Clinical Studies and Case Reports

On this site you will find clinical studies with cannabis or single cannabinoids in different diseases and case reports on the use of cannabis by patients.
You may search for diseases (indications), authors, medication, study design (controlled study, open trial, case report etc.) and other criteria.




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TitleThe Impact of Δ9-THC on the Psychological Symptoms of Anorexia Nervosa: A Pilot Study
Author(s)Avraham Y, Latzer Y, Hasid D, Berry EM
Journal, Volume, IssueIsr J Psychiatry Relat Sci. ;54(3):44-51
Major outcome(s)THC may improve symptoms of anorexia nervosa
IndicationAppetite loss/weight lossAbstract
MedicationDelta-9-THC

BACKGROUND:
Δ9-Tetrahydrocannabinol (Δ9-THC) is the active compound of Cannabis sativa with appetitestimulating properties. This study evaluated the effect of low doses of oral Δ9-THC on self-reported symptoms of patients suffering from chronic anorexia nervosa (AN).

METHODS:
Nine female subjects over 18 years of age participated in the study. Six were diagnosed according to DSM-IV criteria with AN restrictive type and three with active AN binge-purge type. Their mean age was 45.0±3.2 years and their BMI was 16.1±1.6 kg/M2. They completed questionnaires before and after treatment with Δ9-THC (1 mg/day for one week and 2 mg/day for three weeks). The primary outcome was improvement in the way patients perceived their eating behavior.

RESULTS:
Significant improvements were found in selfreported body care, sense of ineffectiveness, asceticism and depression. There were no significant changes in BMI.

CONCLUSIONS:
Δ9-THC may be an effective component in treating the psychological symptoms of AN.

Route(s)
Dose(s)
Duration (days)
Participants
DesignOpen study
Type of publicationMedical journal
Address of author(s)
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