Clinical Studies and Case Reports

On this site you will find clinical studies with cannabis or single cannabinoids in different diseases and case reports on the use of cannabis by patients.
You may search for diseases (indications), authors, medication, study design (controlled study, open trial, case report etc.) and other criteria.




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TitleCannabinoids reduce levodopa-induced dyskinesia in Parkinson's disease: a pilot study.
Author(s)Sieradzan KA, Fox SH, Hill M, Dick JP, Crossman AR, Brotchie JM
Journal, Volume, IssueNeurology 2001;57(11):2108-2111
Major outcome(s)significant reduction of levodopa-induced dyskinesia
IndicationParkinson's diseaseAbstract
MedicationNabilone

The lateral segment of the globus pallidus (GPl) is thought to be overactive in levodopa-induced dyskinesia in PD. Stimulation of cannabinoid receptors in the GPl reduces gamma-aminobutyric acid (GABA) reuptake and enhances GABA transmission and may thus alleviate dyskinesia. In a randomized, double-blind, placebo-controlled, crossover trial (n = 7), the authors demonstrate that the cannabinoid receptor agonist nabilone significantly reduces levodopa-induced dyskinesia in PD.

Route(s)Oral
Dose(s)
Duration (days)
Participants7 patients Parkinson's disease
DesignControlled study
Type of publication
Address of author(s)Department of Neurology, Manchester Royal Infirmary, UK
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