Clinical Studies and Case Reports

On this site you will find clinical studies with cannabis or single cannabinoids in different diseases and case reports on the use of cannabis by patients.
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TitleMedical marijuana laws are associated with increases in substance use treatment admissions by pregnant women.
Author(s)Meinhofer A, Witman A, Murphy S, Bao Y.
Journal, Volume, IssueAddiction. [Epub ahead of print]
Major outcome(s)Legalisation of cannabis for medical use in the US increased cannabis use by pregnant women
IndicationAbstract
MedicationCannabis

BACKGROUND AND AIMS:
Between 2002 and 2014, past month marijuana use among pregnant women in the U.S. increased 62%, nearly twice the growth of the general population. This growth coincides with the proliferation of state medical marijuana laws (MMLs) authorizing physicians to recommend marijuana for approved conditions. We estimated the association between MMLs and substance use treatment utilization among pregnant and nonpregnant women of reproductive age. We also examined whether the association varied across MML provisions, age groups, and treatment referral sources to clarify potential pathways.

DESIGN:
Nationwide administrative data from the 2002 to 2014 Treatment Episodes Data Set Admissions, and a difference-in-differences design that exploited the staggered implementation of MMLs to compare changes in outcomes before and after implementation between MML and non-MML states.

SETTING:
21 MML and 27 non-MML U.S. states.

PARTICIPANTS:
Pregnant and nonpregnant women ages 12 to 49 admitted to publicly funded specialty substance use treatment facilities.

MEASUREMENTS:
The primary outcome variable was the number of treatment admissions per 100,000 women ages 12 to 49, aggregated at the state-year level (N=606). Admissions for marijuana, alcohol, cocaine, and opioids were considered. The primary independent variable was an indicator of MML implementation in a state.

FINDINGS:
Among pregnant women, the rate of marijuana treatment admissions increased by 4.69 [95%CI=1.32, 8.06] in MML states relative to non-MML states. This growth was accompanied by increases in treatment admissions involving alcohol [β=3.19; 95%CI=0.97, 5.41] and cocaine [β=2.56; 95%CI=0.34, 4.79], was specific to adults [β=5.50; 95%CI=1.52, 9.47], and was largest in states granting legal protection for marijuana dispensaries [β=6.37; 95%CI=-0.97, 13.70]. There was no statistically significant association between MMLs and treatment admissions by nonpregnant women.

CONCLUSIONS:
Medical marijuana law implementation in US states has been associated with greater substance use treatment utilization by pregnant adult women, especially in states with legally protected dispensaries.

Route(s)
Dose(s)
Duration (days)
Participants
DesignOpen study
Type of publicationMedical journal
Address of author(s)
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