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|Title||Efficacy of tetrahydrocannabinol in patients refractory to standard anti-emetic therapy|
|Author(s)||McCabe M, Smith FP, Goldberg D, Macdonald J, Woolley PV, Warren R|
|Journal, Volume, Issue||Investigational New Drugs 1988;6:243-246|
|Major outcome(s)||THC decreased nausea and vomiting in 23 of 36 (64%) patients|
Oral delta-9-tetrahydrocannabinol (THC), 15 mg/m2, was compared to prochlorperazine (PCZ), 10 mg. for the control of cancer chemotherapy-related emesis. Thirty-six patients whose vomiting was refractory to standard antiemetic therapy were entered in this randomized comparative cross-over study. THC decreased nausea and vomiting in 23 of 36 (64%) patients compared to 1 of 36 receiving PCZ. THC efficacy was not dependent on the class of antineoplastic-agent inducing the emetic symptoms, age of patients or type of sensorial change experienced. Using the 15 mg/m2 dose, all patients experienced transient sensorial changes, characterized as a pleasant "high" in 19 or a variable state of dysphoria in 17 cases. This study confirms the usefulness of THC in patients whose chemotherapy-induced nausea and vomiting is refractory to other standard antiemetics. While excellent antiemetic control was achieved at the dosage 15 mg/m2, dysphoria was encountered at this dose level and we recommend that an initial dose of 5 mg/m2 which, if necessary, can be carefully increased to achieve maximum antiemetic benefit.
|Dose(s)||dronabinol 15 mg/m2 1 h before chemotherapy and every 4 h thereafter for 24 h|
|Participants||36 patients whose vomiting was refractory to standard antiem|
|Type of publication|
|Address of author(s)||Division of Medical Oncology, Vincent T. Lombardi Cancer Research Center, Georgetown University, Washington, D.C. 20007|