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|Title||Acute effects of smoked marijuana and oral delta9-tetrahydrocannabinol on specific airway conductance in asthmatic subjects.|
|Author(s)||Tashkin DP, Shapiro BJ, Frank IM.|
|Journal, Volume, Issue||American Review for Respiratory Diseases. 1974 Apr;109(4):420-8.|
|Major outcome(s)||Smoked marijuana and oral THC caused significant bronchodilation of at least 2 hours duration.|
The acute effects of smoked 2 per cent natural marijuana (7 mg per kg) and 15 mg of oral Delta-9-tetrahydrocannabinol (THC) on plethysmographically determined airway resistance (Raw) and specific airway conductance (SGaw) were compared with those of placebo in 10 subjects with stable bronchial asthma using a double-blind crossover technique. After smoked marijuana, SGaw increased immediately and remained significantly elevated (33 to 48 per cent above initial control values) for at least 2 hours, whereas SGaw did not change after placebo. The peak bronchodilator effect of 1,250 myg of isoproterenol was more pronounced than that of marijuana, but the effect of marijuana lasted longer. After ingestion of 15 mg of THC, SGaw was elevated significantly at 1 and 2 hours, and Raw was reduced significantly at 1 to 4 hours, whereas no changes were noted after placebo. These findings indicated that in the asthmatic subjects, both smoked marijuana and oral THC caused significant bronchodilation of at least 2 hours duration.
|Participants||10 subjects with stable bronchial asthma|
|Type of publication||Medical journal|
|Address of author(s)|