Clinical Studies and Case Reports

On this site you will find clinical studies with cannabis or single cannabinoids in different diseases and case reports on the use of cannabis by patients.
You may search for diseases (indications), authors, medication, study design (controlled study, open trial, case report etc.) and other criteria.




[Back to Overview]  [IACM Homepage]

TitleAn Exploratory Human Laboratory Experiment Evaluating Vaporized Cannabis in the Treatment of Neuropathic Pain From Spinal Cord Injury and Disease.
Author(s)Wilsey B, Marcotte TD, Deutsch R, Zhao H, Prasad H, Phan A.
Journal, Volume, IssueJ Pain. 2016 Sep;17(9):982-1000. doi: 10.1016/j.jpain.2016.05.010. Epub 2016 Jun 7.
Major outcome(s)Inhaled cannabis reduces neuropathic pain in patients with spinal cord injury
IndicationPain;Spinal cord injuryAbstract
MedicationCannabis

Using 8-hour human laboratory experiments, we evaluated the analgesic efficacy of vaporized cannabis in patients with neuropathic pain related to injury or disease of the spinal cord, most of whom were experiencing pain despite traditional treatment. After obtaining baseline data, 42 participants underwent a standardized procedure for inhaling 4 puffs of vaporized cannabis containing either placebo, 2.9%, or 6.7% delta 9-THC on 3 separate occasions. A second dosing occurred 3 hours later; participants chose to inhale 4 to 8 puffs. This flexible dosing was used to attempt to reduce the placebo effect. Using an 11-point numerical pain intensity rating scale as the primary outcome, a mixed effects linear regression model showed a significant analgesic response for vaporized cannabis. When subjective and psychoactive side effects (eg, good drug effect, feeling high, etc) were added as covariates to the model, the reduction in pain intensity remained significant above and beyond any effect of these measures (all P < .0004). Psychoactive and subjective effects were dose-dependent. Measurement of neuropsychological performance proved challenging because of various disabilities in the population studied. Because the 2 active doses did not significantly differ from each other in terms of analgesic potency, the lower dose appears to offer the best risk-benefit ratio in patients with neuropathic pain associated with injury or disease of the spinal cord.PERSPECTIVE: A crossover, randomized, placebo-controlled human laboratory experiment involving administration of vaporized cannabis was performed in patients with neuropathic pain related to spinal cord injury and disease. This study supports consideration of future research that would include longer duration studies over weeks to months to evaluate the efficacy of medicinal cannabis in patients with central neuropathic pain.

Route(s)Inhalation
Dose(s)placebo, 2.9%, or 6.7% THC
Duration (days)1
Participants42 patients, who suffered from neuropathic pain related to i
DesignControlled study
Type of publicationMedical journal
Address of author(s)VA Northern California Health Care System, Sacramento VA Medical Center, Mather, California; Department of Physical Medicine and Rehabilitation, University of California, Davis Medical Center, Lawrence J. Ellison Ambulatory Care Center, Sacramento, Califo
Full texthttps://www.ncbi.nlm.nih.gov/pubmed?term=27286745

[Back to Overview]  [IACM Homepage]


up