Clinical Studies and Case Reports

On this site you will find clinical studies with cannabis or single cannabinoids in different diseases and case reports on the use of cannabis by patients.
You may search for diseases (indications), authors, medication, study design (controlled study, open trial, case report etc.) and other criteria.




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TitleTopical delta 9-tetrahydrocannabinol and aqueous dynamics in glaucoma.
Author(s)Merritt JC, Perry DD, Russell DN, Jones BF
Journal, Volume, IssueJournal of Clinical Pharmacololgy 1981;21(8-9 Suppl):467S-471S
Major outcome(s)no effect
IndicationGlaucomaAbstract
MedicationDelta-9-THC

Systemic delta 9-tetrahydrocannabinol (THC), administered either by smoking marihuana or as synthetic THC in soft gelatin capsules, lowers ocular tension in various glaucomas, but at the expense of significant decreases in systolic blood pressure. Topical THC in light mineral oil vehicles, though effective in laboratory animals, was not shown effective in 0.05 and 0.1% topical solutions when administered to six subjects with primary open-angle glaucoma in a randomized, balanced, double-masked protocol. Light mineral oil, which has an affinity for corneal epithelium, is an optimum vehicle for administering drugs whose mechanisms of action are systemic rather than local within the eye. Further glaucoma research should therefore proceed with marihuanas containing insignificant levels of THC (less than 0.4%) and with various local delivery systems of the ocular-active cannabinoid found in Cannabis sativa.

Route(s)
Dose(s)0.05 and 0.1% THC in light mineral oil
Duration (days)
Participants6 patients with glaucoma
DesignControlled study
Type of publication
Address of author(s)
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