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|Title||The Effect of Medicinal Cannabis on Pain and Quality of Life Outcomes in Chronic Pain: A Prospective Open-label Study.|
|Author(s)||Haroutounian S, Ratz Y, Ginosar Y, Furmanov K, Saifi F, Meidan R, Davidson E.|
|Journal, Volume, Issue||Clin J Pain. 2016 Feb 17. [Epub ahead of print]|
|Major outcome(s)||Cannabis reduced pain and opioid use|
OBJECTIVES: The objective this prospective, open-label study was to determine the long-term effect of medicinal cannabis treatment on pain and functional outcomes in subjects with treatment-resistant chronic pain. METHODS: The primary outcome was change in pain symptom score on the S-TOPS (Treatment Outcomes in Pain Survey - Short Form) questionnaire at 6 months follow-up in intent-to-treat (ITT) population. The secondary outcomes included change in S-TOPS physical, social and emotional disability scales, pain severity and pain interference on brief pain inventory (BPI), sleep problems, and change in opioid consumption. RESULTS: 274 subjects were approved for treatment; complete baseline data were available for 206 (ITT), and complete follow-up data for 176 subjects. At follow-up, pain symptom score improved from median 83.3 (95% CI 79.2-87.5) to 75.0 (95% CI 70.8-79.2), P<0.001. Pain severity score (7.50 [95% CI 6.75-7.75] to 6.25 [95% CI 5.75-6.75] and pain interference score (8.14 [95% CI 7.28-8.43] to 6.71 [95% CI 6.14-7.14]) improved (both P<0.001), together with most social and emotional disability scores. Opioid consumption at follow-up decreased by 44% (P<0.001). Serious adverse effects led to treatment discontinuation in two subjects. DISCUSSION: The treatment of chronic pain with medicinal cannabis in this open-label, prospective cohort resulted in improved pain and functional outcomes, and significant reduction in opioid use. The results suggest long-term benefit of cannabis treatment in this group of patients, but the study's non-controlled nature should be considered when extrapolating the results.
|Participants||274 treatment-resistant chronic pain patients|
|Type of publication||Medical journal|
|Address of author(s)||Pain Relief Unit, Hadassah-Hebrew University Medical Center, Jerusalem, Israel †Division of Clinical and Translational Research, Department of Anesthesiology, Washington University School of Medicine, Saint Louis, MO, USA ‡Department of Anesthesia and Cri|