Clinical Studies and Case Reports

On this site you will find clinical studies with cannabis or single cannabinoids in different diseases and case reports on the use of cannabis by patients.
You may search for diseases (indications), authors, medication, study design (controlled study, open trial, case report etc.) and other criteria.




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TitleSpeechlessness in Gilles de la Tourette Syndrome: Cannabis-Based Medicines Improve Severe Vocal Blocking Tics in Two Patients
Author(s)Jakubovski E, Müller-Vahl K
Journal, Volume, IssueInt J Mol Sci. ;18(8)
Major outcome(s)Speechlessness in Tourette syndrome may be treated with cannabis/THC according to case reports
IndicationTourette's syndromeAbstract
MedicationCannabis;Delta-9-THC

We report the cases of two young German male patients with treatment-resistant Tourette syndrome (TS), who suffer from incapacitating stuttering-like speech disfluencies caused by vocal blocking tics and palilalia. Case 1: a 19-year old patient received medical cannabis at a dose of 1 × 0.1 g cannabis daily. Case 2: a 16-year old patient initially received dronabinol at a maximum dose of 22.4-33.6 mg daily. Both treatments provided significant symptom improvement of vocal blocking tics as well as of comorbid conditions and were well tolerated. Thus, cannabis-based medicine appears to be effective in treatment-resistant TS patients with vocal blocking tics.

Route(s)
Dose(s)
Duration (days)
Participants
DesignUncontrolled case report
Type of publicationMedical journal
Address of author(s)
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