Clinical Studies and Case Reports

On this site you will find clinical studies with cannabis or single cannabinoids in different diseases and case reports on the use of cannabis by patients.
You may search for diseases (indications), authors, medication, study design (controlled study, open trial, case report etc.) and other criteria.

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TitleCannabis substitution. An adjunctive therapeutic tool in the treatment of alcoholism.
Author(s)Mikuriya TH
Journal, Volume, IssueMedical Times 1970;98(4):187-91.
Major outcome(s)Marijuana consumption may help to decrease alcolholic intake.

The physical and psychosocial effects of alcoholism are
varied in kind and amount, depending on each individual
case. The resultant behavior is due to the complex interplay
of pharmacologic effect of alcohol with the psychosocial
aspects of the user. Tamarin and Mendelssohn vividly depict
the destructive effects of prolonged alcohol intoxication :
The anxiety-reduction model often utilized to explain
initiation and perpetuation of episodic drinking was
found inadequate to explain motivation for alcohol use
by the alcoholic. Euphoria and elation were manifest
only during the initial phases of intoxication. Prolonged
guilt, and psychic pain. These unpleasant affects, however,
were poorly recalled by the alcoholics following
cessation of drinking.
The degree of inebriation appeared to be more closely
related to patterns of alcohol ingestion than to the total
volume of alcohol consumed. Compulsive and constricted
behavior patterns, which were present during
sobriety, changed markedly during intoxication, with
increased verbalization, varied expression of feelings,
increased interaction, and frequent behavioral regression.
During inebriation, psychic defenses appeared
weakened with significant reduction of repression and
reaction formation.*
Such chronic abrasive difficulties have been noted by a
patient of mine, a forty-nine-year-old lady (Mrs. A.) with a
history of alcoholism dating back from her teens, unsuccessfully
treated by varied group and individual psychological
treatments for many years. When she was referred to me, she
had *been using illicitly obtained crude marijuana intermittently
with a frequency of perhaps every weekend or so. It
was noted that when she smoked marijuana she decreased her
alcoholic intake. I instructed her to substitute cannabis daily
-any time she felt the urge to partake in alcohol.
drinking was characterized by progressive depression,

Duration (days)
Participants1 alcoholic
DesignUncontrolled case report
Type of publicationMedical journal
Address of author(s)California Cannabis Research Medical Group, CA 94708 - 1757 Berkley
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