on immune cells from healthy subjects and patients with multiple sclerosis | Annunziata P, Cioni C, Mugnaini C, Corelli F | 2017 | Open study | Activation of the CB2 receptor counteracts inflammation of nerve cells | |||||||
| Show | Pain | Preliminary assessment of the efficacy, tolerability and safety of a cannabis-based medicine (Sativex) in the treatment of pain caused by rheumatoid arthritis. | Blake DR, Robson P, Ho M, Jubb RW, McCabe CS. | 2006 | Cannabis | Controlled study | Cannabis produced improvements in pain and sleep | ||||||
| Show | Nausea/vomiting;Cancer;Cancer chemotherapy | Preliminary efficacy and safety of an oromucosal standardized cannabis extract in chemotherapy-induced nausea and vomiting. | Duran M, Pérez E, Abanades S, Vidal X, Saura C, Majem M, Arriola E, Rabanal M, Pastor A, Farré M, Rams N, Laporte JR, Capellà D. | 2010 | Cannabis | Controlled study | Cannabis was superior to placebo in reducing nausea and vomiting in patients refractory to other medications | ||||||
| Show | Pain | Preliminary evaluation of the efficacy, safety, and costs associated with the treatment of chronic pain with medical cannabis. | Bellnier T, Brown GW, Ortega TR. | 2018 | Cannabis | Open study | Cannabis reduces pain and increases the quality of life in pain patients | ||||||
| Show | Tourette's syndrome | Preliminary Evidence on Cannabis Effectiveness and Tolerability for Adults With Tourette Syndrome | Abi-Jaoude E, Chen L, Cheung P, Bhikram T, Sandor P | 2017 | Cannabis | Uncontrolled case report | Cannabis effective in Tourette syndrome in case series | ||||||
| Show | Tourette's syndrome | Preliminary Evidence on Cannabis Effectiveness and Tolerability for Adults With Tourette Syndrome | Abi-Jaoude E, Chen L, Cheung P, Bhikram T, Sandor P | 2017 | Cannabis | Open study | Cannabis improved symptoms of Tourette syndrome | ||||||
| Show | Preliminary observation with dronabinol in patients with intractable pruritus secondary to cholestatic liver disease. | Neff GW, O'Brien CB, Reddy KR, Bergasa NV, Regev A, Molina E, Amaro R, Rodriguez MJ, Chase V, Jeffers L, Schiff E. | 2002 | Delta-9-THC | Open study | THC signficantly reduced intractable cholestatic related pruritus | |||||||
| Show | Preliminary results from a pilot study examining brain structure in older adult cannabis users and nonusers. | Thayer RE, YorkWilliams SL, Hutchison KE, Bryan AD. | 2019 | Cannabis | Open study | Cannabis use has no relevant effect on the brain on adults | |||||||
| Show | Prescription of a THC/CBD-Based Medication to Patients with Dementia: A Pilot Study in Geneva | Broers B., Patà Z., Mina A., Wampfler J., de Saussure C., Pautex S. | 2019 | Cannabis | Open study | Cannabis may improve behaviour in patients with dementia according to observational study | |||||||
| Show | Nausea/vomiting | Prevention of nausea and vomiting following breast surgery. | Layeeque R, Siegel E, Kass R, Henry-Tillman RS, Colvert M, Mancino A, Klimberg VS. | 2006 | Delta-9-THC | Open study | Postoperative nausea and vomiting was reduced by prophylactic administration of dronabinol and prochlorperazine | ||||||
| Show | Prior Cannabis Use Is Associated with Outcome after Intracerebral Hemorrhage. | Di Napoli M, Zha AM, Godoy DA, Masotti L, Schreuder FH, Popa-Wagner A, Behrouz R; MNEMONICH Registry. | 2016 | Cannabis | Open study | Cannabinoids-positive patients had lower median disease scores on admission | |||||||
| Show | Profiles of medicinal cannabis patients attending compassion centers in rhode island. | Zaller N, Topletz A, Frater S, Yates G, Lally M. | 2015 | Cannabis | Survey | Most participants report that medicinal cannabis improves their pain symptomology. | |||||||
| Show | Prolonged Cannabidiol Treatment Effects on Hippocampal Subfield Volumes in Current Cannabis Users | Beale C et al. | 2018 | Cannabis | Open study | CBD repaired negative effects of regular cannabis use on a certain brain region | |||||||
| Show | Prolonged cannabis withdrawal in young adults with lifetime psychiatric illness. | Schuster RM, Fontaine M, Nip E, Zhang H, Hanly A, Evins AE | 2017 | Cannabis | Survey | Prolonged withdrawal symptoms in young cannabis users with psychiatric diseases | |||||||
| Show | Spasticity | Proof of concept trial of dronabinol in obstructive sleep apnea. | Prasad B, Radulovacki MG, Carley DW. | 2013 | Delta-9-THC | Open study | THC significantly improved this condition. | ||||||
| Show | Cancer | Prospective analysis of safety and efficacy of medical cannabis in large unselected population of patients with cancer | Bar-Lev Schleider L et al. | 2018 | Cannabis | Open study | Cannabis is effective in alleviating symptoms of cancer patients | ||||||
| Show | Nausea/vomiting;Cancer;Cancer chemotherapy | Prospective randomized double-blind trial of nabilone versus domperidone in the treatment of cytotoxic-induced emesis. | Pomeroy M, Fennelly JJ, Towers M. | 1986 | Nabilone | Controlled study | Nabilone superior to domperidone | ||||||
| Show | Multiple sclerosis | Psychopathological and cognitive effects of therapeutic cannabinoids in multiple sclerosis: a double-blind, placebo controlled, crossover study. | Aragona M, Onesti E, Tomassini V, Conte A, Gupta S, Gilio F, Pantano P, Pozzilli C, Inghilleri M. | 2009 | Cannabis | Controlled study | Cannabis did not impair cognition | ||||||
| Show | PTSD contributes to teen and young adult cannabis use disorders. | Cornelius JR, Kirisci L, Reynolds M, Clark DB, Hayes J, Tarter R. | 2010 | Cannabis | Survey | People with PTSD have a higher risk for cannabis use | |||||||
| Show | Tourette's syndrome | Pure delta-9-tetrahydrocannabinol and its combination with cannabidiol in treatment-resistant Tourette syndrome: A case report. | Pichler EM, Kawohl W, Seifritz E, Roser P. | 2018 | Delta-9-THC;Cannabidiol | Uncontrolled case report | A case report suggests that CBD may be beneficial in Tourette syndrome | ||||||
| Show | Pain | Qualifying Conditions Of Medical Cannabis License Holders In The United States. | Boehnke KF, Gangopadhyay S, Clauw DJ, Haffajee RL. | 2019 | Cannabis | Open study | Chronic pain is the main reason for the medical use of cannabis in the USA | ||||||
| Show | Nausea/vomiting | Randomised clinical trial of levonantradol and chlorpromazine in the prevention of radiotherapy-induced vomiting. | Lucraft HH, Palmer MK | 1982 | Other cannabinoids | Controlled study | The frequency of vomiting was similar after levonantradol and chlorpromazine. | ||||||
| Show | Randomised clinical trial: the analgesic properties of dietary supplementation with palmitoylethanolamide and polydatin in irritable bowel syndrome | Cremon C et el. | 2017 | Controlled study | A treatment with palmithoylethanolamide and polydatin improved pain in irritable bowel syndrome | ||||||||
| Show | Multiple sclerosis | Randomised controlled study of cannabis-based medicine (Sativex®) in patients suffering from multiple sclerosis associated detrusor overactivity | de Ridder D, Constantinescu CS,Fowler C, Kavia R, Sarantis N. | 2006 | Cannabis | Controlled study | A significant reduction in the number of voids per day and during the night. | ||||||
| Show | Multiple sclerosis;Pain | Randomised controlled trial of cannabis based medicinal extracts (CBME) in central neuropathic pain due to multiple sclerosis. | Young CA, Rog DJ | 2003 | Cannabis | Controlled study | Significant reduction in pain | ||||||
| Show | Multiple sclerosis | Randomised controlled trial of cannabis based medicine (CBM, Stativex®) to treat detrusor overactivity in multiple sclerosis. | Kavia R, De Ridder D, Sarantis N, Constantinescu C, Fowler. | 2000 | Cannabis | Controlled study | There was no effect on daily incontinence, but the cannabis extract was superior to placebo for nocturia. | ||||||
| Show | Pain | Randomised Placebo Controlled Double Blind Clinical Trial of Cannabis Based Medicinal Product (Sativex) in Painful Diabetic Neuropathy: Depression is a Major Confounding Factor. | Selvarajah D, Gandhi R, Emery CJ, Tesfaye S. | 2010 | Cannabis | Controlled study | No difference between cannabis extract and placebo. | ||||||
| Show | Dystonia | Randomised, double-blind, placebo-controlled trial to assess the potential of cannabinoid receptor stimulation in the treatment of dystonia. | Fox SH, Kellett M, Moore AP, Crossman AR, Brotchie JM | 2002 | Nabilone | Controlled study | No significant reduction in dystonia following treatment with nabilone | ||||||
| Show | Spasticity;Multiple sclerosis | Randomized controlled trial of cannabis-based medicine in spasticity caused by multiple sclerosis | Collin C, Davies P, Mutiboko IK, Ratcliffe S, for the Sativex Spasticity in MS Study Group | 2007 | Cannabis | Controlled study | Significantly reduction in spasticity | ||||||
| Show | Multiple sclerosis | Randomized controlled trial of Sativex to treat detrusor overactivity in multiple sclerosis. | Kavia RB, De Ridder D, Constantinescu CS, Stott CG, Fowler CJ. | 2010 | Cannabis | Controlled study | The cannabis extract had some effect on overactive bladder symptoms. | ||||||
| Show | Nausea/vomiting;Cancer;Cancer chemotherapy | Randomized double blind comparison of delta-9-tetrahydroicannabinol (THC) and marijuana as chemotherapy antiemetics. | Levitt M, Faiman C, Hawks R, Wilson A | 1984 | Cannabis;Delta-9-THC | Controlled study | 9 patients no preference; 7 preferred oral THC, 4 preferred marijuana cigarettes (double-blind, double dummy crossover study) | ||||||
| Show | Diarrhoea;Gastrointestinal disorder | Randomized pharmacodynamic and pharmacogenetic trial of dronabinol effects on colon transit in irritable bowel syndrome-diarrhea | Wong BS, Camilleri M, Eckert D, Carlson P, Ryks M, Burton D, Zinsmeister AR | 2012 | Delta-9-THC | Controlled study | THC had no significant effects on gut transit. | ||||||
| Show | Multiple sclerosis;Pain | Randomized, controlled trial of cannabis-based medicine in central pain in multiple sclerosis. | Rog DJ, Nurmikko TJ, Friede T, Young CA. | 2005 | Cannabis | Controlled study | Cannabis is effective in reducing pain and sleep disturbance in patients with multiple sclerosis related central neuropathic pain | ||||||
| Show | Rare diseases | Randomized, dose-ranging safety trial of cannabidiol in Dravet syndrome | Devinsky O. et al. | 2018 | Cannabidiol | Controlled study | The use of CBD in children has only minimal effects on other antiepileptic drugs | ||||||
| Show | Appetite loss/weight loss;HIV/AIDS | Recent clinical experience with dronabinol. | Plasse TF, Gorter RW, Krasnow SH, Lane M, Shepard KV, Wadleigh RG | 1991 | Delta-9-THC | Open study | Significant weight gain | ||||||
| Show | Recreational marijuana legalization and prescription opioids received by Medicaid enrollees. | Shi Y, Liang D, Bao Y, An R, Wallace MS, Grant I. | 2019 | Open study | Legalisation of cannabis for adult use is associated with reduced opioid use in the USA | ||||||||
| Show | Reduced Incidence and Better Liver Disease Outcomes among Chronic HCV Infected Patients Who Consume Cannabis | Adejumo AC, Adegbala OM, Adejumo KL, Bukong TN. | 2018 | Cannabis | Open study | Cannabis reduces risk of liver cirrhosis in patients with hepatitis C virus infection | |||||||
| Show | Reduced Prevalence of Alcoholic Gastritis in Hospitalized Individuals Who Consume Cannabis | Adejumo AC, Li J, Akanbi O, Adejumo KL, Bukong TN. | 2018 | Cannabis | Open study | Cannabis reduces the risk for alcohol-associated gastritis | |||||||
| Show | Reduced Risk of Alcohol-Induced Pancreatitis With Cannabis Use. | Adejumo AC, Akanbi O, Adejumo KL, Bukong TN. | 2018 | Cannabis | Open study | Cannabis use is associated with a reduced risk for alcohol-associated pancreatitis | |||||||
| Show | Pain | Reduction of Benzodiazepine Use in Patients Prescribed Medical Cannabis | Purcell C.,Davis A., Moolman N.,Taylor S.N. | 2019 | Cannabis | Open study | Medical cannabis users reduce their intake of benzodiazepines | ||||||
| Show | Obsessive compulsive disorder | Refractory OCD Due to Thalamic Infarct With Response to Dronabinol | Cooper JJ, Grant J | 2017 | Delta-9-THC | Uncontrolled case report | |||||||
| Show | Relation of Cannabis Use and Atrial Fibrillation Among Patients Hospitalized for Heart Failure | Adegbala O et al. | 2018 | Cannabis | Open study | Cannabis use was associated with a lower risk of artrial fibrillation | |||||||
| Show | Cancer | Relationship of Cannabis Use to Patient-Reported Symptoms in Cancer Patients Seeking Supportive/Palliative Care. | Donovan KA, et al. | 2019 | Cannabis | Open study | Many cancer patients treated themselves with cannabis | ||||||
| Show | Relief oriented use of marijuana by teens. | Bottorff JL, Johnson JL, Moffat BM, Mulvogue T. | 2009 | Cannabis | Survey | 20 participants said that they used cannabis to treat health problems. | |||||||
| Show | Posttraumatic stress disorder | Remission of severe, treatment-resistant schizophrenia following adjunctive cannabidiol | Makiol C., Kluge M. | 2018 | Cannabidiol | Uncontrolled case report | CBD effective in treatment-resistant schizophrenia according to a case report | ||||||
| Show | Epilepsy | Report from a Survey of Parents Regarding the Use of Cannabidiol (Medicinal cannabis) in Mexican Children with Refractory Epilepsy | Aguirre-Velázquez CG | 2017 | Cannabis | Survey;Basic research | CBD-rich cannabis reduced seizures in children with epilepsy according to a survey | ||||||
| Show | Cancer | Report of Objective Clinical Responses of Cancer Patients to Pharmaceutical-grade Synthetic Cannabidiol | Kenyon J, Liu W, Dalgleish A. | 2018 | Cannabidiol | Open study | Cannabidiol may be useful in the treatment of cancer according to an observational study | ||||||
| Show | Spasticity;Pain | Reposition of a dislocated shoulder under use of cannabis. | Schweizer A, Bircher HP. | 2009 | Cannabis | Uncontrolled case report | Pain and muscular tone decreased and the shoulder was relocated easily. | ||||||
| Show | Cancer;Pain | Results of a Double-Blind, Randomized, Placebo-Controlled Study of Nabiximols Oromucosal Spray as an Adjunctive Therapy in Advanced Cancer Patients with Chronic Uncontrolled Pain | Lichtman AH et al. | 2018 | Other cannabinoids | Low effects of a cannabis extract in cancer patients in a large controlled study | |||||||
| Show | Appetite loss/weight loss;Alzheimer's disease | Safety and efficacy of dronabinol in the treatment of agitation in patients with Alzheimer’s disease with anorexia: A retrospective chart review | Patel S, Shua-Haim JR, Pass M | 2003 | Delta-9-THC | Open study | Weight gain in all, reduction of agitation in 65%. | ||||||
| Show | Alzheimer's disease | Safety and Efficacy of Medical Cannabis Oil for Behavioral and Psychological Symptoms of Dementia: An-Open Label, Add-On, Pilot Study. | Shelef A, Barak Y, Berger U, Paleacu D, Tadger S, Plopsky I, Baruch Y. | 2016 | Cannabis | Open study | Following aspects significantly decreased: Delusions, agitation/aggression, irritability, apathy, and sleep and caregiver distress | ||||||
| Show | Cancer chemotherapy | Safety and efficacy of nabilone for acute chemotherapy-induced vomiting prophylaxis in pediatric patients: A multicenter, retrospective review. | Polito S, MacDonald T, Romanick M, Jupp J, Wiernikowski J, Vennettilli A, Khanna M, Patel P, Ning W, Sung L, Dupuis LL. | 2018 | Delta-9-THC | Open study | Nabilone is well tolerated in children undergoing chemotherapy | ||||||
| Show | Amyotrophic lateral sclerosis;Spasticity | Safety and efficacy of nabiximols on spasticity symptoms in patients with motor neuron disease (CANALS): a multicentre, double-blind, randomised, placebo-controlled, phase 2 trial. | Riva N. et al. | 2018 | Controlled study | Cannabis is effective in spasticity due to amyotrophic lateral sclerosis | |||||||
| Show | Safety and pharmacokinetics of oral delta-9-tetrahydrocannabinol in healthy older subjects: A randomized controlled trial. | Ahmed AI, van den Elsen GA, Colbers A, van der Marck MA, Burger DM, Feuth TB, Rikkert MG, Kramers C. | 2014 | Delta-9-THC | Controlled study | THC appeared to be safe and well tolerated by healthy older individuals. | |||||||
| Show | Dependency/withdrawal | Safety of oral dronabinol during opioid withdrawal in humans | Jicha CJ, Lofwall MR, Nuzzo PA, Babalonis S, Elayi SC, Walsh SL. | 2015 | Delta-9-THC | Controlled study | 40 mg of THC caused increased heart rate and anxiety, which made dose-reduction necessary | ||||||
| Show | Spasticity;Multiple sclerosis | Safety, tolerability, and efficacy of orally administered cannabinoids in MS. | Killestein J, Hoogervorst EL, Reif M, Kalkers NF, Van Loenen AC, Staats PG, Gorter RW, Uitdehaag BM, Polman CH | 2002 | Cannabis;Delta-9-THC | Controlled study | Compared with placebo, neither THC nor plant-extract treatment reduced spasticity. | ||||||
| Show | Cancer;Pain | Sativex oromucosal spray as adjunctive therapy in advanced cancer patients with chronic pain unalleviated by optimized opioid therapy: two double-blind, randomized, placebo-controlled phase 3 studies. | Fallon MT et al. | 2017 | Cannabidiol;Other cannabinoids | Controlled study | A cannabis extract did not reduce pain in advanced cancer patients, who did not respond to opioids | ||||||
| Show | Pain | Sativex successfully treats neuropathic pain characterised by allodynia: A randomised, double-blind, placebo-controlled clinical trial. | Nurmikko TJ, Serpell MG, Hoggart B, Toomey PJ, Morlion BJ, Haines D. | 2007 | Cannabis | Controlled study | Significant improvement in pain by cannabis | ||||||
| Show | Multiple sclerosis | Sativex® as Add-on therapy Vs. further optimized first-line ANTispastics (SAVANT) in resistant multiple sclerosis spasticity: a double-blind, placebo-controlled randomised clinical trial. | Markovà J, Essner U, Akmaz B, Marinelli M, Trompke C, Lentschat A, Silván CV | 2018 | Other cannabinoids | Controlled study | Long-term efficacy of a cannabis spray in the treatment of spasticity due to multiple sclerosis | ||||||
| Show | Spasticity;Spinal cord injury;Pain | Sativex® in the Treatment of Central Neuropathic Pain due to Spinal Cord Injury: A Randomised Controlled Study | Berman J & the Sativex Spinal Cord Injury Study Group, Bosworth T2 Guy G & Stott C. | 2007 | Cannabis | Controlled study | primary outcome mean NRS 11 poitn pain scale - nod difference - BPI secondary ourcome benefit - significant at p<0.032 | ||||||
| Show | Epilepsy | Seizure exacerbation in two patients with focal epilepsy following marijuana cessation. | Hegde M, Santos-Sanchez C, Hess CP, Kabir AA, Garcia PA. | 2012 | Cannabis | Uncontrolled case report | Patients with epilepsy were able to control their seizures by the use of cannabis. | ||||||
| Show | Self-initiated use of topical cannabidiol oil for epidermolysis bullosa | Chelliah MP, Zinn Z, Khuu P, Teng JMC | 2018 | Cannabidiol | |||||||||
| Show | Self-management strategies amongst Australian women with endometriosis: a national online survey. | Armour M, Sinclair J, Chalmers KJ, Smith CA. | 2019 | Cannabis | Survey | Cannabis may be highly effective in the self-management of endometriosis according to survey | |||||||
| Show | Pain | Self-Reported Effectiveness and Safety of Trokie® Lozenges: A Standardized Formulation for the Buccal Delivery of Cannabis Extracts. | Crowley K, de Vries ST, Moreno-Sanz G. | 2018 | Cannabis | Open study | Cannabis lozenges reduce pain in an observational study | ||||||
| Show | Separate and combined effects of the cannabinoid agonists nabilone and Δ(9)-THC in humans discriminating Δ(9)-THC. | Lile JA, Kelly TH, Hays LR. | 2011 | Delta-9-THC;Nabilone | Controlled study | THC caused similar effects as nabilone | |||||||
| Show | Depression | Serum Endocannabinoid and Mood Changes after Exercise in Major Depressive Disorder. | Meyer JD, Crombie KM, Cook DB, Hillard CJ, Koltyn KF. | 2019 | Controlled study | Endocannabinoids contribute to the mood improving effects of exercise in patients with major depression | |||||||
| Show | Dependency/withdrawal;Depression | Sex Differences in the Association Between Cannabis Use and Suicidal Ideation and Attempts, Depression, and Psychological Distress Among Canadians. | Halladay JE, Boyle MH, Munn C, Jack SM, Georgiades K. | 2018 | Cannabis | Open study | Cannabis use may be associated with an increased risk of suicide | ||||||
| Show | HIV/AIDS | Short-term effects of cannabinoids in patients with HIV-1 infection: a randomized, placebo-controlled clinical trial. | Abrams DI, Hilton JF, Leiser RJ, Shade SB, Elbeik TA, Aweeka FT, Benowitz NL, Bredt BM, Kosel B, Aberg JA, Deeks SG, Mitchell TF, Mulligan K, Bacchetti P, McCune JM, Schambelan M | 2003 | Cannabis;Delta-9-THC | Controlled study | Cannabis and THC had no significant effect on HI virus load and on CD4+ and CD8+ cell count | ||||||
| Show | Multiple sclerosis | Short-term effects of smoking marijuana on balance in patients with multiple sclerosis and normal volunteers | Greenberg HS, Werness SAS, Pugh JE, Andrus RO, Anderson DJ, Domino EF | 1994 | Cannabis | Controlled study | Cannabis reduced posture and balance in patients with MS | ||||||
| Show | Should donors who have used marijuana be considered candidates for living kidney donation? | Ruckle, D. et al. | 2018 | Cannabis | Open study | Cannabis users may be kidney donors | |||||||
| Show | Tourette's syndrome | Single center experience with medical cannabis in Gilles de la Tourette syndrome | Thaler A, Arad S, Schleider LB, Knaani J, Taichman T, Giladi N, Gurevich T. | 2018 | Cannabis | Open study | Cannabis is effective in Tourette syndrome according to a survey | ||||||
| Show | Pain | Single dose delta-9-tetrahydrocannabinol in chronic pancreatitis patients: analgesic efficacy, pharmacokinetics and tolerability | de Vries M, van Rijckevorsel DC, Vissers KC, Wilder-Smith OH, van Goor H(; Pain and Nociception Neuroscience Research Group | 2015 | Delta-9-THC | Controlled study | No effect of a single low dose of THC on abdominal pain resulting from chronic pancreatitis in clinical study. | ||||||
| Show | Anxiety | Single-dose study of nabilone in anxious volunteers. | Glass RM, Uhlenhuth EH, Hartel FW, Schuster CR, Fischman MW. | 1981 | Nabilone | Controlled study | Antianxiety effects in 2 of the 8 subjects | ||||||
| Show | Pain | Smoked cannabis for chronic neuropathic pain: a randomized controlled trial. | Ware MA, Wang T, Shapiro S, Robinson A, Ducruet T, Huynh T, Gamsa A, Bennett GJ, Collet JP. | 2010 | Cannabis | Controlled study | Cannabis improved pain and sleep quality. | ||||||
| Show | Multiple sclerosis;Pain;Spasticity | Smoked cannabis for spasticity in multiple sclerosis: a randomized, placebo-controlled trial. | Corey-Bloom J, Wolfson T, Gamst A, Jin S, Marcotte TD, Bentley H, Gouaux B. | 2012 | Cannabis | Controlled study | Smoked cannabis was superior to placebo in reducing spasticity and pain. | ||||||
| Show | HIV/AIDS;Pain | Smoked cannabis therapy for HIV-related painful peripheral neuropathy: results of a randomized, placebo-controlled clinical trial. | Abrams DI, Jay CA, Vizoso H, Shade SB, Reda H, Press S, Kelly ME, Rowbotham M, Petersen K | 2005 | Cannabis | Controlled study | Smoked cannabis is effective in reducing HIV-related neuropathic pain | ||||||
| Show | Smoked marijuana attenuates performance and mood disruptions during simulated night shift work | Keith DR, Gunderson EW, Haney M, Foltin RW, Hart CL | 2017 | Cannabis | Open study | The use of cannabis improves performance during simulated night shift work | |||||||
| Show | HIV/AIDS;Pain | Smoked medicinal cannabis for neuropathic pain in HIV: a randomized, crossover clinical trial. | Ellis RJ, Toperoff W, Vaida F, van den Brande G, Gonzales J, Gouaux B, Bentley H, Atkinson JH. | 2009 | Cannabis | Controlled study | Significant pain relief with cannabis. | ||||||
| Show | Smoking and Diabetes Mellitus: Results from Meta-analysis with Eight Independent Replication Samples | Alshaarawy O, Anthony JC. | 2015 | Cannabis | Survey | Cannabis use was associated with a 30% reduction of diabetes risk | |||||||
| Show | Tourette's syndrome | Speechlessness in Gilles de la Tourette Syndrome: Cannabis-Based Medicines Improve Severe Vocal Blocking Tics in Two Patients | Jakubovski E, Müller-Vahl K | 2017 | Cannabis;Delta-9-THC | Uncontrolled case report | Speechlessness in Tourette syndrome may be treated with cannabis/THC according to case reports | ||||||
| Show | Cancer | Spontaneous regression of septum pellucidum/forniceal pilocytic astrocytomas-possible role of Cannabis inhalation. | Foroughi M, Hendson G, Sargent MA, Steinbok P. | 2011 | Cannabis | Uncontrolled case report | Spontaneous regression of benign brain tumour may have been associated with cannabis use. | ||||||
| Show | Spontaneous, anecdotal, retrospective, open-label study on the efficacy, safety and tolerability of cannabis galenical preparation (Bedrocan). | Palmieri B, Laurino C, Vadalà M. | 2019 | Cannabis | Open study | An oral preparation of Bedrocan cannabis showed significant improvement in several chronic diseases | |||||||
| Show | Pain | Standardized cannabis extract in the treatment of postherpetic neuralgia – a randomized, double-blind, placebo-controlled cross-over study. | Ernst G, Denke C, Reif M, Schnelle M, Hagmeister H | 2005 | Cannabis | Controlled study | Cannabis did not reduce pain | ||||||
| Show | Cancer | Striking lung cancer response to self-administration of cannabidiol: A case report and literature review. | Sulé-Suso J, Watson NA, van Pittius DG, Jegannathen A. | 2019 | Cannabidiol | Uncontrolled case report | CBD and a strong effect on a patient with lung cancer | ||||||
| Show | Subjective aggression during alcohol and cannabis intoxication before and after aggression exposure. | De Sousa Fernandes Perna EB, Theunissen EL, Kuypers KP, Toennes SW, Ramaekers JG. | 2016 | Cannabis | Subjective aggression significantly increased following aggression exposure in all groups while being sober. | ||||||||
| Show | Subjective and Physiological Effects After Controlled Sativex and Oral THC Administration. | Karschner EL, Darwin WD, McMahon RP, Liu F, Wright S, Goodwin RS, Huestis MA. | 2011 | Cannabis;Delta-9-THC;Cannabidiol | Controlled study | Oral THC and the cannabis extract Sativex produced similar effects | |||||||
| Show | Subregional Hippocampal Thickness Abnormalities in Older Adults with a History of Heavy Cannabis Use. | Burggren AC. et al. | 2018 | Cannabis | Open study | Cannabis users have lower cortical thickness of the hippocampus in the brain | |||||||
| Show | Anxiety;Pain;Sleep disorder | Substitution of medical cannabis for pharmaceutical agents for pain, anxiety, and sleep | Piper BJ et al. | 2018 | Cannabis | Survey | Patients who use cannabis reduce their use in medications for pain, anxiety, migraine and sleep disorders | ||||||
| Show | Epilepsy | Successful use of pure cannabidiol for the treatment of super-refractory status epilepticus. | Rajaraman RR, Sankar R, Hussain SA. | 2018 | Cannabidiol | Uncontrolled case report | CBD may be effective in refractory status epilepticus according to a case report | ||||||
| Show | Nausea/vomiting;Cancer;Cancer chemotherapy | Superiority of nabilone over prochlorperazine as an antiemetic in patients receiving cancer chemotherapy. | Herman TS, Einhorn LH, Jones SE, Nagy C, Chester AB, Dean JC, Furnas B, Williams SD, Leigh SA, Dorr RT, Moon TE. | 1979 | Nabilone | Controlled study | When both drugs were compared, both nausea and vomiting episodes were significantly lower in patients given nabilone. | ||||||
| Show | Appetite loss/weight loss;Spasticity;Pain;Depression | Survey of cannabis use in patients with amyotrophic lateral sclerosis. | Amtmann D, Weydt P, Johnson KL, Jensen MP, Carter GT. | 2004 | Cannabis | Survey | Moderate improvement of pain, spasticity, appetite and depression | ||||||
| Show | Nausea/vomiting | Survey of medicinal cannabis use among childbearing women: patterns of its use in pregnancy and retroactive self-assessment of its efficacy against 'morning sickness'. | Westfall RE, Janssen PA, Lucas P, Capler R. | 2006 | Cannabis | Survey | Cannabis effective against nausea and vomiting | ||||||
| Show | Parkinson's disease | Survey on cannabis use in Parkinson's disease: subjective improvement of motor symptoms. | Venderova K, Ruzicka E, Vorisek V, Visnovsky P. | 2004 | Cannabis | Survey | 25% of the respondents had taken cannabis and 45.9% of these described some form of benefit. | ||||||
| Show | Survey on the medical use of cannabis and THC in Germany. | Grotenhermen F, Schnelle M. | 2003 | Cannabis;Delta-9-THC | Survey | Cannabis and THC were effective in many conditions | |||||||
| Show | Pain | Synergistic affective analgesic interaction between delta-9-tetrahydrocannabinol and morphine. | Roberts JD, Gennings C, Shih M. | 2006 | Delta-9-THC | Controlled study | There was a synergistic effect between THC and morphine on the affective component of pain but not on the sensory component | ||||||
| Show | Synthetic delta-9-tetrahydrocannabinol (dronabinol) can improve the symptoms of schizophrenia. | Schwarcz G, Karajgi B, McCarthy R. | 2009 | Cannabis | Open study | Improvement in 4 of 6 participants, of whom 3 showed a significant improvement. | |||||||
| Show | Dystonia | Tardive Dystonia and the Use of Cannabis. | Beckmann Y, Seçil Y, Güngör B, Yiğit T. | 2010 | Cannabis;Delta-9-THC | Uncontrolled case report | Significant improvement by cannabis and dronabinol. | ||||||
| Show | Testing associations between cannabis use and subcortical volumes in two large population-based samples | Gillespie NA et al. | 2018 | Open study | Cannabis use has no effect on brain structure | ||||||||
| Show | Spasticity | Tetrahydrocannabinol (THC) for cramps in amyotrophic lateral sclerosis: a randomised, double-blind crossover trial. | Weber M, Goldman B, Truniger S. | 2010 | Delta-9-THC | Controlled study | There were no effects on cramp intensity, number of cramps and fasciculation intensity. | ||||||
| Show | Pain | Tetrahydrocannabinol Does not Reduce Pain in Patients With Chronic Abdominal Pain in a Phase 2 Placebo-controlled Study. | de Vries M, van Rijckevorsel DC, Vissers KC, Wilder-Smith OH, van Goor H; Pain and Nociception Neuroscience Research Group. | 0000 | Delta-9-THC | Controlled study | No effect of THC on pain in patients with abdominal pain | ||||||
| Show | Alzheimer's disease | Tetrahydrocannabinol for neuropsychiatric symptoms in dementia: A randomized controlled trial. | van den Elsen GA, Ahmed AI, Verkes RJ, Kramers C, Feuth T, Rosenberg PB, van der Marck MA, Olde Rikkert MG. | 2015 | Delta-9-THC | Controlled study | No reduction in NPS by low-dose THC (3x1.5mg), though it is well-tolerated | ||||||
| Show | Multiple sclerosis; Tremor | Tetrahydrocannabinol for tremor in multiple sclerosis. | Clifford DB | 1983 | Delta-9-THC | Controlled study | 2 patients with objective improvement, 5 with subjective improvement | ||||||
| Show | Nausea/vomiting;Cancer | Tetrahydrocannabinol vs. prochlorperazine. The effects of two antiemetics on patients undergoing radiotherapy. | Ungerleider JT, Andrysiak TA, Fairbanks LA, Tesler AS, Parker RG. | 1984 | Delta-9-THC | Controlled study | THC was slightly superior to prochlorperazine | ||||||
| Show | Multiple sclerosis | Tetrahydrocannabinol/Cannabidiol Oromucosal Spray in Patients With Multiple Sclerosis: A Pilot Study on the Plasma Concentration-Effect Relationship. | Contin M, Mancinelli L, Perrone A, Sabattini L, Mohamed S, Scandellari C, Foschi M, Vacchiano V, Lugaresi A, Riva R. | 2018 | Delta-9-THC;Cannabidiol | Open study | Large variation of plasma concentrations of THC and CBD after oral intake | ||||||
| Show | Nausea/vomiting;Appetite loss/weight loss;HIV/AIDS | THC improves appetite and reverses weight loss in AIDS patients | Dejesus E, Rodwick BM, Bowers D, Cohen CJ, Pearce D | 2007 | Delta-9-THC | Open study | THC improved appetite and weight and reduced nausea | ||||||
| Show | Nausea/vomiting;Cancer;Cancer chemotherapy | THC or Compazine for the cancer chemotherapy patient--the UCLA study. Part II: Patient drug preference. | Ungerleider JT, Sarna G, Fairbanks LA, Goodnight J, Andrysiak T, Jamison K. | 1985 | Delta-9-THC | Controlled study | nausea reduction was the main determinant of preference between THC and prochlorperazine | ||||||
| Show | Multiple sclerosis | THC/CBD oromucosal spray in patients with multiple sclerosis overactive bladder: a pilot prospective study | Maniscalco GT et al. | 2018 | Other cannabinoids | Open study | Cannabis may be beneficial in overactive bladder of patients with MS according to an observational study | ||||||
| Show | Pain | The analgesic effect of oral delta-9-tetrahydrocannabinol (THC), morphine, and a THC-morphine combination in healthy subjects under experimental pain conditions. | Naef M, Curatolo M, Petersen-Felix S, Arendt-Nielsen L, Zbinden A, Brenneisen R. | 2003 | Delta-9-THC | Controlled study | No effect of THC on experimental pain in healthy subjects | ||||||
| Show | Cancer; Pain | The analgesic properties of delta-9-tetrahydrocannabinol and codeine. | Noyes R Jr, Brunk SF, Avery DAH, Canter AC | 1975 | Delta-9-THC | Controlled study | milde analgesic effect; with 20 mg THC strong adverse effects | ||||||
| Show | Nausea/vomiting;Cancer;Cancer chemotherapy | The antiemetic activity of tetrahydrocanabinol versus metoclopramide and thiethylperazine in patients undergoing cancer chemotherapy. | Colls BM, Ferry DG, Gray AJ, Harvey VJ, McQueen EG. | 1980 | Delta-9-THC | Controlled study | tetrahydrocannabinol given by mouth has an antiemetic effect of approximately the same order as thiethylperazine and metoclopramide | ||||||
| Show | The Association between Cannabis Product Characteristics and Symptom Relief. | Stith SS, Vigil JM, Brockelman F, Keeling K, Hall B. | 2019 | Cannabis | Open study | Medicinal effects of cannabis are mainly based on THC and cannabis flowers were most effective | |||||||
| Show | The association between cannabis use and psychiatric comorbidity in people with personality disorders: A population-based longitudinal study. | Shalit N, Rehm J, Lev-Ran S. | 2019 | Open study | Cannabis users with personality disorders are not at increased risk for developing other psychiatric disorders | ||||||||
| Show | Psychosis/schizophrenia | The association between cannabis use and suicidal behavior in patients with psychiatric disorders: an analysis of sex differences | Naji L. et al. | 2018 | Cannabis | Open study | Cannabis use has no effect on suicidal attempts in psychiatric disorders | ||||||
| Show | The Association Between Tetrahydrocannabinol and Lower Urinary Tract Symptoms Utilizing the National Health and Nutrition Examination Survey. | Fantus RJ, Riedinger CB, Chang C, Helfand BT. | 2018 | Delta-9-THC | Survey | Cannabis use is protective against lower urinary tract symptoms | |||||||
| Show | The cannabinoid receptor agonist delta-9-tetrahydrocannabinol does not affect visceral sensitivity to rectal distension in healthy volunteers and IBS patients. | Klooker TK, Leliefeld KE, Van Den Wijngaard RM, Boeckxstaens GE. | 2011 | Delta-9-THC | Controlled study | THC did not modify visceral perception to rectal distension. | |||||||
| Show | Alzheimer's disease | The cannabinoid receptor agonist nabilone for the treatment of dementia-related agitation. | Passmore MJ. | 2008 | Nabilone | Uncontrolled case report | Dramatic reduction in the severity of agitation and other behavioural symptoms | ||||||
| Show | Pain | The Consumption of Cannabis by Fibromyalgia Patients in Israel. | Habib G, Avisar I. | 2018 | Cannabis | Survey | Many patients with fibromyalgia profit from a treatment with cannabis according to survey | ||||||
| Show | Psychosis/schizophrenia | The contribution of cannabis use to variation in the incidence of psychotic disorder across Europe (EU-GEI): a multicentre case-control study. | Di Forti M, et al. | 2019 | Cannabis | Open study | High potency cannabis is associated with a higher risk for psychosis | ||||||
| Show | Dependency/withdrawal | The dose effects of short-term dronabinol (oral THC) maintenance in daily cannabis users. | Vandrey R, Stitzer ML, Mintzer MZ, Huestis MA, Murray JA, Lee D. | 2013 | Delta-9-THC | Open study | THC dose-dependently attenuated cannabis withdrawal. | ||||||
| Show | Multiple sclerosis | The effect of cannabinoids on the stretch reflex in multiple sclerosis spasticity. | Marinelli L, Mori L, Canneva S, Colombano F, Currà A, Fattapposta F, Bandini F, Capello E, Abbruzzese G, Trompetto C. | 2016 | Cannabis | Controlled study | Cannabis reduces the stretch reflex in patients with multiple sclerosis | ||||||
| Show | Multiple sclerosis;Tremor | The effect of cannabis on tremor in patients with multiple sclerosis. | Fox P, Bain PG, Glickman S, Carroll C, Zajicek J. | 2004 | Cannabis;Delta-9-THC;Other cannabinoids | Controlled study | No significant improvement of tremor | ||||||
| Show | Multiple sclerosis | The effect of cannabis on urge incontinence in patients with multiple sclerosis: a multicentre, randomised placebo-controlled trial (CAMS-LUTS). | Freeman RM, Adekanmi O, Waterfield MR, Waterfield AE, Wright D, Zajicek J. | 2006 | Cannabis;Delta-9-THC | Controlled study | Cannabis and dronabinol caused a significant reduction in incontinence | ||||||
| Show | Spasticity | The effect of delta-9-THC on human spasticity. | Hanigan WC, Destree R, Truong XT. | 1986 | Delta-9-THC | Controlled study | Delta-9-THC proved clinically beneficial in two of five patients with intractable spasticity. | ||||||
| Show | Bipolar disorders | The effect of extreme marijuana use on the long-term course of bipolar I illness: a single case study. | El-Mallakh RS, Brown C. | 2007 | Cannabis | Uncontrolled case report | Cannabis decreased the number of depressed days and increased the number of hypomanic days. | ||||||
| Show | The effect of five day dosing with THCV on THC-induced cognitive, psychological and physiological effects in healthy male human volunteers: A placebo-controlled, double-blind, crossover pilot trial. | Englund A, Atakan Z, Kralj A, Tunstall N, Murray R, Morrison P. | 2015 | Delta-9-THC | Controlled study | Inhibition of some of the well-known effects of THC by THCV and potentiation of other effects | |||||||
| Show | Dependency/withdrawal | The effect of high-dose dronabinol (oral THC) maintenance on cannabis self-administration | Schlienz NJ, Lee DC, Stitzer ML, Vandrey R | 2018 | Delta-9-THC | Controlled study | High doses of oral THC reduced intake of inhaled THC | ||||||
| Show | Pain | The Effect of Medicinal Cannabis on Pain and Quality of Life Outcomes in Chronic Pain: A Prospective Open-label Study. | Haroutounian S, Ratz Y, Ginosar Y, Furmanov K, Saifi F, Meidan R, Davidson E. | 0000 | Cannabis | Open study | Cannabis reduced pain and opioid use | ||||||
| Show | Appetite loss/weight loss;Cancer | The effect of nabilone on appetite, nutritional status, and quality of life in lung cancer patients: a randomized, double-blind clinical trial | Turcott JG, Del Rocío Guillen Núñez M, Flores-Estrada D, Oñate-Ocaña LF, Zatarain-Barrón ZL, Barrón F, Arrieta O | 2018 | Nabilone | Controlled study | Nabilone improved appetite in cancer patients in a controlled clinical study | ||||||
| Show | Multiple sclerosis; Spinal cord injury; Spasticity; Pain | The effect of orally and rectally administered delta-9-tetrahydrocannabinol on spasticity: a pilot study with 2 patients. | Brenneisen R, Egli A, Elsohly MA, Henn V, Spiess Y | 1996 | Delta-9-THC | improvement of joint function and ability to walk; in 1 patient additional alleviation of pain | |||||||
| Show | Psychosis/schizophrenia | The effects of cannabidiol (CBD) on cognition and symptoms in outpatients with chronic schizophrenia a randomized placebo controlled trial | Boggs DL et al. | 2018 | Cannabidiol | Controlled study | CBD did not improve cognition in patients with schizophrenia | ||||||
| Show | Dependency/withdrawal | The effects of cannabidiol on impulsivity and memory during abstinence in cigarette dependent smokers. | Hindocha C, Freeman TP, Grabski M, Crudgington H, Davies AC, Stroud JB, Das RK, Lawn W, Morgan CJA, Curran HV. | 2018 | Cannabidiol | Controlled study | |||||||
| Show | Pain | The effects of nabilone on sleep in fibromyalgia: results of a randomized controlled trial. | Ware MA, Fitzcharles MA, Joseph L, Shir Y. | 2010 | Nabilone | Controlled study | Improvement of sleep by nabilone. | ||||||
| Show | HIV/AIDS;Pain | The effects of smoked cannabis in painful peripheral neuropathy and cancer pain refractory to opiods. | Abrams DI, Jay Ch, Petersen K, Shade S, Vizoso H, Reda H, Benowitz N, Rowbotham M. | 2003 | Cannabis | Open study | 10 of the 16 participants experienced a greater than 30% reduction in their pain | ||||||
| Show | Parkinson's disease | The effects of the cannabinoid receptor agonist nabilone on L-DOPA induced dyskinesia in patients with idiopathic Parkinson's disease (PD). | Sieradzan KA, Fox SH, Dick J, Brotchie JM. | 1998 | Nabilone | Controlled study | Activation of cannabinoid receptors can reduce L-DOPA-induced dyskinesia in man without aggravating parkinsonism. | ||||||
| Show | Anxiety | The efficacy and safety of nabilone (a synthetic cannabinoid) in the treatment of anxiety. | Fabre LF, McLendon D. | 1981 | Nabilone | Controlled study | Dramatic improvement in anxiety | ||||||
| Show | Posttraumatic stress disorder | The efficacy of nabilone, a synthetic cannabinoid, in the treatment of PTSD-associated nightmares: A preliminary randomized, double-blind, placebo-controlled cross-over design study. | Jetly R, Heber A, Fraser G, Boisvert D. | 2015 | Nabilone | Controlled study | Nabilone reduced nightmares. | ||||||
| Show | The Grass Might Be Greener: Medical Marijuana Patients Exhibit Altered Brain Activity and Improved Executive Function after 3 Months of Treatment | Gruber SA, Sagar KA, Dahlgren MK, Gonenc A, Smith RT, Lambros AM, Cabrera KB, Lukas SE | 2018 | Cannabis | Open study | The medical use of cannabis improves cognitive performance | |||||||
| Show | Appetite loss/weight loss | The Impact of Δ9-THC on the Psychological Symptoms of Anorexia Nervosa: A Pilot Study | Avraham Y, Latzer Y, Hasid D, Berry EM | 2017 | Delta-9-THC | Open study | THC may improve symptoms of anorexia nervosa | ||||||
| Show | Pain | The Impact of Cannabis Access Laws on Opioid Prescribing | McMichael, Benjamin J. and Van Horn, Ray and Viscusi, W. Kip | 2018 | Cannabis | Survey | Cannabis laws in the USA are associated with reduced opioid prescriptions | ||||||
| Show | Psychosis/schizophrenia | The impact of current cannabis use on general cognitive function in people with psychotic illness | Waterreus A, Badcock JC, Di Prinzio P, Martin-Iverson M, Morgan VA | 2017 | Cannabis | Controlled study | No difference in cognitive abilities between people with psychosis with and without cannabis use | ||||||
| Show | The influence of substance use on the effectiveness of antipsychotic medication: a prospective, pragmatic study. | Alisauskiene R, Løberg EM, Gjestad R, Kroken RA, Jørgensen HA, Johnsen E. | 2019 | Open study | Cannabis had no influence on the efficacy of antipsychotic medication | ||||||||
| Show | Cancer | The medical necessity for medicinal cannabis: prospective, observational study evaluating the treatment in cancer patients on supportive or palliative care. | Bar-Sela G, Vorobeichik M, Drawsheh S, Omer A, Goldberg V, Muller E. | 2013 | Cannabis | Open study | In an open clinical study with cancer patients all symptoms improved significantly. | ||||||
| Show | The medicinal use of cannabis and cannabinoids: an international survey on methods of intake. | Hazekamp A, Grotenhermen F, Abrams D, Russo E, Ware M, Navarrete-Varo R, Brenneisen R, Müller-Vahl K. | 2011 | Cannabis;Delta-9-THC;Nabilone | Survey | Preferred modes of use were smoking of cannabis (62.9 per cent), inhalation of cannabis with a vaporizer (23.6 per cent), oral use of cannabis in baked goods (7.9 per cent), oral use of cannabis as a tea (2.4 per cent), and oral use of dronabinol/Marinol (1.8 per cent). | |||||||
| Show | The medicinal use of cannabis in the UK: results of a nationwide survey. | Ware MA, Adams H, Guy GW. | 2005 | Cannabis | Survey | Cannabis use was reported by 25 % of patients with chronic pain and 22 % of patients with multiple sclerosis | |||||||
| Show | Pain | The MOBILE Study-A Phase IIa Enriched Enrollment Randomized Withdrawal Trial to Assess the Analgesic Efficacy and Safety of ASP8477, a Fatty Acid Amide Hydrolase Inhibitor, in Patients with Peripheral Neuropathic Pain. | Bradford D et al. | 2017 | Other cannabinoids | Controlled study | A FAAH inhibitor did not reduce neuropathic pain | ||||||
| Show | Spasticity;Spinal cord injury;Pain | The perceived effects of marijuana on spinal cord injured males. | Dunn M, Davis R. | 1974 | Cannabis | Survey | Decrease in pain and spasticity. | ||||||
| Show | Spasticity;Multiple sclerosis;Pain;Tremor;Depression | The perceived effects of smoked cannabis on patients with multiple sclerosis. | Consroe P, Musty R, Rein J, Tillery W, Pertwee R | 1997 | Cannabis | Survey | In more than 80% improvement of spasticity, pain, tremor, depression, anxiety, and paresthesia | ||||||
| Show | Pain | The Pharmacokinetics, Efficacy, Safety, and Ease of Use of a Novel Portable Metered-Dose Cannabis Inhaler in Patients With Chronic Neuropathic Pain: A Phase 1a Study | Eisenberg E, Ogintz M, Almog S | 2014 | Cannabis | Open study | A significant reduction in pain intensity was achieved after cannabis inhalation with a vaporizer. | ||||||
| Show | Dependency/withdrawal;Pain | The prescription of medical cannabis by a transitional pain service to wean a patient with complex pain from opioid use following liver transplantation: a case report. | Meng H, Hanlon JG, Katznelson R, Ghanekar A, McGilvray I, Clarke H. | 2015 | Cannabis | Uncontrolled case report | The use of cannabis reduced opioid consumption | ||||||
| Show | Cancer | The Prevalence of Nonprescription Cannabinoid-Based Medicines in British Children's Hospices: Results of a National Survey. | Tatterton MJ, Walker C. | 2019 | Cannabis | Survey | Many families use cannabis oil for their children in British hospices | ||||||
| Show | The relationship between cannabis use and diabetes: Results from the National Epidemiologic Survey on Alcohol and Related Conditions III | Imtiaz S, Rehm J. | 2018 | Cannabis | Survey | Cannabis use is associated with significant reduction in occurrence of diabetes | |||||||
| Show | Dependency/withdrawal | The relationship between motivations for cannabis consumption and problematic use. | Casajuana Kögel C, López-Pelayo H, Oliveras C, Colom J, Gual A, Balcells-Oliveró MM. | 2019 | Cannabis | Open study | The risk for problematic use of cannabis depends on reason for use | ||||||
| Show | The relationship between substance use and posttraumatic stress disorder in a methadone maintenance treatment program. | Villagonzalo KA, Dodd S, Ng F, Mihaly S, Langbein A, Berk M. | 2010 | Cannabis | Survey | Cannabis may be used to self-treat posttraumatic stress disorder (PTSD) | |||||||
| Show | Pain | The relationship of endocannabinoidome lipid mediators with pain and psychological stress in women with fibromyalgia - a case control study | Stensson N, Ghafouri N, Ernberg M, Mannerkorpi K, Kosek E, Gerdle B, Ghafouri B | 2018 | Other cannabinoids | Controlled study | Fibromyalgia is associated with increased blood levels of endocannabinoids | ||||||
| Show | Appetite loss/weight loss;HIV/AIDS | The safety and pharmacokinetics of single-agent and combination therapy with megestrol acetate and dronabinol for the treatment of HIV wasting syndrome. The DATRI 004 Study Group. Division of AIDS Treatment Research Initiative. | Timpone JG, Wright DJ, Li N, Egorin MJ, Enama ME, Mayers J, Galetto G | 1997 | Delta-9-THC | Controlled study | weight loss with THC, weight gain with megestrol acetate | ||||||
| Show | Pain | The subjective psychoactive effects of oral dronabinol studied in a randomized, controlled crossover clinical trial for pain. | Issa MA, Narang S, Jamison RN, Michna E, Edwards RR, Penetar DM, Wasan AD. | 2014 | Cannabis;Delta-9-THC | Controlled study | Oral THC had similar psychoactive effects to smoked marijuana | ||||||
| Show | Pain | The Subjective Psychoactive Effects of Oral Dronabinol Studied in a Randomized, Controlled Crossover Clinical Trial For Pain. | Issa MA, Narang S, Jamison RN, Michna E, Edwards RR, Penetar DM, Wasan AD. | 2013 | Cannabis;Delta-9-THC | Controlled study | In pain patients, oral dronabinol has similar psychoactive effects to smoking cannabis. | ||||||
| Show | Nausea/vomiting;Appetite loss/weight loss;Cancer;Pain;Depression;Anxiety | The synthetic cannabinoid nabilone improves pain and symptom management in cancer patients | Maida V. | 2006 | Nabilone | Open study | Nabilone treatment improved pain, nausea, appetite and several other symptoms | ||||||
| Show | Spasticity;Spinal cord injury | The treatment of spasticity with D9-tetrahydrocannabinol (D9-THC) in patients with spinal cord injury | Hagenbach U, Luz S, Brenneisen R, Mäder M | 2003 | Delta-9-THC | Controlled study | Significant reduction of spasticity | ||||||
| Show | Spasticity;Spinal cord injury | The treatment of spasticity with Delta(9)-tetrahydrocannabinol in persons with spinal cord injury. | Hagenbach U, Luz S, Ghafoor N, Berger JM, Grotenhermen F, Brenneisen R, Mader M. | 2006 | Delta-9-THC | Open study | Significant improvement of spasticity with THC | ||||||
| Show | Epilepsy | The use of cannabidiol for seizure management in patients with brain tumor-related epilepsy | Warren PP, Bebin EM, Nabors LB, Szaflarski JP | 2017 | Cannabidiol | Uncontrolled case report | CBD may be effective in epilepsy due to brain tumours according to a case series | ||||||
| Show | Bipolar disorders | The use of cannabis as a mood stabilizer in bipolar disorder: anecdotal evidence and the need for clinical research. | Grinspoon L, Bakalar JB. | 1998 | Cannabis | Uncontrolled case report | A number of patients find cannabis (marihuana) useful in the treatment of their bipolar disorder | ||||||
| Show | Dependency/withdrawal | Therapeutic use of cannabis by crack addicts in Brazil. | Labigalini E Jr, Rodrigues LR, Da Silveira DX. | 1999 | Cannabis | Open study | Cannabis use helped patients to quit crack use by reducing the craving symptoms | ||||||
| Show | Dependency/withdrawal | Therapeutic use of cannabis by crack addicts in Brazil. | Labigalini E, Jr., Rodrigues LR, Da Silveira DX. | 1999 | Cannabis | Open study | Cannabis reduced craving and helped patients to quit cocaine | ||||||
| Show | Glaucoma | Topical delta 9-tetrahydrocannabinol and aqueous dynamics in glaucoma. | Merritt JC, Perry DD, Russell DN, Jones BF | 1981 | Delta-9-THC | Controlled study | no effect | ||||||
| Show | Pain | Topical Medical Cannabis: A New Treatment for Wound Pain-Three Cases of Pyoderma Gangrenosum | Maida V, Corban J | 2017 | Cannabis | Uncontrolled case report | Topical cannabis reduced wound pain in a small case series | ||||||
| Show | Alzheimer's disease | Treating non-cognitive symptoms of people with dementia | Science Daily | 2018 | Delta-9-THC | Controlled study | Nabilone improves agitation and other behavioural symptoms in patients with Alzheimer’s disease | ||||||
| Show | Multiple sclerosis | Treatment failure of intrathecal baclofen and supra-additive effect of nabiximols in multiple sclerosis-related spasticity: a case report. | Stroet A, Trampe N, Chan A. | 2013 | Cannabis | Uncontrolled case report | A combination of baclofen injections into the cerebrospinal fluid and very low doses of the cannabis extract Sativex was highly effective. | ||||||
| Show | Treatment of a hyperkinetic movement disorder during pregnancy with dronabinol. | Farooq MU, Ducommun E, Goudreau J. | 2009 | Delta-9-THC | Uncontrolled case report | Improvement of her hyperkinetic movement disorder with no signs of tolerance | |||||||
| Show | Diarrhoea;Gastrointestinal disorder;Inflammation | Treatment of Crohn's disease with cannabis: an observational study. | Naftali T, Lev LB, Yablekovitz D, Half E, Konikoff FM. | 2011 | Cannabis | Open study | Of the 30 patients 21 improved significantly | ||||||
| Show | Spasticity | Treatment of human spasticity with delta 9-tetrahydrocannabinol. | Petro DJ, Ellenberger C Jr | 1981 | Delta-9-THC | Controlled study | reduced spasticity with 10 mg THC | ||||||
| Show | Dystonia | Treatment of Meige's syndrome with cannabidiol. | Snider S.R, Consroe P. | 1984 | Cannabidiol | Uncontrolled case report | 50% improvement in spasm severity and frequency | ||||||
| Show | Spasticity;Spinal cord injury | Treatment of spasticity in spinal cord injury with dronabinol, a tetrahydrocannabinol derivative. | Kogel RW, Johnson PB, Chintam R, Robinson CJ, Nemchausky BA. | 1995 | Delta-9-THC | Open study | Spasticity was markedly improved in 2 o 5 patients | ||||||
| Show | Tourette's syndrome | Treatment of Tourette's syndrome with Delta 9-tetrahydrocannabinol (THC): a randomized crossover trial. | Muller-Vahl KR, Schneider U, Koblenz A, Jobges M, Kolbe H, Daldrup T, Emrich HM. | 2002 | Delta-9-THC | Controlled study | Significant improvement of tics and obsessive-compulsive behavior after treatment with THC. | ||||||
| Show | Tourette's syndrome | Treatment of Tourette's syndrome with delta-9-tetrahydrocannabinol. | Muller-Vahl KR, Schneider U, Kolbe H, Emrich HM. | 1999 | Delta-9-THC | Uncontrolled case report | Improvement of tics and obsessive-compulsive behavior | ||||||
| Show | Epilepsy | Treatment with CBD in oily solution of drug-resistant paediatric epilepsies. | Pelliccia A, Grassi G, Romano A, Crocchialo P | 2005 | Cannabidiol | Open study | Improvement of epilepsy without side effects | ||||||
| Show | Depression | Trends of major depressive episode among people with cannabis use: Findings from the National Survey on Drug Use and Health 2006-2015. | Carrà G, Bartoli F, Crocamo C. | 2019 | Cannabis | Survey | Heavy cannabis use is more likely associated with depression | ||||||
| Show | Epilepsy;Rare diseases | Trial of Cannabidiol for Drug-Resistant Seizures in the Dravet Syndrome | Devinsky O, Cross JH, Laux L, Marsh E, Miller I, Nabbout R, Scheffer IE, Thiele EA, Wright S; Cannabidiol in Dravet Syndrome Study Group. | 2017 | Cannabidiol | Controlled study | Cannabidiol effective against epilepsy in Dravet syndrome | ||||||
| Show | Pain;Posttraumatic stress disorder;Sleep disorder | Use of a Synthetic Cannabinoid in a Correctional Population for Posttraumatic Stress Disorder-Related Insomnia and Nightmares, Chronic Pain, Harm Reduction, and Other Indications: A Retrospective Evaluation. | Cameron C, Watson D, Robinson J. | 2014 | Nabilone | Open study | Nabilone caused significant improvements in insomnia, nightmares, chronic pain and other symptoms in patients suffering from posttraumatic stress disorder (PTSD). | ||||||
| Show | Headache/migraine | Use of cannabis among 139 cluster headache sufferers. | Leroux E, Taifas I, Valade D, Donnet A, Chagnon M, Ducros A. | 2013 | Cannabis | Survey | Less than one third of self-reported users mention a relief of their attacks following inhalation. | ||||||
| Show | Dependency/withdrawal | Use of dronabinol for cannabis dependence: two case reports and review. | Levin FR, Kleber HD. | 2008 | Delta-9-THC | Uncontrolled case report | THC reduced withdrawal symptoms in cannabis dependence | ||||||
| Show | Nausea/vomiting | Use of medical marijuana for treatment of severe intractable nausea after laparoscopic Roux-en-Y gastric bypass surgery: case report. | Merriman AR, Oliak DA. | 2008 | Delta-9-THC | Uncontrolled case report | THC relieved nausea refractory to other medications | ||||||
| Show | Use of palmitoylethanolamide in carpal tunnel syndrome: a prospective randomized study | Faig-Martí J, Martínez-Catassús A | 2017 | Other cannabinoids | Controlled study | Palmitoylethanolamide moderately effective in the treatment of carpal tunnel syndrome | |||||||
| Show | Posttraumatic stress disorder | Using cannabis to help you sleep: heightened frequency of medical cannabis use among those with PTSD. | Bonn-Miller MO, Babson KA, Vandrey R. | 2014 | Cannabis | Survey | Patients with high PTSD scores were more likely to use cannabis to improve sleep, and for coping reasons more generally. | ||||||
| Show | Vaporization as a smokeless cannabis delivery system: a pilot study. | Abrams DI, Vizoso HP, Shade SB, Jay C, Kelly ME, Benowitz NL | 2007 | Cannabis | Controlled study;Basic research | Vaporization of cannabis is a safe and effective mode of delivery of THC | |||||||
| Show | Dependency/withdrawal | White matter integrity in adolescents with histories of marijuana use and binge drinking. | Jacobus J, McQueeny T, Bava S, Schweinsburg BC, Frank LR, Yang TT, Tapert SF. | 2009 | Cannabis | Open study | Brain damage was less in alcohol users who used also cannabis than in alcohol only users. | ||||||
| Show | Pain | [(9)-tetrahydrocannabinol and the opioid receptor agonist piritramide do not act synergistically in postoperative pain.] [Article in German] | Seeling W, Kneer L, Buchele B, Gschwend JE, Maier L, Nett C, Simmet T, Steffen P, Schneider M, Rockemann M. | 2006 | Delta-9-THC | Controlled study | Application of THC reduced the need of an opioid to treat postoperative pain but the difference to placebo was not significant | ||||||
| Show | Pain | [Benefits of an add-on treatment with the synthetic cannabinomimetic nabilone on patients with chronic pain - a randomized controlled trial.] [Article in German] | Pinsger M, Schimetta W, Volc D, Hiermann E, Riederer F, Polz W. | 2006 | Nabilone | Controlled study | Nabilone caused a significant reduction in pain and improvement of quality of life. | ||||||
| Show | Appetite loss/weight loss;Cancer;Nausea/vomiting;Pain;Spasticity | [Cannabinoids in children] [Article in German] Cannabinoide bei Kindern. | Gottschling S. | 2011 | Delta-9-THC | Uncontrolled case report | Reduced pain, spasticity and improved appetite and nausea | ||||||
| Show | Nausea/vomiting;Appetite loss/weight loss;Cancer;Cancer chemotherapy | [Dronabinol for supportive therapy in patients with malignant melanoma and liver metastases.] [Article in German] | Zutt M, Hanssle H, Emmert S, Neumann C, Kretschmer L. | 2006 | Delta-9-THC | Open study | A significant increase in appetite and decrease in nausea in most patients. | ||||||
| Show | [Fitness to drive in spite (because) of THC] [Article in German] | Strohbeck-Kühner P, Skopp G, Mattern R. | 2007 | Cannabis | Uncontrolled case report | Significant improvement of driving-related performance | |||||||
| Show | Nausea/vomiting;Cancer;Cancer chemotherapy | [Randomized comparative trial of a new anti-emetic: nabilone, in cancer patients treated with cisplatin][Article in French] | George M, Pejovic MH, Thuaire M, Kramar A, Wolff JP. | 1983 | Nabilone | Controlled study | Nabilone, in comparison with chlorpromazine did not significantly reduce the number of vomiting, but most patients preferred nabilone. | ||||||
| Show | Spasticity;Spinal cord injury | [Respiratory failure due to delta-9-tetrahydrocannabinol in a tetraplegic patient.]. [Article in German] | Neuburger M, Schley M, Schmelz M, Schuepfer G, Konrad C. | 2006 | Delta-9-THC | Uncontrolled case report | Dronabinol reduced spasticity but worsened respiration | ||||||
| Show | Pain | [Tetrahydrocannabinol for treatment of chronic pain] [Article in German] | Elsner F, Radbruch L, Sabatowski R. | 2001 | Delta-9-THC | Uncontrolled case report | Sufficient pain relief in three patients | ||||||
| Show | Pain | [The therapeutic use of delta-9-tetrahydrocannabinol (dronabinol) in refractory neuropathic pain] [Article in French]. | Clermont-Gnamien S, Atlani S, Attal N, Le Mercier F, Guirimand F, Brasseur L. | 2002 | Delta-9-THC | Open study | No signficant effect of THC on pain | ||||||
| Show | [Topical cannabinoid agonists : An effective new possibility for treating chronic pruritus.] [Article in German] | Stander S, Reinhardt HW, Luger TA. | 2006 | Other cannabinoids | Open study | Topical application of a cream with N-palmitoyl ethanolamine had a good antipruritic effect in most patients. | |||||||