Clinical Studies and Case Reports

On this site you will find clinical studies with cannabis or single cannabinoids in different diseases and case reports on the use of cannabis by patients.
You may search for diseases (indications), authors, medication, study design (controlled study, open trial, case report etc.) and other criteria.




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TitleDronabinol Treatment of Refractory Nausea and Vomiting Related to Peritoneal Carcinomatosis.
Author(s)Hernandez SL, Sheyner I, Stover KT, Stewart JT.
Journal, Volume, IssueAm J Hosp Palliat Care 2015;32(1):5-7.
Major outcome(s)THC may be very effective in the treatment of nausea and vomiting in end-stage cancer.
IndicationCancer;Nausea/vomitingAbstract
MedicationDelta-9-THC

Nausea and vomiting are common and often highly distressing symptoms in advanced cancer and in hospice and palliative medicine practice. Nausea and vomiting generally respond well to correction of the underlying etiology (when possible) and appropriate selection of antiemetic medication, but up to 7% of patients will have refractory symptoms. Dronabinol is extensively studied for chemotherapy-related nausea and vomiting, but there are only a few case reports of its use in nausea and vomiting unrelated to chemotherapy. We report a patient with end-stage ovarian cancer with peritoneal carcinomatosis and refractory nausea and vomiting who responded dramatically to addition of dronabinol. Dronabinol is usually well tolerated and may have several novel mechanisms of antiemetic action; further study of its scope of efficacy is warranted.

Route(s)Oral
Dose(s)
Duration (days)
Participants
DesignOpen study
Type of publicationMedical journal
Address of author(s)University of South Florida College of Medicine, Tampa, FL, USA.
Full textwww.ncbi.nlm.nih.gov/pubmed/24052427

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