Clinical Studies and Case Reports

On this site you will find clinical studies with cannabis or single cannabinoids in different diseases and case reports on the use of cannabis by patients.
You may search for diseases (indications), authors, medication, study design (controlled study, open trial, case report etc.) and other criteria.




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TitleDronabinol for the Treatment of Paraneoplastic Night Sweats in Cancer Patients: A Report of Five Cases.
Author(s)Carr C, Vertelney H, Fronk J, Trieu S.
Journal, Volume, IssueJ Palliat Med. [Epub ahead of print]
Major outcome(s)THC may reduce night sweats in cancer patients
IndicationCancerAbstract
MedicationDelta-9-THC

BACKGROUND:
Night sweats significantly impact the quality of life for cancer patients and are often resistant to treatment. Cannabinoids have been shown to modulate cytokine activity and produce hypothermia in animal models, suggesting that they may be a promising candidate for palliation of night sweats in patients with oncologic disease.

OBJECTIVE:
Assess efficacy of the oral cannabinoid, dronabinol, for palliation of night sweats in cancer patients.

DESIGN:
A retrospective record search identified five cancer patients who had tried oral dronabinol for palliation of their night sweats between 2013 and 2016 and subjectively reported on its efficacy.

SETTING/SUBJECTS:
A convenience sample of five patients from the outpatient consultative palliative medicine program at Stanford Medical Center was chosen from a search of past records. Patients were included if they had a cancer diagnosis and complained of night sweats that subjectively interfered with their quality of life. All agreed to try oral dronabinol for palliation of their night sweats.

MEASUREMENTS:
Patients self-reported the effect of oral synthetic dronabinol on their night sweats.

RESULTS:
Treatment of five patients with advanced cancer with synthetic orally administered dronabinol resulted in the successful management of persistent symptomatic paraneoplastic night sweats.

CONCLUSION:
Dronabinol and/or medicinal cannabis are promising therapies for palliation of night sweats in cancer patients.

Route(s)
Dose(s)
Duration (days)
Participants
DesignUncontrolled case report
Type of publicationMedical journal
Address of author(s)
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