Clinical Studies and Case Reports

On this site you will find clinical studies with cannabis or single cannabinoids in different diseases and case reports on the use of cannabis by patients.
You may search for diseases (indications), authors, medication, study design (controlled study, open trial, case report etc.) and other criteria.




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TitleSeizure exacerbation in two patients with focal epilepsy following marijuana cessation.
Author(s)Hegde M, Santos-Sanchez C, Hess CP, Kabir AA, Garcia PA.
Journal, Volume, IssueEpilepsy Behav 2012;25(4):563-6.
Major outcome(s)Patients with epilepsy were able to control their seizures by the use of cannabis.
IndicationEpilepsyAbstract
MedicationCannabis

While animal models of epilepsy suggest that exogenous cannabinoids may have anticonvulsant properties, scant evidence exists for these compounds' efficacy in humans. Here, we report on two patients whose focal epilepsy was nearly controlled through regular outpatient marijuana use. Both stopped marijuana upon admission to our epilepsy monitoring unit (EMU) and developed a dramatic increase in seizure frequency documented by video-EEG telemetry. These seizures occurred in the absence of other provocative procedures, including changes to anticonvulsant medications. We review these cases and discuss mechanisms for the potentially anticonvulsant properties of cannabis, based on a review of the literature.

Route(s)Inhalation
Dose(s)
Duration (days)
ParticipantsTwo patients with epilepsy
DesignUncontrolled case report
Type of publicationMedical journal
Address of author(s)Epilepsy Center, Department of Neurology, University of California, San Francisco, San Francisco, CA 94143-0138, USA. manu.hegde@ucsf.edu
Full textwww.ncbi.nlm.nih.gov/pubmed/23159379

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