Clinical Studies and Case Reports

On this site you will find clinical studies with cannabis or single cannabinoids in different diseases and case reports on the use of cannabis by patients.
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TitleWhite matter integrity in adolescents with histories of marijuana use and binge drinking.
Author(s)Jacobus J, McQueeny T, Bava S, Schweinsburg BC, Frank LR, Yang TT, Tapert SF.
Journal, Volume, IssueNeurotoxicol Teratol. 2009 Nov-Dec;31(6):349-55.
Major outcome(s)Brain damage was less in alcohol users who used also cannabis than in alcohol only users.
IndicationDependency/withdrawalAbstract
MedicationCannabis

Structural brain abnormalities have been observed in adolescents with alcohol use
disorders but less is known about neuropathological brain characteristics of
teens with sub-diagnostic binge drinking or the common pattern of binge drinking
combined with marijuana use. The goal of this study was to examine white matter
integrity in adolescents with histories of binge drinking and marijuana use.
Diffusion tensor imaging (DTI) was conducted with 42 adolescents (ages 16-19)
classified as controls, binge drinkers, or binge drinkers who are also heavy
marijuana users. Tract based spatial analysis identified shared fiber structure
across individuals and facilitated voxelwise comparisons of fractional anisotropy
(FA) and mean diffusivity (MD) between groups. Significant between group
differences were found in FA in eight white matter regions (ps < or = .016)
between the binge drink-only group and controls, including superior corona
radiata, inferior longitudinal fasciculus, inferior fronto-occipital fasciculus,
and superior longitudinal fasciculus. Interestingly, in 4 of these same regions,
binge drinkers who are also heavy marijuana users had higher FA than binge
drinkers who did not use marijuana (ps<.05). MD did not differ between groups.
Findings are largely consistent with research suggesting less neuropathology in
adolescents without histories of substance use. However, binge drinkers who also
use marijuana did not show as consistent a divergence from non-users as did the
binge drink-only group. Detection of white matter alterations may have
implications in identifying early cognitive dysfunction in substance using
adolescents.

Route(s)Inhalation
Dose(s)
Duration (days)
Participants42 adolescents with heavy alcohol and/or cannabis use
DesignOpen study
Type of publicationMedical journal
Address of author(s)
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