Clinical Studies and Case Reports

On this site you will find clinical studies with cannabis or single cannabinoids in different diseases and case reports on the use of cannabis by patients.
You may search for diseases (indications), authors, medication, study design (controlled study, open trial, case report etc.) and other criteria.




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TitleEvaluation of intramuscular levonantradol and placebo in acute postoperative pain.
Author(s)Jain AK, Ryan JR, McMahon FG, Smith G.
Journal, Volume, IssueJournal of Clinical Pharmacology 1981;21(8-9 Suppl):320S-326S
Major outcome(s)significant pain relief compared with placebo
IndicationPainAbstract
MedicationOther cannabinoids

Double-blind administration of a single intramuscular dose of 1.5, 2.0, 2.5, or 3.0 mg levonantradol or placebo to 56 patients with moderate to severe postoperative or trauma pain showed significant analgesic effects of each dose of levonantradol as compared to placebo (P less than 0.05). However, no significant dose response was observed. Compared to 2/16 patients on placebo, 23/40 patients (57 per cent) on levonantradol reported one or more side effect. Drowsiness was most frequent. Dry mouth, dizziness, "weird dreams," mild hallucinations, nervousness, apprehension and confusion occurred less frequently. Changes in resting heart rate and blood pressure were minor and general acceptability was good.

Route(s)
Dose(s)1.5-3.0 mg
Duration (days)1
Participants56 patients with postoperative pain
DesignControlled study
Type of publication
Address of author(s)
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