Clinical Studies and Case Reports

On this site you will find clinical studies with cannabis or single cannabinoids in different diseases and case reports on the use of cannabis by patients.
You may search for diseases (indications), authors, medication, study design (controlled study, open trial, case report etc.) and other criteria.




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TitleRecent clinical experience with dronabinol.
Author(s)Plasse TF, Gorter RW, Krasnow SH, Lane M, Shepard KV, Wadleigh RG
Journal, Volume, IssuePharmacol Biochem Behav. 1991 Nov;40(3):695-700.
Major outcome(s)Significant weight gain
IndicationAppetite loss/weight loss;HIV/AIDSAbstract
MedicationDelta-9-THC

Dronabinol, delta-9-tetrahydrocannabinol in sesame oil, has been used for several years as an antiemetic for patients receiving cancer chemotherapy. In combination studies with prochlorperazine, enhancement of efficacy, as measured by duration of episodes of nausea and vomiting and by severity of nausea, has been found. The incidence of psychotropic effects from dronabinol appears to be decreased by concomitant administration of prochlorperazine. In open pilot studies, dronabinol caused weight gain in seven of ten patients with symptomatic HIV infection. In both HIV and cancer patients, dronabinol improved appetite at a dose which was well tolerated for chronic administration.

Route(s)Oral
Dose(s)THC 2x2.5 mg for 5 months
Duration (days)
Participants10 patients with AIDS
DesignOpen study
Type of publicationMedical journal
Address of author(s)UNIMED, Inc., Somerville, NJ 08876.
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