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|Title||Dronabinol for the treatment of agitation and aggressive behavior in acutely hospitalized severely demented patients with noncognitive behavioral symptoms.|
|Author(s)||Woodward MR, Harper DG, Stolyar A, Forester BP, Ellison JM.|
|Journal, Volume, Issue||Am J Geriatr Psychiatry 2014;22(4):415-9.|
|Major outcome(s)||A treatment with oral THC was associated with significant decreases in agitation, as well as improvements in sleep duration and appetite.|
OBJECTIVE: Behavioral disturbances occur frequently in demented individuals and greatly increase the burden of their care. The efficacy of pharmacotherapeutic treatment options is modest. This study was conducted to explore the efficacy and safety of dronabinol as an adjunctive treatment for agitation and aggressive behavior in severely demented patients. METHODS: Using a retrospective systematic chart review, we studied 40 inpatients from the McLean Hospital Geriatric Neuropsychiatry Inpatient Unit diagnosed with dementia and treated with dronabinol for behavioral or appetite disturbances. A group of geriatric psychiatrists consulted medical records to rate the patients' behaviors prior to initiation of dronabinol treatment and following up to seven days of treatment, using the Pittsburgh Agitation Scale, Clinical Global Impression, and Global Assessment of Functioning. Data on percentage of food consumed at each meal, sleep duration, and adverse events were also collected from medical records.
|Participants||40 patients diagnosed with dementia|
|Type of publication||Medical journal|
|Address of author(s)||McLean Hospital Geriatric Psychiatry Research Program, Harvard Medical School, Belmont, MA. Electronic address: firstname.lastname@example.org.|