Clinical Studies and Case Reports

On this site you will find clinical studies with cannabis or single cannabinoids in different diseases and case reports on the use of cannabis by patients.
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TitleCannabidiol enhances consolidation of explicit fear extinction in humans.
Author(s)Das RK, Kamboj SK, Ramadas M, Yogan K, Gupta V, Redman E, Curran HV, Morgan CJ
Journal, Volume, IssuePsychopharmacology (Berl). 2013 Apr;226(4):781-92
Major outcome(s)Cannabidiol enhances consolidation of fear extinction in humans.
IndicationAnxiety;Posttraumatic stress disorderAbstract
MedicationCannabidiol

RATIONALE: Whilst Cannabidiol (CBD), a non-psychotomimetic cannabinoid, has been shown to enhance extinction learning in rats, its effects on fear memory in humans have not previously been studied. OBJECTIVES: We employed a Pavlovian fear-conditioning paradigm in order to assess the effects of CBD on extinction and consolidation. METHOD: Forty-eight participants were conditioned to a coloured box (CS) with electric shocks (UCS) in one context and were extinguished in a second context. Participants received 32 mg of CBD either following before or after extinction in a double-blind, placebo-controlled design. At recall, 48 h later, participants were exposed to CSs and conditioning contexts before (recall) and after (reinstatement) exposure to the UCS. Skin conductance and shock expectancy measures of conditioned responding were recorded throughout. RESULTS: Successful conditioning, extinction and recall were found in all three treatment groups. CBD given post-extinction enhanced consolidation of extinction learning as assessed by shock expectancy. CBD administered at either time produced trend level reduction in reinstatement of autonomic contextual responding. No acute effects of CBD were found on extinction. CONCLUSIONS: These findings provide the first evidence that CBD can enhance consolidation of extinction learning in humans and suggest that CBD may have potential as an adjunct to extinction-based therapies for anxiety disorders.

Route(s)Oral
Dose(s)32 mg
Duration (days)
Participants48 healthy volunteers
DesignControlled study
Type of publicationMedical journal
Address of author(s)Clinical Psychopharmacology Unit, University College London, Gower Street, London, WC1E 7HB, UK. ravi.k.das@gmail.com
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