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|Title||Speechlessness in Gilles de la Tourette Syndrome: Cannabis-Based Medicines Improve Severe Vocal Blocking Tics in Two Patients|
|Author(s)||Jakubovski E, Müller-Vahl K|
|Journal, Volume, Issue||Int J Mol Sci. ;18(8)|
|Major outcome(s)||Speechlessness in Tourette syndrome may be treated with cannabis/THC according to case reports|
We report the cases of two young German male patients with treatment-resistant Tourette syndrome (TS), who suffer from incapacitating stuttering-like speech disfluencies caused by vocal blocking tics and palilalia. Case 1: a 19-year old patient received medical cannabis at a dose of 1 × 0.1 g cannabis daily. Case 2: a 16-year old patient initially received dronabinol at a maximum dose of 22.4-33.6 mg daily. Both treatments provided significant symptom improvement of vocal blocking tics as well as of comorbid conditions and were well tolerated. Thus, cannabis-based medicine appears to be effective in treatment-resistant TS patients with vocal blocking tics.
|Design||Uncontrolled case report|
|Type of publication||Medical journal|
|Address of author(s)|