Clinical Studies and Case Reports

On this site you will find clinical studies with cannabis or single cannabinoids in different diseases and case reports on the use of cannabis by patients.
You may search for diseases (indications), authors, medication, study design (controlled study, open trial, case report etc.) and other criteria.




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TitlePure delta-9-tetrahydrocannabinol and its combination with cannabidiol in treatment-resistant Tourette syndrome: A case report.
Author(s)Pichler EM, Kawohl W, Seifritz E, Roser P.
Journal, Volume, IssueInt J Psychiatry Med. [Epub ahead of print]
Major outcome(s)A case report suggests that CBD may be beneficial in Tourette syndrome
IndicationTourette's syndromeAbstract
MedicationDelta-9-THC;Cannabidiol

Objectives Anecdotal reports and preliminary studies suggest a therapeutic potential of cannabis in Tourette syndrome. We report the case of a female patient suffering from treatment-resistant Tourette syndrome. Methods Guideline-directed antipsychotic treatment with risperidone and aripiprazole as well as pure delta-9-tetrahydrocannabinol had no significant effect on Tourette syndrome symptomatology. Results Following administration of a daily dosage of 10 mg delta-9-tetrahydrocannabinol combined with 20 mg cannabidiol (CBD), the patient showed a rapid and highly significant improvement in the Yale Global Tic Severity Scale. Conclusions It can be speculated whether the beneficial effects may rely on the pharmacological properties of cannabidiol.

Route(s)
Dose(s)
Duration (days)
Participants
DesignUncontrolled case report
Type of publicationMedical journal
Address of author(s)
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