Clinical Studies and Case Reports

On this site you will find clinical studies with cannabis or single cannabinoids in different diseases and case reports on the use of cannabis by patients.
You may search for diseases (indications), authors, medication, study design (controlled study, open trial, case report etc.) and other criteria.




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TitleCannabis and cognitive functioning in multiple sclerosis: The role of gender
Author(s)Patel VP, Feinstein A
Journal, Volume, IssueMult Scler J Exp Transl Clin. ;3(2)
Major outcome(s)Cannabis use may have a negative effect on cognition in male patients with multiple sclerosis
IndicationMultiple sclerosisAbstract
MedicationCannabis

BACKGROUND:
Cognitive function in people with multiple sclerosis (PwMS) is associated with gender differences and the use of smoked/ingested cannabis.

OBJECTIVE:
The objective of this report is to explore a possible gender-cannabis interaction associated with cognitive dysfunction in PwMS.

METHODS:
A retrospective analysis was undertaken of cognitive data collected from 140 PwMS. A general linear model was conducted to determine gender and cannabis effects on processing speed (SDMT), verbal (CVLT-II) and visual (BVMT-R) memory, and executive functions (D-KEFS), while controlling for age and years of education.

RESULTS:
Cannabis was smoked at least once a month by 33 (23.6%) participants. Cannabis users were more impaired on the SDMT (p = 0.044). Men, who comprised 30.7% of the entire sample and 42.2% of cannabis users, were more impaired on the CVLT-II (total learning, p = 0.001; delayed recall, p = 0.004). A cannabis-gender interaction was found with the CVLT-II delayed recall (p = 0.049) and BVMT-R total learning (p = 0.014), where male cannabis users performed more poorly than female.

CONCLUSION:
Males with MS may be particularly vulnerable to the cognitive side effects of smoked cannabis use.

Route(s)
Dose(s)
Duration (days)
Participants
DesignOpen study
Type of publicationMedical journal
Address of author(s)
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