Clinical Studies and Case Reports

On this site you will find clinical studies with cannabis or single cannabinoids in different diseases and case reports on the use of cannabis by patients.
You may search for diseases (indications), authors, medication, study design (controlled study, open trial, case report etc.) and other criteria.




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TitleEfficacy of Inhaled Cannabis on Painful Diabetic Neuropathy
Author(s)Wallace MS, Marcotte TD, Umlauf A, Gouaux B, Atkinson JH
Journal, Volume, IssueJ Pain. 2015 Apr 2. [in press]
Major outcome(s)Inhaled cannabis demonstrated a dose dependent reduction in peripheral treatment-refractory neuropathic pain.
IndicationPainAbstract
MedicationCannabis

Little is understood regarding medicinal marijuana dispensary users. We sought to characterize socio-demographics and reasons for medicinal marijuana use among medical cannabis dispensary patients in Rhode Island. Participants (n=200) were recruited from one of two Compassion Centers in Rhode Island and asked to participate in a short survey, which included assessment of pain interference using the Brief Pain Inventory (BPI). The majority of participants were male (73%), Caucasian (80%), college educated (68%), and had health insurance (89%). The most common reason for medicinal marijuana use was determined to be chronic pain management. Participants were more likely to have BPI pain interference scores of > 5 if they were older (OR: 1.36, 95% CI: 1.04-1.78) or reported using cannabis as a substitute for prescription medications (OR: 2.47, 95% CI: 1.23-4.95), and were less likely to have interference scores of >5 if they had higher income levels (OR: 0.53, 95% CI: 0.40-0.70) or reported having ever received treatment for an alcohol use disorder. One-fifth of participants had a history of a drug or alcohol use disorder. Most participants report that medicinal cannabis improves their pain symptomology, and are interested in alternative treatment options to opioid-based treatment regimens.

Route(s)Inhalation
Dose(s)
Duration (days)
Participants16 patients with painful diabetic peripheral neuropathy
DesignControlled study
Type of publicationMedical journal
Address of author(s)Department of Anesthesiology, School of Medicine, University of California, 9500 Gilman Drive, La Jolla, San Diego, CA 92093. mswallace@ucsd.edu.
Full texthttp://www.ncbi.nlm.nih.gov/pubmed/25843054

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