Clinical Studies and Case Reports

On this site you will find clinical studies with cannabis or single cannabinoids in different diseases and case reports on the use of cannabis by patients.
You may search for diseases (indications), authors, medication, study design (controlled study, open trial, case report etc.) and other criteria.




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TitleA phase II study of delta-9-tetrahydrocannabinol for appetite stimulation in cancer-associated anorexia.
Author(s)Nelson K, Walsh D, Deeter P, Sheehan F
Journal, Volume, IssueJournal of Palliative Care 1994;10(1):14-18
Major outcome(s)increase of appetite in 13 patients
IndicationAppetite loss/weight loss;CancerAbstract
MedicationDelta-9-THC

Purpose: To evaluate the appetite-stimulating properties of delta-9- tetrahydrocannabinol (THC) in patients with anorexia due to advanced cancer. Patients and methods: Nineteen patients with various malignancies were entered. All had cancer-associated anorexia and a life expectancy greater than four weeks. Patients were started on THC 2.5 mg p.o. t.i.d. one hour after meals for four weeks. Evaluations for side effects, efficacy, acceptability and satisfaction were conducted at two and four weeks. Results: 18 patients were evaluable. Ten patients completed the entire 28-day study. Four patients experienced grade I toxicity and three withdrew at their request. Thirteen patients reported an improved appetite. Conclusion: THC is an effective appetite stimulant in patients with advanced cancer. It is well tolerated at low doses. Further studies are needed to determine the most appropriate dose and the specific population most likely to respond.

Route(s)Oral
Dose(s)2.5 mg three times daily
Duration (days)28
Participants18 patients with cancer evaluable
DesignOpen study
Type of publication
Address of author(s)Palliative Care Program, Cleveland Clinic Foundation Ohio, USA
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