Clinical Studies and Case Reports

On this site you will find clinical studies with cannabis or single cannabinoids in different diseases and case reports on the use of cannabis by patients.
You may search for diseases (indications), authors, medication, study design (controlled study, open trial, case report etc.) and other criteria.




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TitleDoes the cannabinoid dronabinol reduce central pain in multiple sclerosis? Randomised double blind placebo controlled crossover trial
Author(s)Svendsen KB, Jensen TS, Bach FW
Journal, Volume, IssueBritish Medical Journal 2004; 329: 253 - 0.
Major outcome(s)Significant reduction of pain by THC
IndicationMultiple sclerosis;PainAbstract
MedicationDelta-9-THC

Objective To evaluate the effect of the oral synthetic
_-9-tetrahydrocannabinol dronabinol on central neuropathic
pain in patients with multiple sclerosis.
Design Randomised double blind placebo controlled crossover
trial.
Setting Outpatient clinic, University Hospital of Aarhus,
Denmark.
Participants 24 patients aged between 23 and 55 years with
multiple sclerosis and central pain.
Intervention Orally administered dronabinol at a maximum
dose of 10 mg daily or corresponding placebo for three weeks
(15-21 days), separated by a three week washout period.
Main outcome measure Median spontaneous pain intensity
(numerical rating scale) in the last week of treatment.
Results Median spontaneous pain intensity was significantly
lower during dronabinol treatment than during placebo
treatment (4.0 (25th to 75th centiles 2.3 to 6.0) v 5.0 (4.0 to 6.4),
P = 0.02), and median pain relief score (numerical rating scale)
was higher (3.0 (0 to 6.7) v 0 (0 to 2.3), P = 0.035). The number
needed to treat for 50% pain relief was 3.5 (95% confidence
interval 1.9 to 24.8). On the SF-36 quality of life scale, the two
items bodily pain and mental health indicated benefits from
active treatment compared with placebo. The number of
patients with adverse events was higher during active treatment,
especially in the first week of treatment. The functional ability of
the multiple sclerosis patients did not change.
Conclusions Dronabinol has a modest but clinically relevant
analgesic effect on central pain in patients with multiple
sclerosis. Adverse events, including dizziness, were more
frequent with dronabinol than with placebo during the first
week of treatment.

Route(s)Oral
Dose(s)10 mg per day
Duration (days)21
Participants24 patients with MS
DesignControlled study
Type of publicationMedical journal
Address of author(s)Danish Pain Research Center and Department of Neurology, Aarhus University Hospital, Noerrebrogade 44, DK-8000 Aarhus C, Denmark. Correspondence to: F W Bach fbach@akh.aaa.dk
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