Clinical Studies and Case Reports

On this site you will find clinical studies with cannabis or single cannabinoids in different diseases and case reports on the use of cannabis by patients.
You may search for diseases (indications), authors, medication, study design (controlled study, open trial, case report etc.) and other criteria.




[Back to Overview]  [IACM Homepage]

TitleEffect of dronabinol on central neuropathic pain after spinal cord injury: a pilot study.
Author(s)Rintala DH, Fiess RN, Tan G, Holmes SA, Bruel BM.
Journal, Volume, IssueAm J Phys Med Rehabil. 2010 Oct;89(10):840-8.
Major outcome(s)No significant difference between THC and diphenhydramine.
IndicationPainAbstract
MedicationDelta-9-THC

OBJECTIVE: To test the efficacy and safety of a cannabinoid, dronabinol, compared with an active control, diphenhydramine, in relieving neuropathic pain in persons with spinal cord injury. DESIGN: A randomized, controlled, double-blind, crossover pilot study. RESULTS: Seven adults with spinal cord injury and neuropathic pain below the level of injury participated. Two participants withdrew while receiving dronabinol, their first medication. For the remaining five participants, change in pain on a scale of 0-10 from baseline to the end of the maintenance phase did not differ significantly between the two medications (mean change, dronabinol: 0.20 ± 0.837, range = -1.00 to 1.00; diphenhydramine: -1.80 ± 2.490, range = -6.00 to 0; Wilcoxon Z = 1.63, P = 0.102). Similar results were found when the average of the two ratings during the maintenance phase was used (dronabinol: -0.20 ± 0.671, range = -0.50 to 1.00; diphenhydramine: -1.40 ± 1.245, range = -3.50 to -0.50; Wilcoxon Z = 1.60, P = 0.109). The most common side effects were dry mouth, constipation, fatigue, and drowsiness for both medications. CONCLUSIONS: On average, dronabinol was no more effective than diphenhydramine for relieving chronic neuropathic pain below the level of injury.

Route(s)Oral
Dose(s)
Duration (days)
Participants7 patients with neuropathic pain due to spinal cord injury
DesignControlled study
Type of publicationMedical journal
Address of author(s)Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas, USA.
Full text

[Back to Overview]  [IACM Homepage]


up