On this site you will find clinical studies with cannabis or single
cannabinoids in different diseases and case reports on the use of cannabis by
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|Title||Recent clinical experience with dronabinol.|
|Author(s)||Plasse TF, Gorter RW, Krasnow SH, Lane M, Shepard KV, Wadleigh RG|
|Journal, Volume, Issue||Pharmacol Biochem Behav. 1991 Nov;40(3):695-700.|
|Major outcome(s)||Significant weight gain|
|Indication||Appetite loss/weight loss;HIV/AIDS||Abstract|
Dronabinol, delta-9-tetrahydrocannabinol in sesame oil, has been used for several years as an antiemetic for patients receiving cancer chemotherapy. In combination studies with prochlorperazine, enhancement of efficacy, as measured by duration of episodes of nausea and vomiting and by severity of nausea, has been found. The incidence of psychotropic effects from dronabinol appears to be decreased by concomitant administration of prochlorperazine. In open pilot studies, dronabinol caused weight gain in seven of ten patients with symptomatic HIV infection. In both HIV and cancer patients, dronabinol improved appetite at a dose which was well tolerated for chronic administration.
|Dose(s)||THC 2x2.5 mg for 5 months|
|Participants||10 patients with AIDS|
|Type of publication||Medical journal|
|Address of author(s)||UNIMED, Inc., Somerville, NJ 08876.|