Clinical Studies and Case Reports

On this site you will find clinical studies with cannabis or single cannabinoids in different diseases and case reports on the use of cannabis by patients.
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TitleA pilot study of the effects of cannabis on appetite hormones in HIV-infected adult men.
Author(s)Riggs PK, Vaida F, Rossi SS, Sorkin LS, Gouaux B, Grant I, Ellis RJ.
Journal, Volume, IssueBrain Res. 2012 Jan 11;1431:46-52.
Major outcome(s)Cannabis modulates the concentration of appetite hormones
IndicationHIV/AIDSAbstract
MedicationCannabis

RATIONALE: The endocannabinoid system is under active investigation as a
pharmacological target for obesity management due to its role in appetite
regulation and metabolism. Exogenous cannabinoids such as tetrahydrocannabinol
(THC) stimulate appetite and food intake. However, there are no controlled
observations directly linking THC to changes of most of the appetite hormones.
OBJECTIVES: We took the opportunity afforded by a placebo-controlled trial of
smoked medicinal cannabis for HIV-associated neuropathic pain to evaluate the
effects of THC on the appetite hormones ghrelin, leptin and PYY, as well as on
insulin.
METHODS: In this double-blind cross-over study, each subject was exposed to both
active cannabis (THC) and placebo.
RESULTS: Compared to placebo, cannabis administration was associated with
significant increases in plasma levels of ghrelin and leptin, and decreases in
PYY, but did not significantly influence insulin levels.
CONCLUSION: These findings are consistent with modulation of appetite hormones
mediated through endogenous cannabinoid receptors, independent of glucose
metabolism.

Route(s)Inhalation
Dose(s)
Duration (days)
Participants7 AIDS patients selected from a clinical study
DesignControlled study
Type of publicationMedical journal
Address of author(s)Center for Medicinal Cannabis Research (CMCR) and HIV Neurobehavioral Research Center (HNRC), University of California, San Diego, USA. roellis@ucsd.edu
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