On this site you will find clinical studies with cannabis or single
cannabinoids in different diseases and case reports on the use of cannabis by
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|Title||Proof of concept trial of dronabinol in obstructive sleep apnea.|
|Author(s)||Prasad B, Radulovacki MG, Carley DW.|
|Journal, Volume, Issue||Front Psychiatry 2013;4:1.|
|Major outcome(s)||THC significantly improved this condition.|
STUDY OBJECTIVE: Animal data suggest that Δ(9)-TetraHydroCannabinol (Δ(9)THC) stabilizes autonomic output during sleep, reduces spontaneous sleep-disordered breathing, and blocks serotonin-induced exacerbation of sleep apnea. On this basis, we examined the safety, tolerability, and efficacy of dronabinol (Δ(9)THC), an exogenous Cannabinoid type 1 and type 2 (CB1 and CB2) receptor agonist in patients with Obstructive Sleep Apnea (OSA). DESIGN AND SETTING: Proof of concept; single-center dose-escalation study of dronabinol.
|Participants||17 patients suffereding from sleep apnoea|
|Type of publication||Medical journal|
|Address of author(s)||Department of Medicine, University of Illinois at Chicago Chicago, IL, USA.|