Clinical Studies and Case Reports

On this site you will find clinical studies with cannabis or single cannabinoids in different diseases and case reports on the use of cannabis by patients.
You may search for diseases (indications), authors, medication, study design (controlled study, open trial, case report etc.) and other criteria.




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TitleSurvey on cannabis use in Parkinson's disease: subjective improvement of motor symptoms.
Author(s)Venderova K, Ruzicka E, Vorisek V, Visnovsky P.
Journal, Volume, IssueMovement Disorders 2004;19(9):1102-6.
Major outcome(s)25% of the respondents had taken cannabis and 45.9% of these described some form of benefit.
IndicationParkinson's diseaseAbstract
MedicationCannabis

Summary of the study according to an article of Reuters Health of 13 November 2002 on a presentation of the results at a scientific meeting:

Nearly half of Parkinson's disease patients who have tried cannabis say the drug helped relieve their symptoms, according to a patients' survey. Dr. Evzin Ruzicka, neurologist at Charles University in Prague (Czech Republic), reported the findings at the Movement Disorders Society's Seventh International Congress of Parkinson's Disease and Movement Disorders held on 10-14 November in Miami (USA).
The investigators asked all patients who were treated for Parkinson's disease at a centre in Prague to complete a questionnaire that asked about cannabis use and about several Parkinson's disease symptoms. Of 630 questionnaires sent out 339 (54%) were returned. Among the responders, 25% reported that they had used cannabis. Most had used it orally, either as fresh or dried leaves.
Within this group, 39 patients (46%) reported that their Parkinson's disease symptoms in general were relieved after they started using cannabis. 26 (31%) reported an improvement in tremor while at rest, and 38 (45%) experienced a relief of bradykinesia. Relief of muscle rigidity was reported by 32 (38%), and 12 (14%) said they had an improvement in levodopa-induced dyskinesias. The respondents reported that the improvement in symptoms occurred an average of 1.7 months after they had started using cannabis. Patients who used it for at least three months were more likely to experience symptom relief than those with shorter experience.

Route(s)Inhalation;Oral
Dose(s)
Duration (days)
Participants339 patients with Parkinson disease
DesignSurvey
Type of publicationMedical journal
Address of author(s)Department of Pharmacology and Toxicology, Faculty of Pharmacy, Charles University, Hradec Kralove, Czech Republic.
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