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|Title||Effect of marihuana on intraocular and blood pressure in glaucoma.|
|Author(s)||Merritt JC, Crawford WJ, Alexander PC, Anduze AL, Gelbart SS|
|Journal, Volume, Issue||Ophthalmology 1980;87(3):222-8|
|Major outcome(s)||Marihuana inhalation decreased intraocular and blood pressure.|
Marihuana inhalation was accompanied by increased heart rate and decreased intraocular and blood pressure in 18 subjects with heterogenous glaucomas. The hypotensive effects appeared in 60 to 90 minutes as the decrease in intraocular pressure (IOP) appeared to follow the decrease in blood pressure. In addition to any local effect, the mechanism of lowered to any local effect, the mechanism of lowered IOP may also involve the decreased pressure perfusing the ciliary body vasculature as a result of the peripheral vasodilatory properties of marihuana. Postural hypotension, tachycardia, palpitations, and alterations in mental status occurred with such frequency as to mitigate against the routine used in the general glaucoma population. Our data indicate that further research should be directed to local means of delivering the ocular hypotensive cannabinoid to the glaucomatous eye.
|Dose(s)||Smoked THC (2%)|
|Participants||18 patients with glaucoma|
|Type of publication||Medical journal|
|Address of author(s)|