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cannabinoids in different diseases and case reports on the use of cannabis by
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|Title||Antiemetic effect of tetrahydrocannabinol. Compared with placebo and prochlorperazine in chemotherapy-associated nausea and emesis.|
|Author(s)||Orr LE, McKernan JF, Bloome B|
|Journal, Volume, Issue||Annals of Internal Medicine 1980;140(11):1431-1433|
|Major outcome(s)||no nausea and no vomiting (complete response) in 73% (40/55 courses) in THC group|
|Indication||Cancer chemotherapy; Nausea/vomiting||Abstract|
Fifty-five patients harboring a variety of neoplasms and previously found to have severe nausea or emesis from antitumor drugs were given antiemetic prophylaxis in a double-blind, randomized, crossover fashion. Tetrahydrocannabinol (THC), prochlorperazine, and placebo were compared. Nausea was absent in 40 of 55 patients receiving THC, eight of 55 patients receiving prochlorperazine, and five of 55 in the placebo group. The antiemetic effect of THC appeared to be more efficacious for cyclophosphamide, fluorouracil, and doxorubicin hydrochloride, and less so for mechlorethamine hydrochloride and the nitrosureas. Tetrahydrocannabinol appears to offer significant control of nausea in most patients and exceeding by far that provided by prochlorperazine.
|Dose(s)||4 x 7 mg/m2 every 4 hours|
|Duration (days)||several days|
|Participants||55 cancer patients|
|Type of publication|
|Address of author(s)||Medical Oncology Section, Southern California Cancer Center, California Hosp. Medical Center, Los Angeles, California, USA|