Clinical Studies and Case Reports

On this site you will find clinical studies with cannabis or single cannabinoids in different diseases and case reports on the use of cannabis by patients.
You may search for diseases (indications), authors, medication, study design (controlled study, open trial, case report etc.) and other criteria.




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TitleCannabidiol for the treatment of cannabis withdrawal syndrome: a case report.
Author(s)Crippa JA, Hallak JE, Machado-de-Sousa JP, Queiroz RH, Bergamaschi M, Chagas MH, Zuardi AW.
Journal, Volume, IssueJ Clin Pharm Ther. 2013 Apr;38(2):162-4
Major outcome(s)They were no major withdrawal symptoms.
IndicationDependency/withdrawalAbstract
MedicationCannabidiol

What is known and Objective: Cannabis withdrawal in heavy users is commonly followed by increased anxiety, insomnia, loss of appetite, migraine, irritability, restlessness and other physical and psychological signs. Tolerance to cannabis and cannabis withdrawal symptoms are believed to be the result of the desensitization of CB1 receptors by THC. Case summary: This report describes the case of a 19-year-old woman with cannabis withdrawal syndrome treated with cannabidiol (CBD) for 10 days. Daily symptom assessments demonstrated the absence of significant withdrawal, anxiety and dissociative symptoms during the treatment. What is new and Conclusion: CBD can be effective for the treatment of cannabis withdrawal syndrome.

Route(s)Oral
Dose(s)
Duration (days)10
Participantsa heavy cannabis user
DesignUncontrolled case report
Type of publicationMedical journal
Address of author(s)Department of Neuroscience and Behavior, Ribeirão Preto Medical School, University of São Paulo and INCT Translational Medicine (CNPq)-São Paulo, Brazil. jcrippa@fmrp.usp.br
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