Clinical Studies and Case Reports

On this site you will find clinical studies with cannabis or single cannabinoids in different diseases and case reports on the use of cannabis by patients.
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Title
Author(s)Alcohol and Cannabis Use Alter Pulmonary Innate Immunity.
Journal, Volume, IssueAlcohol. [Epub ahead of print]
Major outcome(s)Smoking of cannabis may promote airway inflammation
IndicationAbstract
MedicationCannabis

PURPOSE:
Cannabis use is increasing due to recent legislative changes. In addition, cannabis is often used in conjunction with alcohol. The airway epithelium is the first line of defense against infectious microbes. Toll-like receptors (TLR) recognize airborne microbes and initiate the inflammatory cytokine response. How cannabis use in conjunction with alcohol affects pulmonary innate immunity mediated by TLRs is unknown.

METHODS:
Samples and data from an existing cohort of individuals with alcohol use disorders (AUDs), along with samples from additional participants with cannabis use alone and with AUD were utilized. Subjects were categorized into the following groups: no alcohol use disorder (AUD) or cannabis use (Control) (n=46), AUD only (n=29), Cannabis use only (n=39) and AUD and Cannabis use (n= 29). The participants underwent bronchoscopy with bronchoalveolar lavage (BAL) and airway epithelial brushings. We measured IL-6, IL-8, TNF⍺ and IL-10 levels in BAL fluid, and performed real time PCR for TLR1-9 on the airway epithelial brushings.

RESULTS:
We found significant increases in TLR2 with AUD alone, cannabis use alone and cannabis use with AUD compared to control. TLR5 was increased in cannabis users compared to control, TLR6 was increased in cannabis users and cannabis users with AUD compared to control, TLR7 was increased in cannabis users compared to control, and TLR9 was increased compared to control. In terms of cytokine production, IL-6 was increased in cannabis users compared to control. IL-8 and IL-10 were increased in AUD only.

CONCLUSIONS:
AUD and cannabis use have complex effects on pulmonary innate immunity that promote airway inflammation.

Route(s)Inhalation
Dose(s)
Duration (days)
Participants
DesignOpen study
Type of publicationMedical journal
Address of author(s)
Full text

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